Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | RNA Computation and
Modeling |
| Discussion Leader: Bruce Shapiro (National Cancer Institute, NIH, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 7:55 pm | Introduction by Discussion Leader |
7:55 pm - 8:20 pm | Bruce Shapiro (National Cancer Institute, NIH, USA) "Computational
Design and Experimental Verification of RNA Therapeutic Switches" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Janusz Bujnicki (International Institute of Molecular and Cell Biology, Poland) "RNA 3D Structure Modeling and Structure-Based Sequence Design" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Shi-Jie Chen (University of Missouri, USA) "Predicting RNA Kissing Complex Formation and Therapeutic Applications" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Monday |
8:30 am | Group Photo |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RNA Nanoparticles in
Therapeutics |
| Discussion Leader: Stephanie Morris (National Cancer Institute, NIH, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:40 am | Stephanie Morris (National Cancer Institute, NIH, USA) "NCI Support and Resources for Cancer Nanotechnology Research" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Carlo Croce (The Ohio State University, USA) "Causes and Consequences of microRNA Dysregulation in Cancer" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Judy Lieberman (Harvard Medical School, USA) "The Silent Treatment: Knocking Down Cancer" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Mark Evers (University of Kentucky Markey Cancer Center, USA) "Directed RNA Nanoparticle Delivery to Tumor Metastases in the Liver" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Importing from DNA Nanotechnology |
| Discussion Leader: Jorgen Kjems (Aarhus University, Denmark) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Jorgen Kjems (Aarhus University, Denmark) "Self-Assembled Nucleic Acid Nano Structures for Cellular Signaling and Delivery" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Hao Yan (Biodesign Institute at Arizona State University, USA) "Designer DNA Architectures" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Dennis Bong (The Ohio State University, USA) "Bifacial Peptide Nucleic Acid: A Reporter and Allosteric Switch for RNA Function" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structure and Folding of
RNA Nanoparticles |
| Discussion Leader: Eric Westhof (IBMC-CNRS, France) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Eric Westhof (IBMC-CNRS, France) "RNA Puzzles: Progress in Automatic Modelling of RNA Architectures" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Thomas Hermann (University of California, San Diego, USA) "Crystallography of Self-Assembling RNA Nanostructures" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Robert Batey (University of Colorado Boulder, USA) "Reverse Engineering of Biological Riboswitches to Create Novel and Practical Genetically-Encodable Small Molecule Sensors" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Hirohide Saito (Kyoto University, Japan) "Protein-Induced RNA Nanoarchitectures to Control Mammalian Cell Fate" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Ebbe Andersen (Aarhus University, Denmark) "Design Principles for Single-Stranded RNA Origami Structures" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Extracellular RNA for
Therapeutic Development |
| Discussion Leader: Anil Sood (University of Texas M. D. Anderson Cancer Center, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Anil Sood (University of Texas M. D. Anderson Cancer Center, USA) "Novel Delivery Systems for ncRNA" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Huang-Ge Zhang (University of Louisville, USA) "Grapefruit Nanovectors Utilize an Activated Leukocyte Trafficking Pathway for Delivery of Therapeutic Extracellular miRNA to Inflammatory Sites in a Mouse Model" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Thomas Schmittgen (The Ohio State University, USA) "Engineered Microvesicles as Targeted Delivery Agents for Therapeutic microRNAs" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Physical and Chemical
Approaches in RNA Nanotechnology |
| Discussion Leader: Carlo Montemagno (University of Alberta, Canada) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Paula Hammond (Massachusetts Institute of Technology, USA) "RNAi Microsponges and Concatenated RNA: In Vivo Applications for Cancer Therapy" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Farzin Haque (University of Kentucky, USA) "Assembly of Thermodynamically and Chemically Stable RNA Nanoparticles Escorting siRNA, Aptamer and miRNA with Independent Folding for Cancer Targeting" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Kirill Afonin (University of North Carolina, USA) "Conditional Activation of RNAi with Nucleic Acids-Based Nanoparticles" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Zhen Huang (Georgia State University, USA) "Selenium-Nucleic Acids and Chemical and Structural Biology for RNA Nanotechnology" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Shoujun Xiao (Nanjing University, China) "DNA/RNA Nanostructures Based on Small Circular DNA Molecules" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Hui Zhang (University of Kentucky, USA) "Stoichiometry Quantification and Distance Measurement of RNA Nanoparticles by Single-Molecule Photobleaching and FRET" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Mingxu You (Weill Cornell Medical College, USA) "Modular RNA Spinach-Riboswitch Sensor for Metabolite Intracellular Imaging" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Extracellular RNA for
Biomarker Development |
| Discussion Leader: Jan Lotvall (University of Gothenburg, Sweden) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Jan Lotvall (University of Gothenburg, Sweden) "The Diversity of Extracellular Vesicle Subsets and of Extracellular Vesicle
RNA" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:50 pm | Xandra Breakefield (Harvard University / Massachusetts General Hospital, USA) "Part I - ExRNA Consortium;
Part II - Glioblastoma exRNAs - Many Forms and Destinations" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | David Gamm (University of Wisconsin, USA) "Using pRNA Nanoparticles to Advance Stem Cell-Based Therapies for Retinal Disease" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nanotechnologies Relevant
to RNA Research |
| Discussion Leader: Xing-Jie Liang (National Center for Nanoscience and Nanotechnology, China) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:40 am | Carlo Montemagno (University of Alberta, Canada) "Molecular Recognition and Assembly: A New Tool for Solving Grand Societal Challenges" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Paul Rothemund (California Institute of Technology, USA) "Integration of Nucleic Acid Nanotechnology with Microfabrication" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Jong Bum Lee (University of Seoul, South Korea) "RNA-Based Nanovectors for Carrier-Free Nucleic Acid Drug Delivery" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Zicai Liang (Peking University, China) "siRNA Drug Development Against HBV Based on Novel Lipid Nanoparticle RBP131" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nanoimmuology and RNA
Nanotechnology |
| Discussion Leader: David Gamm (University of Wisconsin, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Xiyun Yan (Chinese Academy of Sciences, China) "Getting Nanoparticles Acceptable by Host Immune System" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Xing-Jie Liang (National Center for Nanoscience and Nanotechnology, China) "Nanobiomaterials Used as Immunological Delivery System" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Min Wu (University of North Dakota, USA) "Novel Nanotechnology Approaches for Anti-Gram Negative Bacterial Infection" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |