Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
RNA Folding and Structure
Discussion Leader: Thomas Hermann (University of California, San Diego, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Anna Marie Pyle (Yale University, USA)
"Learning and Applying the Language of RNA Tertiary Interactions: Lessons from High Resolution RNA Structures"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Dan Herschlag (Stanford University, USA)
"From Descriptive to Predictive Understanding: The RNA Reconstitution Model"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Eric Westhof (ARN, IBMC-CNRS, University of Strasbourg, France)
"The Multiple Flavors of GoU Pairs"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Sarah Woodson (Johns Hopkins University, USA)
"RNA Self-Assembly from 5' to 3"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
RNA Nanostructures
Discussion Leader: Kirill Afonin (University of North Carolina at Charlotte, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Luc Jaeger (University of California, Santa Barbara, USA)
"The Ribosome: The Cornerstone for Creating Novel RNA Nanostructures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Peixuan Guo (The Ohio State University, USA)
"Construction of 3D and 4D RNA Nanostructures for Applications in Medical and Material Science"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Susan Schroeder (University of Oklahoma, USA)
"Structures, Dynamics and Metal Ion Binding in Prohead RNA"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
Justin Halman (University of North Carolina at Charlotte, USA)
"Understanding Immunogenic Properties of Nucleic Acid Nanoparticles"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Douglas Zhang (University of California, San Diego, USA)
"Versatile Kit of Robust Nanoshapes from RNA and DNA Modules"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Emil Khisamutdinov (Ball State University, USA)
"Nucleic Acid Nano-Scaffolds Designed from Flexible Tetra-U/T Helix Linking Module"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Yossi Weizmann (The University of Chicago, USA)
"Homooligomeric Self-Assembly Structures Based on a Single RNA Tile"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Louise Laurent (University of California, San Diego, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Modeling and Computation
Discussion Leader: Neocles Leontis (Bowling Green State University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Anne Condon (University of British Columbia, Canada)
"A Model for DNA Structure Kinetics Prediction with Arrhenius Rates"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Bruce Shapiro (National Cancer Institute at Frederick, NIH, USA)
"RNA Nanostructures: Integrating Computation with Experiments"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Cody Geary (California Institute of Technology, USA)
"Computer-Aided Design of Cotranscriptionally-Folding RNA Origami"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Wojciech Kasprzak (Frederick National Laboratory for Cancer Research, National Cancer Institute, NIH, USA)
"Computational Protocol for Ligand Docking to RNA Can Aid in the Design of Ligand-Dependent Nanostructures"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Dmitry Kolpashchikov (University of Central Florida, USA)
"RNA-Cleaving DNA Machines and Logic Gates for Gene Therapy"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biological RNA Nanoparticles
Discussion Leader: Xandra Breakefield (Harvard Medical School / Massachusetts General Hospital, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Dolores Di Vizio (Cedars-Sinai Medical Center, USA)
"Biological Functions and Methods of Detection of Large Oncosomes in Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Louise Laurent (University of California, San Diego, USA)
"Deconvolution Analysis of Small RNAseq Data from exRNAs Reveals Multiple Carrier Subclasses"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"Functional Role of Exosomal DNA and RNA in Cancer"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Naoki Sugimoto (FIBER, Konan University, Japan)
"Molecular Crowding Regulates RNA Phase Separations in Repeat Expansion Disorders"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Jorgen Kjems (Aarhus University, Denmark)
"Self-Assembled Nucleic Acid-Protein-Lipid Devices for Bioimaging and Drug Delivery"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Thomas Tuschl (The Rockefeller University, USA)
"Human RNA Analysis Using a New Reference Transcriptome and Computational Framework"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Stephen Gould (Johns Hopkins University School of Medicine, USA)
"Exosome Biogenesis at Plasma and Endosome Membranes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Based Sensors and Devices
Discussion Leader: Hirohide Saito (Kyoto University, Japan)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Navneet Dogra (IBM Thomas J. Watson Research Center / Icahn School of Medicine at Mount Sinai, USA)
"Liquid Biopsy on a Chip: Circulating Tumor Exosomes' Lineage Tracing Using NanoDLD Chip Technology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Hakho Lee (Massachusetts General Hospital, USA)
"Miniaturized Devices for Nucleic Acid Detection: Robust Sensors for Point-of-Care Applications"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
David Porciani (University of Missouri, USA)
"Modular Cell-Internalizing Aptamer Nanostructures for Targeted Delivery of Large Functional RNAs"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Xinyue Cai (University of California, Santa Barbara, USA)
"Design and Calibration of a Nanoscale Instrument for Dynamic Measurements of Nucleic Acid Bending"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nils Walter (University of Michigan, USA)
"Movers and Shakers: How to Accelerate Nucleic Acid Based Devices"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthetic and Biological Nucleic Acid Based Nanotherapeutics
Discussion Leader: Lydia Contreras (University of Texas at Austin, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Joshua Leonard (Northwestern University, USA)
"Challenges and Opportunities for Engineering Extracellular Vesicles as Therapeutic Delivery Vehicles"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Paul Robbins (University of Minnesota, USA)
"Extracellular Vesicles as Senotherapeutics for Extending Healthspan"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Sangwoo Han (University of Seoul, South Korea)
"Universal Synthetic Technique for Nucleic Acid-Based Nanodetectors and Carrier-Free siRNA Delivery Systems"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Abhichart Krissanaprasit (North Carolina State University, USA)
"Genetically Encoding Functional RNA Origami: Anti-Coagulants"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Jonathan Sczepanski (Texas A&M University, USA)
"Heterochiral DNA Circuitry: Interfacing Mirror-Image DNA with Endogenous Nucleic Acids in Living Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Kendall Van Keuren-Jensen (Translational Genomics Research Institute, USA)
"Towards Biomarkers for CNS Injuries and Neurodegenerative Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eva Rohde (Paracelsus Medical University, Austria)
"The Developmental Path of MSC-EV Therapeutics from Preclinical to Clinical Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Extracellular RNA Based Diagnostics
Discussion Leader: Tushar Patel (Mayo Clinic, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
An Hendrix (Ghent University, Belgium)
"Extracellular Vesicle-Associated Biomarker Discovery in Liquid Biopsies"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
David Wong (University of California, Los Angeles, USA)
"Salivaomics, ExRNA and Liquid Biopsy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Fan Hong (Arizona State University, USA)
"De Novo -Designed Ultra-Specific Riboregulators for Gene Regulation and Low Cost Paper-Based Diagnostics"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Prabodhika Mallikaratchy (Lehman College, City University of New York, USA)
"Ligand-Guided Selection (LIGS): A SELEX Variant to Develop Nucleic Acid Aptamers Against Cell-Surface Markers"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Robert Kitchen (Exosome Diagnostics, USA)
"Current State of Clinical Exosome Based Biomarkers"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Nanotechnology
Discussion Leader: Paul Rothemund (California Institute of Technology, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Hendrik Dietz (Technische Universität München, Germany)
"Molecular Systems Engineering with DNA"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Hanadi Sleiman (McGill University, Canada)
"Amphiphilic DNA Nanostructures: Self-Assembly and Biological Properties"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Kurt Gothelf (iNANO, Aarhus University, Denmark)
"Polymers and Proteins in DNA Nanostructures"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Alexis Vallee-Belisle (Université de Montréal, Canada)
"Recreating Complex Biochemical Mechanisms Using DNA: From Fundamentals to Applications"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Björn Högberg (Karolinska Institute, Sweden)
"Using DNA Origami to Reveal Spatial Effects in Biology"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Oleg Gang (Columbia University / Brookhaven National Laboratory, USA)
"Programming 3D Nanoscale Architectures"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Synthetic Biology
Discussion Leader: Mark Bathe (Massachusetts Institute of Technology, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Beatrix Suess (Technische Universität Darmstadt, Germany)
"RNA Aptamers as Genetic Control Devices: The Potential of Riboswitches as Synthetic Elements for Regulating Gene Expression"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Elisa Franco (University of California, Los Angeles, USA)
"Using RNA to Fuel Dynamic Self-Assembly"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Ebbe Andersen (Aarhus University, Denmark)
"RNA Origami-Based Sensors and Devices In Vivo "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Scott Tenenbaum (SUNY Polytechnic Institute, USA)
"sxRNA: Controlling the Expression of a Therapeutic mRNA Based on the Unique microRNA Profile of a Cell"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Robert Batey (University of Colorado Boulder, USA)
"Small Molecule Activated gRNAs Enable High-Throughput and Multiplex Genome Editing in E. coli by Cas9"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure