Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Immunogenicity of RNA Nanoparticles
Discussion Leader: Xin Li (The Ohio State University, USA)
3:45 pm - 4:10 pm
Kirill Afonin (University of North Carolina at Charlotte, USA)
"Immunomodulation in RNA Nanotechnology"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Justin Halman (University of North Carolina at Charlotte, USA)
"Understanding Immunogenic Properties of Nucleic Acid Nanoparticles"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic and Diagnostic Applications of RNA Nanoparticles
Discussion Leader: Shi Chen (University of California, San Diego, USA)
7:30 pm - 7:40 pm
Congcong Xu (The Ohio State University, USA)
"Photo-Controlled Release of Paclitaxel and Model Drugs from RNA Pyramids"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Weina Ke (University of North Carolina at Charlotte, USA)
"RNA-DNA Fibers and Polygons with Controlled Immunogenicity Can Activate RNAi and Transcriptional Regulation of NF-kB"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Zhefeng Li (The Ohio State University, USA)
"Arrowtail RNA for Ligand Display on Ginger Exosome-Like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Pranav Tripathi (Motilal Nehru National Institute of Technology Allahabad, India)
"Screening, Selection and Characterization of Aptamers Against Ovarian Cancer Biomarker CA125"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Morgan Chandler (University of North Carolina at Charlotte, USA)
"Bioresponsive Quantum Dot Lattices for Applications in Biosensing and Conditionally Activated RNA Interference"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Sangwoo Han (University of Seoul, South Korea)
"Universal Synthetic Technique of Nucleic Acid-Based Nanodetectors and Carrier-Free siRNA Delivery System"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Erika Urdaneta (Humboldt University of Berlin, Germany)
"PTex: A Rapid and Unbiased Method for Cell-Wide Purification of Crosslinked RNA-Protein Complexes in Human and Bacteria"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kate Qi (Nanyang Technological University, Singapore)
"Rapid, Affordable, Ultra-Sensitive Food Pathogen Biosensor, with Emphasis on Industrial Applicability"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Structural RNA Studies
Discussion Leader: Alejandra Matsuri Rojano Nisimura (University of Texas at Austin, USA)
9:00 am - 9:10 am
Anna Graczyk (Polish Academy of Sciences, Poland)
"Metal Nanoparticles Capped with Structured RNA: The Spherical Incarnation of TectoRNA"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Madhuri Hande (University of Turku, Finland)
"Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Maryam Hosseini (Bowling Green State University, USA)
"Comprehensive and Consistent Identification, Annotation, Extraction and Classification of RNA Multi-Helix Junction (MHJ) for Use in Nanotechnology Applications"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Kaiming Zhang (Stanford University, USA)
"Cryo-EM Structure of Type III-A CRISPR-Cas Csm Complex"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sijin Guo (The Ohio State University, USA)
"Effects of RNA Nanoparticle Size, Shape, Structure, Sequence and Surface Chemistry on Biodistribution, Immunogenicity and Endosome Escape"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Molly Parsons (Massachusetts Institute of Technology, USA)
"A DNA Origami Platform for RNA Tertiary Structure Elucidation"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Emanuela Torelli (Newcastle University, United Kingdom)
"Walk on the Origami Side: From Switchable DNA Nanodevices to Light-up Bio-Orthogonal RNA Nanoribbon"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Floris Engelhardt (Technische Universität München, Germany)
"Expanding the Design Space of DNA Origami with Functional and Orthogonal Custom Scaffolds"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
This panel consists of laboratory leaders, research center directors, and industry scientists.
Discussion Leader: Paul Zakrevsky (National Cancer Institute, NIH, USA)
1:30 pm - 2:30 pm
Panel Discussion
Career Advice from Leaders in the Field
Kirill Afonin (University of North Carolina at Charlotte, USA)
Jorgen Kjems (Aarhus University, Denmark)
Scott Tenenbaum (SUNY Polytechnic Institute, USA)
Arkadiusz Chworos (Polish Academy of Sciences, Poland)
Victoria Portnoy (System Biosciences (SBI), USA)
Kate Qi (Nanyang Technological University, Singapore)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
