| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | DIVERSITY IN EDITING |
| Discussion Leader: Robert Reenan (Brown University) |
| 7:40 pm - 8:00 pm | Robert Reenan (Brown University, USA)
"Regulation of the Drosophila Phenome by ADAR" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Henri Grosjean (CNRS, France)
"The Various Strategies of Codon Decoding in Organisms of the 3 Domains of Life" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Jonatha M. Gott (Case Western Reserve University, USA)
"New forms of editing in Physarum mitochondria" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:15 pm | Nicholas Davidson (Washington University, USA)
"RNA targets for apobec-1 and its complementation factor ACF" |
| 9:15 pm - 9:20 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SNO AND OTHER STABLE RNA MODIFICATIONS |
| Discussion Leader: Eric Phizicky (University of Rochester) |
| 9:00 am - 9:20 am | Eric Phizicky (University of Rochester School of Medicine, USA)
"tRNA modification in yeast" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Michael W. Gray (Dalhousie University, Canada)
"Biochemistry of Mitochondrial 5' tRNA Editing" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | YiTao Yu (University of Rochester Medical Center, USA)
"RNA modification and pre-mRNA splicing regulation" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Maurille (Skip) Fournier (University of Massachusetts, USA)
"SnoRNP-mediated modifications in rRNA influence several aspects of ribosome activity" |
| 10:35 am - 10:40 am | Discussion |
| 10:45 am - 11:15 am | Coffee Break |
| 11:15 am | Group Photo |
| 11:30 am - 11:50 am | Michael P. Terns (University of Georgia, USA)
"RNA-guided Pseudouridylation by H/ACA RNPs" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Tom Meier (Albert Einstein College of Medicine, USA)
"Molecular dissection of complex mammalian pseudouridine synthases: H/ACA ribonucleoproteins" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | INNATE IMMUNE RESPONSE AND HOST DEFENSE |
| Discussion Leader: Bryan Cullen (Duke University) |
| 7:30 pm - 7:50 pm | Bryan Cullen (Duke University, USA)
"Intrinsic immunity to retroviruses and retrotransposons mediated by the APOBEC3 protein family" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Reuben Harris (University of Minnesota, USA)
"Mechanisms of retroelement inhibition by APOBEC3 proteins" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Nina Papavasiliou (The Rockefeller University, USA)
"DNA deamination in adaptive and innate immunity" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Charles Samuel (University of California Santa Barbara, USA)
"Expression and Function of ADAR1 in Response to Pathogen Infection in the Mouse Model" |
| 9:05 pm - 9:10 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MACROMOLECULES MACHINES AND FUNCTIONAL INTERACTIONS |
| Discussion Leader: Barbara Sollner-Webb (The Johns Hopkins University) |
| 9:00 am - 9:20 am | Barbara Sollner-Webb (The Johns Hopkins University, USA)
"Insights into the action of the T. brucei RNA editing complex, from analyzing component proteins" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Maureen Hanson (Cornell University, USA)
"Recognition of C targets of editing in chloroplasts" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Harold C. Smith (University of Rochester, USA)
"Cytoplasmic compartmentalization and function of C to U editing factors" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:05 am | Larry Simpson (University of California Los Angeles, USA)
"Uridine insertion/deletion editing in trypanosomes: Functional interactions between L-complex proteins" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Laurie Read (SUNY Buffalo School of Medicine, USA)
"Modulation of trypanosome RNA editing by the RNA binding protein, RBP16" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Juan Alfonzo (Ohio State University, USA)
"Global and local determinants of tRNA editing in trypanosomatids" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Steve Hajduk (Marine Biological Laboratory, USA)
"Alternative Editing of mRNA Generates Protein Diversity in Trypanosomes" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | EDITING AND RNA INTERFERENCE |
| Discussion Leader: Kazuko Nishikura (Wistar Institute) |
| 7:30 pm - 7:50 pm | Kazuko Nishikura (Wistar Institute, USA)
"Regulation of microRNA processing and expression through RNA editing by ADAR deaminases" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Gordon Carmichael (University of Connecticut Health Center, USA)
"The role of vigilins in connecting ADAR editing to heterochromatic gene silencing" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Brenda Bass (University of Utah, USA)
"Modulation of gene expression by Adenosine deaminases that act on RNA" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Erez Levanon (Harvard Medical School, Boston, USA)
"Analysis of A-to-I RNA editing in human and mouse genomic repeats" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Tao Pan (University of Chicago, USA)
"Toward studies of RNA modifications at the genomic scale" |
| 9:10 pm - 9:15 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENZYME-SUBSTRATE RECOGNITION |
| Discussion Leader: Joshua Rosenthal (University of Puerto Rico) |
| 9:00 am - 9:20 am | Joshua Rosenthal (Institute of Neurobiology, University of Puerto Rico, USA )
"SqADAR: a precocious cephalopod editor" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Peter Beal (University of Utah, USA)
"Structure/activity relationships for A to I RNA editing by ADARs" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Marie Öhman (Stockholm University, Sweden)
"A method to find novel sites of selective A to I editing" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:05 am | Warner Greene (University of California San Francisco, USA)
"The Complexities of APOBEC3G Complexes" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Donna Koslowsky (Michigan State University, USA)
"Kinetic and thermodynamic studies of gRNA/mRNA interaction" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Axel Brennicke (ULM Universitaet, Germany)
"Analysis of trans-factors in plant mitochondrial RNA editing" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Miguel Holmgren (NIH/NINDS, Washington DC, USA)
"RNA editing of the internal cavity of Kv channels alters fast inactivation" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 3 |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | STRUCTURE |
| Discussion Leader: Wim Hol (University of Washington) |
| 7:30 pm - 7:50 pm | Wim Hol (Howard Hughes Medical Institute, University of Washington, USA)
"Crystallographic and Biochemical Studies of the Editosome from Trypanosoma brucei" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Frédéric Allain (Institute of Molecular Biology and Biophysics, Switzerland)
"Structure-specific recognition of RNA by ADAR2 dsRBMs" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Juli Feigon (University of California Los Angeles, USA)
"Structural studies of telomerase and H/ACA snoRNAs" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Adrian R. Ferre-D'Amare (Fred Hutchinson Cancer Research Center, USA)
"Pseudouridine synthases: Use of RNA rigidity and flexibility for recognition" |
| 9:05 pm - 9:10 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MEDICAL CONSEQUENCES |
| Discussion Leader: Ron Emeson (Vanderbilt University) |
| 9:00 am - 9:20 am | Ron Emeson (Vanderbilt University, USA)
"Physiological roles of edited serotonin 2C receptor isoforms" |
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Peter Seeburg (Max-Planck Institute of Medical Research, Germany)
"ADAR2, a role in sporadic ALS?" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Shin Kwak (University of Tokyo, Japan)
"ADAR2 underactivity and death of motor neurons in ALS" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:05 am | Youming Lu (University of Central Florida)
"RNA editing of AMPA receptor GluR2 subunit in neuronal degeneration" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Ingo Greger (The Medical Research Council Laboratory of Molecular Biology, UK)
"RNA editing modulates AMPA receptor biogenesis" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Michael Jantsch (University of Vienna, Austria)
"An RNA-sensor for nucleo-cytoplasmic transport of ADAR1" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Nathaniel Landau (The Salk Institute for Biological Studies, USA)
"The role of APOBEC3 cytidine deaminases in suppression of exogenous and endogenous viruses" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 4 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOT TOPICS |
| Discussion Leader: Mark Macbeth (University of Utah, USA) |
| 7:30 pm - 7:45 pm | Yong Liu (Shanghai Institute of Biological Sciences, China)
"Metabolic Regulation of RNA Editing by ADAR2 in Pancreatic Islets and b-Cells" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Angela Gallo (Ospedale Pediatrico 'Bambino Gesù', Rome, Italy)
"RNA editing deregulation in pediatric astrocytomas and GBMs" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Edward Steele (Australian National University, Canberra,AUSTRALIA)
"The antibody somatic hypermutation pattern contains key features of the A-to-I RNA editing signature" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Mark Stapleton (Lawrence Berkeley Labs, USA)
"Re-coding of mRNA transcripts in Drosophila: new targets and functional consequences" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Jason Carnes (Seattle Biomedical Research Institute, USA)
"The Architecture of Three Distinct T. brucei Editosomes |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Joseph E. Wedekind (University of Rochester, USA)
"Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
