SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Origins and Diversity of Editing and Modification |
| Discussion Leader: Juan Alfonzo (Ohio State University) |
7:40 pm - 8:00 pm | Henri Grosjean (CNRS - CGM)
"Emergence and evolution of the genetic code: co-evolution with RNA modification enzymes"
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8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Juan Alfonzo (Ohio State University)
"Unusual editing required for tRNA processing: expanding editing diversity in T. brucei"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Yi-Tao Yu (University of Rochester Medical Center)
"Expanding the genetic code by targeted pseudouridylation"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Valerie De Crecy-Lagard (University of Florida)
"Biosynthesis and function of the universal tRNA modification threonylcarbamoyladenosine"
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9:15 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Identification and engineering of new enzymes/substrates |
| Discussion Leader: Jane Jackman (Ohio State University) |
9:00 am - 9:20 am | Gordon Carmichael (University of Connecticut Health Center)
"Long noncoding RNAs with snoRNA ends"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Stewart Shuman (Sloan-Kettering Institute)
"New ways of making ends meet: RNA splicing via 3' end-activation"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Jane Jackman (Ohio State University)
"tRNA modification enzymes: new activities lead to alternative biological functions"
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10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Gideon Rechavi (Tel Aviv University)
"Deciphering the transcriptome-wide topology and function of N6-methyladonisne"
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11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Erez Levanon (Bar-Ilan University)
"Editing of retroelements"
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11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Jin Billy Li (Stanford University)
"Systematic identification and profiling of RNA editing" |
11:55 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Editing and Modification in the context of disease |
| Discussion Leader: Josh Rosenthal (University of Puerto Rico) |
7:30 pm - 8:00 pm | Keynote Address: Fred Alt (Harvard Medical School)
"Activation Induced Cytidine Deaminase Functions in IgH Class switching, Somatic Mutation, and Chromosomal Translocations"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Ron Emeson (Vanderbilt University)
"Physiologic consequences of altered Kv1.1 editing" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Thomas Meier (Albert Einstein College of Medicine)
"The complex assembly of H/ACA-type RNA modifying machines under attack by inherited disease and cancer causing mutations"
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8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Josh Rosenthal (University of Puerto Rico)
"Correction of mutations underlying Cystic Fibrosis by site-directed RNA editing"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Roles for Editing and Modification in Immunity and host defense |
| Discussion Leader: Reuben Harris (University of Minnesota) |
9:00 am - 9:20 am | Harold Smith (University of Rochester Medical Center)
"RNA:A3G Complexes Versus DNA:A3G Complexes: Insight Into RNA Inhibition of A3G Deaminase Activity"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Yasumasa Iwatani (National Hospital Organization Nagoya Medical Center)
"Structure-based analysis of APOBEC3 on anti-HIV function"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Reuben Harris (University of Minnesota)
"DNA deamination in cancer" or "Mechanism of HIV restriction by human APOBEC3 proteins"
|
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Mark Helm (Johannes Gutenberg-Universität Mainz)
"The impact of nucleotide modification on recognition of RNA by the innate immune system"
|
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Kazuko Nishikura (The Wistar Institute)
"Interaction of RNA editing and RNA interference mechanism"
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11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Yannick Crow (Univ. of Manchester)
"ADAR1 mutations in the context of the human type I interferonopathy Aicardi-Goutieres syndrome" |
11:55 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Editing and modification as drivers of evolution and adaptation |
| Discussion Leader: Michael Jantsch (University of Vienna, The Max F. Perutz Laboratories) |
7:30 pm - 7:50 pm | Mary O'Connell (University of Edinburgh, MRC Human Genetics Unit)
"Evolutionary conservation of ADAR function"
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7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Eli Eisenberg (Tel Aviv University)
"An edited miRNA controls the circadian rhythm in zebrafish"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Bob Braun (The Jackson Laboratory)
"RNA Editing as a Quantitative Trait: Mapping Determinants in the Diversity Outcross Mouse Population"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Michael Jantsch (University of Vienna, The Max F. Perutz Laboratories)
"Changes in the transcriptome induced by ADARs"
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9:05 pm - 9:10 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation and Biological Consequences of Editing and Modification |
| Discussion Leader: Charles Samuel (University of California, Santa Barbara) |
9:00 am - 9:20 am | Marie Ohman (Stockholm University)
"Regulation of A-to-I editing by a cis-acting inducer" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Larry Simpson (UCLA)
"Co-Localization of RNA editing and Translation in the Mitochondrion of Leishmania tarentolae"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Charles Samuel (University of California, Santa Barbara)
"Functions of ADAR1 in the Host Response to Viral Infection"
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10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Peter Dedon (Massachusetts Institute of Technology)
"Dynamic Reprogramming of tRNA Modifications Controls Stress Response in Procaryotes and Eukaryotes by Codon-biased Translation of Proteins"
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11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Nick Davidson (Washington University)
"A gut check for Apobec-1 mediated C to U RNA editing" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Cintia Hongay (Clarkson University)
"The role of IME4 in metazoan development" |
11:55 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Target Site Recognition and Catalysis by Editing and Modification Enzymes |
| Discussion Leader: Brenda Bass (University of Utah) |
7:30 pm - 7:50 pm | Hong Li (Florida State University)
"Structures of RNA cleavage enzymes in CRISPR-mediated prokaryotic immunity"
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7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Peter Beal (Univ. of California - Davis)
"Probing the human ADAR1 reaction with chemically modified substrates"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Juli Feigon (UCLA)
"Structural studies of RNA-protein complexes involved in RNA processing and telomerase assembly" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Brenda Bass (University of Utah)
"How does human ADAR2 choose its adenosine targets?"
|
9:05 pm - 9:10 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Macromolecular Machines and Functional Interactions |
| Discussion Leader: Ruslan Aphasizhev (University of California - Irvine) |
9:00 am - 9:20 am | Ken Stuart (Univ. of Washington)
"Multiple complexes collaborate in the processing and editing of mitochondrial mRNAs"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Maureen Hanson (Cornell University)
"Components of the Plant Editosome"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Laurie Read (SUNY - Buffalo)
"Structure and function of the trypanosome RNA editing accessory complex, MRB1"
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10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Ruslan Aphasizhev (University of California - Irvine)
"Architecture of the U-insertion/deletion RNA editing holoenzyme"
|
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Ya-Ming Hou (Thomas Jefferson University)
"Guanosine recognition by dissimilar tRNA methyltransferases" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Janusz M. Bujnicki (Adam Mickiewicz University)
"3D structure modeling of a complete set of tRNAs from Escherichia coli and their interactions with aminoacyl-tRNA synthetases" |
11:55 am - 12:00 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Quality control of editing and modification |
| Discussion Leader: Jonatha Gott (Case Western Reserve University) |
7:30 pm - 7:50 pm | Eric Phizicky (University of Rochester Medical Center)
"Rapid tRNA decay: multiple ports of entry" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Chuan He (University of Chicago)
"Reversible RNA methylation: the discovery of RNA demethylases" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Jonatha Gott (Case Western Reserve University)
"New methodologies for studying RNA editing mechanisms in Physarum polycelphalum" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Heather Hundley (Indiana University)
"Catalytically inactive ADARs alter in vivo editing levels via interaction with dsRNA" |
9:05 pm - 9:10 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |