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RNA Editing

Gordon Research Conference

Roles of RNA and DNA Editing and Modification in Cellular Function

January 11 - 16, 2009
Chairs and
Vice Chairs and
Grand Galvez
2024 Seawall Boulevard
Galveston, Texas, United States
 Venue and Travel Information

Conference Description

The 2009 Gordon Research Conference on RNA Editing brings together scientists interested on RNA and DNA editing, as well as a large contingent of scientists working on DNA and RNA modification. This conference has been held for over 10 years and is the only regularly scheduled meeting devoted to these topics. The goal of the conference is to foster the exchange of ideas among individuals working on different types of nucleic acid editing and modification who are at the forefront of this exciting, fast-moving and diverse field with the hope of promoting new insights and deeper understanding of editing and modification mechanisms.

Editing is found in all organisms, including bacteria, protozoans, plants, yeast, flies and mammals. Mechanistically, there are many diverse types of editing that alter the sequence of RNA or DNA. In the case of modifications, their variety and extent are quite astonishing, with almost 100 different nucleosides reported in all types of nucleic acids. Both Editing and Modification influence many vital processes including genetic imprinting, splicing, protein synthesis, immunoglobulin class switch recombination, somatic hypermutation, cancer virus replication and control of miRNA. It is now clear that scientists investigating these diverse processes face many of the same theoretical and technical challenges. Thus, there is an ever-increasing need for cross-fertilization between these fields. The GRC on RNA Editing represents a unique opportunity for members of these fields to interact at a single conference that is at the cutting edge of science.

All participants are encouraged to present posters. To promote junior scientists, the organizers will choose among graduate students, postdoctoral fellows, or junior faculty from the submitted poster abstracts to give short talks. As is our tradition, we will strive to provide a gender balanced and an ethnically and geographically diverse group of speakers in a congenial and friendly environment.

Conference Program

SUNDAY
4:00 pm - 8:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEVOLUTION AND DIVERSITY IN EDITING AND MODIFICATION
Discussion Leader: Jonatha Gott (Case Western)
7:40 pm - 8:00 pm Henri Grosjean (IGM, University Paris-Sud)
"Nucleic acids are not just boring four nucleotide-containing long polymers: a guided tour"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:25 pm Janusz Bujnicki (Int. Inst. Mol. and Cell Bio., Poland)
"Evolution of methyltransferases acting on nucleic acids"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jonatha Gott (Case Western)
"Likely roles of template elements required for RNA editing in Physarum mitochondria"
8:50 pm - 8:55 pm Discussion
8:55 pm - 9:15 pm Patricia Chan (UC-Santa Cruz)
"Analysis of Transfer RNA Introns and 5' Leading Sequence in Hyperthermophilic Pyrobaculum"
9:15 pm - 9:20 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEDITING AND MODIFICATION ENZYMES: SUBSTRATE RECOGNITION AND CATALYSIS
Discussion Leader: Ruslan Aphasizhev (UC-Irvine)
9:00 am - 9:20 am Ruslan Aphasizhev (UC-Irvine)
"Creating functional mRNAs in Trypanosome mitochondria: the new players"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Peter Beal (UC-Davis)
"Nucleoside analogs and in vitro evolution to probe ADAR structure/activity relationships"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Mark Helm (IPMB, Heidelberg)
"Single molecule studies of the structural impact of modified nucleotides in tRNA"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break / Group Photo
10:45 am - 10:55 am Pål Falnes (U of Oslo)
"Oxidative demethylation of RNA by AlkB proteins"
10:55 am - 11:00 am Discussion
11:00 am - 11:20 am Hiroshi Nishimasu (University of Tokyo)
"1.0-A resolution structure of a new RNA modification enzyme"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Jorge Cruz-Reyes (Texas A&M)
"DHAC, a Novel DExH helicase-Associated Complex Interacts with Editosomes in Trypanosoma brucei"
11:45 am - 11:50 am Discussion
11:50 am - 12:10 pm Svend Petersen-Mahrt (London Research Institute)
"DNA Deaminases and DNA Repair: A Beneficial Interplay!?"
12:10 pm - 12:15 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmEDITING AND IMMUNITY
Discussion Leader: Nina Papavasilou (Rockefeller)
7:30 pm - 7:50 pm Nina Papavasilou (Rockefeller)
"Apobec1: roles beyond ApoB editing"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Uttiya Basu (HHMI, Harvard)
"Regulation of Activation Induced Cytidine Deaminase DNA Deamination Activity in B Cells by Serine-38 Phosphorylation"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Ruben Harris (U. of Minnesota)
"Functional and structural studies of the HIV-1 restriction factor APOBEC3G"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Michael Neuberger (MRC, Cambridge)
"Antibody diversification by DNA deamination"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Zachary L. Demorest (U of Minnesota)
"A phospho-switch influences the nucleo-cytoplasmic distribution of AID"
9:20 pm - 9:25 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amIMPACT OF OF EDITING AND MODIFICATION IN RNA INTERFERENCE
Discussion Leader: Kazuko Nishikura (Wistar Inst.)
9:00 am - 9:20 am Kazuko Nishikura (Wistar Inst.)
"Stay energetic and lean by RNA editing"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Masayuki Sakurai (U of Tokyo)
"Large scale identification of A-to-I editing sites in the human brain transcriptome by the ICE method; implication for modulatory effect of A-to-I editing on translational repression mediated by miRNAs"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Gordon Carmichael (U. Connecticut)
"ADAR editing and dsRNA response pathways in human embryonic stem cells"
10:10 am - 10:15 am Discussion
10:15 am - 10:35 am Michael Jantsch (U of Vienna)
"Impact of RNA-editing on non coding RNA sequences"
10:35 am - 10:40 am Discussion
10:40 am Coffee Break
9:00 am - 11:00 amALTERING GENE EXPRESSION: A MODIFIED VIEW
Discussion Leader: Ralph Bock (Max Planck, Postdam-Golm)
11:00 am - 11:20 am Anders Byström (U. of Umeå)
"Wobble uridine modifications in eukaryotes-from yeast to humans"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Ralph Bock (Max Planck, Postdam-Golm)
"Editing deaminases in plants"
11:45 am - 11:50 am Discussion
11:50 am - 12:10 pm Dieter Soll (Yale U.)
"tRNA Editing"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Sebastian Leidel (ETH-Zurich)
"The ubiquitin-related modifier Urm1 acts as a sulfur-carrier in thiolation of eukaryotic tRNA"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmCELLULAR TRAFFICKING AND COMPLEX FORMATION AMONG EDITING ENZYMES
Discussion Leader: Mary O'Connell (MRC, Edinburgh)
7:30 pm - 7:50 pm Larry Simpson (UCLA)
"Search for the elusive editosome"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Julius Lukes (Inst. Parasitology, Czech Rep.)
"A novel protein complex involved in RNA editing in Trypanosoma brucei"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Harold Smith (U. of Rochester)
"Interactions of the host defense factor APOBEC3G in the Cytoplasm"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Mary O'Connell (MRC, Edinburgh)
"Elucidating the cellular pathway underlining neurodegeneration and retinal degeneration in Drosophila that is null for Adar"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Angela Gallo (IRCSS, Rome)
"ADAR2 editing activity modulates cell proliferation and cell migration"
9:20 pm - 9:25 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBIOLOGICAL ROLES OF EDITING AND MODIFICATION
Discussion Leader: Yi-Tao Yu (U. of Rochester)
9:00 am - 9:20 am R. Michael Mulligan (UC-Irvine)
"What can bioinformatics tell us about editing site recognition?"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Robert Reenan (Brown U.)
"ADAR-mediated Fine-Tuning of Behavior"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Yi-Tao Yu (U. of Rochester)
"spliceosomal snRNA modifications and their function in pre-mRNA splicing"
10:10 am - 10:15 am Discussion
10:15 am - 10:35 am Skip Fournier (U. of Massachusetts)
"When rRNA-modifying snoRNPs get sick, ribosomes get sick too"
10:35 am - 10:40 am Discussion
10:40 am Coffee Break
11:00 am - 11:20 am Maureen Hanson (Cornell)
"Stay energetic and fat with RNA editing"
11:20 am - 11:25 am Discussion
11:25 am - 11:45 am Steve Hajduk (U. of Georgia)
"Functional Diversity of Mitochondrial Proteins Generated by Alternative RNA Editing"
11:45 am - 11:50 am Discussion
11:50 am - 12:10 pm Stewart Shuman (Sloan-Kettering)
"Mechanisms of tRNA processing and repair"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jane Jackman (Ohio State U.)
"Mechanism and function of tRNAHis guanylyltransferase (Thg1): insights into 3'-5' nucleotide addition activity from all three domains of life"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmSTRUCTURE AND FUNCTION IN EDITING AND MODIFICATION
Discussion Leader: Fred Allain (ETH-Zurich)
7:30 pm - 7:50 pm Fred Allain (ETH, Zurich)
"Substrate recognition by ADAR2 double-stranded RNA binding domains"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Hong Li (Florida State U.)
"Long Distance Placement of rRNA Substrate by H/ACA Ribonucleoprotein Assemblies"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Joe Wedekind (U. of Rochester)
"A Structural and Functional Characterization of APOBEC3G in Multiple oligomeric States"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Xiaodong Cheng (Emory U.)
"Mammalian DNA methylation: A structural perspective"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Keqiong Ye (Beijing)
"Mechanism of substrate RNA recruitment and release in H/ACA RNA guided pseudouridine synthase"
9:20 pm - 9:25 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCELLULAR AND BIOMEDICAL CONSEQUENCES OF EDITING AND MODIFICATION
Discussion Leader: Michael Jantsch (U. of Vienna)
9:00 am - 9:20 am Brenda Bass (HHMI, U. of Utah)
"Functions of 3' UTRs targeted by ADARs"
9:20 am - 9:25 am Discussion
9:25 am - 9:45 am Jason Carnes (Seattle Biom. Res. Inst.)
"Functional Structure of T. brucei Editosomes"
9:45 am - 9:50 am Discussion
9:50 am - 10:10 am Ron Emeson (Vanderbilt U.)
"RNA editing and human genetic disorders"
10:10 am - 10:15 am Discussion
10:15 am - 10:35 am Simon Wain-Hobson (Pasteur Inst.)
"ADARs and APOBECs: powerful mutators lurking in the genome"
10:35 am - 10:40 am Discussion
10:40 am Coffee Break
11:05 am - 11:25 am Manuel Santos (U. Aveiro, Portugal)
"Global proteome editing by a genetic code alteration in the human pathogen Candida albicans"
11:25 am - 11:30 am Discussion
11:30 am - 11:50 am Tom Meier (Albert Einstein)
"Assembly of mammalian pseudouridylase ribonucleoprotein complexes"
11:50 am - 11:55 am Discussion
11:55 am - 12:15 pm Eric Phizicky (U. of Rochester)
"Degradation of hypomodified mature tRNA species in Saccharomyces cerevisiae"
12:15 pm - 12:20 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session II
6:00 pmDinner
7:30 pm - 9:30 pmIDENTIFICATION AND ENGINEERING OF NEW ENZYMES AND SUBSTRATES
Discussion Leader: Valerie De Crecy (U. of Florida)
7:30 pm - 7:50 pm Eli Eisenberg (Tel Aviv University)
"Widespread cleavage of A-to-I hyper-editing substrates"
7:50 pm - 7:55 pm Discussion
7:55 pm - 8:15 pm Pat Limbach (U. of Cincinnati)
"RNA Modification: Static or Dynamic Events?"
8:15 pm - 8:20 pm Discussion
8:20 pm - 8:40 pm Stefan Maas (Lehigh U.)
"The RNA Editing Dataflow System: Towards the systematic prediction of A-to-I RNA editing recoding sites in the human transcriptome"
8:40 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Valerie DeCrecy (U. of Florida)
"tRNA modification in Archaea"
9:05 pm - 9:10 pm Discussion
9:10 pm - 9:20 pm Erez Levanon (Harvard U.)
"Detection Of A-to-I RNA Editing Sites With Next Generation Sequencing Technology"
9:20 pm - 9:25 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

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