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RNA Editing (GRS)

Gordon Research Seminar

Diverse Roles of Nucleic Acid Modifications: Biological and Technological Advances in Health and Disease

March 18 - 19, 2023

Chairs Dhwani N. Rupani and Agya Karki

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The RNA Editing GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The focus of the 2023 GRS is epitranscriptomics, RNA and DNA editing and modifications. These modifications are highly abundant and naturally occurring in nearly all organisms. The GRS on RNA editing brings together graduate student and post-docs to discuss fundamental mechanisms of these modifications and their aberrations in health and disease. The GRS will have two poster sessions and oral talks will be selected from submitted abstracts. The synergistic arrangement of the GRS and GRC will provide multiple opportunities for trainees to build professional networks and foster scientific collaborations.

Related Meeting

This GRS will be held in conjunction with the "RNA Editing" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Learning Resilience Through Research Discussion Leader: Gjendine Voss (Marine Biological Laboratory, United States)
3:45 pm - 4:25 pm	Jennifer Heemstra (Washington University in St. Louis, United States) "Biomolecules Do Amazing Things But Experiments Still Fail - Learning Resilience Through Research"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Functions and Mechanisms of Nucleic Acid Modifications Discussion Leaders: Jacki Heraud-Farlow (St Vincent's Institute, Australia) and Qin Li (Stanford University, United States)
7:30 pm - 7:40 pm	Wei Liang Gan (CSI/NUS, Singapore) "A Balancing Act of the RNA Editing Enzyme ADAR1 in the Liver: Immune Sensing and Suppression"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Carlos Vasquez (University of California, San Diego, United States) "Linking Reductions in MUTYH DNA Repair to Hereditary Colorectal Cancer"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Franziska Stegemann (University of Rochester, School of Medicine, United States) "S. pombe pus1 Mutants, Lacking Pseudouridine at Multiple Sites in tRNAs and mRNAs, Are Temperature Sensitive Due to Decay of a Single tRNA"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Isobel Bowles (Ohio State University, United States) "Identification of a tRNA-Specific Function for the tRNA Methyltransferase Trm10 in Saccharomyces Cerevisiae"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Boyoon Yang (Indiana University Bloomington, United States) "Uncovering Substrate Recognition of A-to-I RNA Editing Enzymes in vivo"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Winston Cuddleston (Icahn School of Medicine at Mount Sinai, United States) "Resolving the Genetic Risk of Neurological Diseases by Decoding Cis-Regulation of RNA Editing"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Beatrice Casati (German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Germany) "Tumor Warm-Up: RNA Editing for Immunotherapy"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Applications and Technological Advances of Nucleic Acid Modifications Discussion Leader: Herra Mendoza (UC Davis, United States)
9:00 am - 9:10 am	Farley Kwok van der Giezen (The University of Western Australia, Australia) "A Modular Toolkit for Rapid Assembly of Synthetic PPR RNA Binding Proteins"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	Philipp Reautschnig (University of Tuebingen, Germany) "An Engineering Tweak Applied To Circular CLUSTER Guide RNAs Allows to Further Enhance Site-Directed RNA Editing Precision in Vivo"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	Rohini Datta (Stanford University, United States) "Therapeutic A-to-I RNA Editing In Parkinson’s Disease"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	Casey Jacobsen (University of California, Davis, United States) "En Masse Examination of RNA Guides (EMERGe) for ADARs"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Hannah Brinkman (UC Davis, United States) "Nucleoside Analogs in ADAR Guide Strands Targeting 5’-UA Sites"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Brodie Ranzau (UCSD, United States) "Development of an Optimized GFP Reporter Assay to Study the DNA Editing Ability of TadA"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	Verena Volf (Harvard University, United States) "Cryptography in DNA of Living Cells"
10:40 am - 10:45 am	Discussion
10:45 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Diverse Career Pathways for PhDs Discussion Leader: Joseph Smith (State University of New York at Buffalo, United States)
1:30 pm - 2:30 pm	Panel Discussion Diverse Career Pathways for PhDs Jacki Heraud-Farlow (St Vincent's Institute, Australia) Holly Rees (Beam Therapeutics, United States) Hannah Dotson (Addgene, United States) Jennifer Heemstra (Washington University in St. Louis, United States)
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number R13HG011566. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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RNA Editing

March 16 - 21, 2025

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