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RNA Editing (GRS)

Gordon Research Seminar

RNA and DNA Editing and Modification: Mechanism, Function and Tools for Precision Medicine

March 23 - 24, 2019

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Gordon Research Seminar on RNA Editing is a unique forum for graduate students, post-docs and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is the biology of RNA and DNA editing and modification with a keynote talk from Dr. Eric Phizicky (University of Rochester Medical Center). The GRS will have two science sessions titled "Function and Mechanism of Nucleic Acids Modifications" and "From Mechanism to Cutting Edge Nucleic Acids Technologies". There will be talks selected from abstracts and two poster sessions. Sessions will be chaired by selected students/postdocs. These sessions aim to connect fundamental mechanisms with the emerging therapeutic applications of the editing technologies. In addition, the GRS will conclude with a panel discussion titled "Diverse Career Pathways for PhDs" aimed at providing a platform for students and post-docs to discuss career development with professionals working in diverse careers.

Related Meeting

This GRS will be held in conjunction with the "RNA Editing" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:30 pm - 4:30 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm	Keynote Session: Conservation and Evolution in the Biology of tRNA Modifications Discussion Leaders: and
3:15 pm - 3:45 pm	"Conservation and Evolution in the Biology of tRNA Modifications"
3:45 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Function and Mechanism of Nucleic Acids Modifications Discussion Leaders: and
5:30 pm - 5:40 pm	"The RNA Degradosome Promotes tRNA Qualilty Control Through Clearance of Hypomodified tRNA"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Genetic Mapping of A-to-I RNA Editing in Human Tissues Links Population Variation and Autoimmune Disease"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"RNA Editing Landscape Demonstrates Reduced Editing in Acute Myeloid Leukemia"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:25 pm	"The RNA Editor, ADAR2, Is Required for Leukocyte Trafficking to Inflamed Tissues"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Loss of ADAR1 Induces Severe Apoptosis by Preventing the Expression of T Cell Receptors During Early Stage of T Cell Development in Mice"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Epitranscriptome: A New Modification in mRNA to Add to the List"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Discovery of Novel Bacterial Queuine Salvage Enzymes and Pathways in Human Pathogens"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Biochemical Characterization of the Human Cytidine Deaminase APOBEC1"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	From Mechanism to Cutting Edge Nucleic Acids Technologies Discussion Leaders: and
9:00 am - 9:10 am	"RNA Editing Within the Trypanosome Mitochondria"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Re-Evaluating the Detection of Dynamic Changes in m6A in mRNA Through Immunoprecipitation-Based Sequencing"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Harnessing Endogenous ADARs for Transcript Repair"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Analyzing Structure and Function of Human ADAR1 Catalytic Domain Through Cysteine Library Screening"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Targeted Editing of Mecp2 RNA in a Mouse Model of Rett Syndrome"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Fluorescent Labeling of mRNA Using Self-Alkylating Ribozymes"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Chemistry to Discover and Decode RNA Acetylation"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Expanding the Scope of Base Editing: Programmable RNA Modification"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Diverse Career Pathways for PhDs Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Diverse Career Pathways for PhDs
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

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Conference History RNA Editing

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