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RNA Nanotechnology (GRS)

Gordon Research Seminar

Delivery, Design and Function of RNA Nanostructures

January 7 - 8, 2023
Chairs Morgan Chandler and Anna Graczyk
Four Points Sheraton / Holiday Inn Express
1050 Schooner Drive
Ventura, California, United States
 Venue and Travel Information

Conference Description

The RNA Nanotechnology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2023 GRS will focus on major areas pertaining to the design of RNA into rationally designed nanostructures. Sessions will follow the developmental pipeline from computational and structural design to use in applications as diagnostics, therapeutics, and materials. Challenges facing the field, including the cellular delivery of these formulations and the immune stimulation of nucleic acid-based nanostructures, will also be explored. The schedule will include talks on research findings as well as poster presentations to drive discussion on these topics and beyond.

Related Meeting

This GRS will be held in conjunction with the "RNA Nanotechnology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Functional Nucleic Acid Nanoparticles
Discussion Leader: Nestor Sampedro (Aarhus University, Denmark)
3:45 pm - 4:10 pm
Jaimie Stewart (California Institute of Technology, United States)
"Functional Nucleic Acid Nanoparticles"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Samuel Schaffter (National Institute of Standards and Technology, United States)
"Cotranscriptionally Encoded RNA Strand Displacement Circuits for Engineering Biology"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational, Structural, and Mechanistic Studies of Nucleic Acids
Discussion Leaders: Marco Todisco (HHMI/University of Chicago, United States)
7:30 pm - 7:40 pm
Emanuela Torelli (Newcastle University, United Kingdom)
"Co-transcriptionally Folded RNA Origami and DNA Stack Memory as Potential Interfaces Able to Operate In Vivo"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Lewis Rolband (University of North Carolina at Charlotte, United States)
"SAXS for NANPs: Advancing the Structural Characterization of Nucleic Acid Nanoparticles Through Small-angle X-ray Scattering"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Byunghwa Kang (Pohang University of Science and Technology (POSTECH), South Korea)
"In Vitro Evolution with Rationally-Designed RNA Library: Generation of Smallest Trans-Acting Ligase Ribozyme that Enables RNA Concatenation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Kai Sheng (The Scripps Research Institute, United States)
"Unsupervised Voxel-based Segmentation reveals a Landscape of Bacterial Ribosome Large Subunit Early Assembly"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Olivia Zou (California Institute of Technology, United States)
"Engineering DNA Liquids for Macroscopic Separation of Biomolecules"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
David Bushhouse (Northwestern University, United States)
"Expression Platform Features Tune Functional Characteristics of the Clostridium beijerinckii ZTP Riboswitch"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Edric Choi (Northwestern University, United States)
"Deducing RNA Structure and Dynamics from Quantitative Analysis of Chemical Probing Reactivities"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Everett Kengmana (Johns Hopkins University, United States)
"Engineering DNA Droplet-Droplet Signaling via Transcription"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
RNA Nanomaterials in Therapy and Medicine
Discussion Leaders: Aleksandar Radakovic (Harvard University, United States)
9:00 am - 9:10 am
Michael Dore (Northwestern University, United States)
"mRNA and Peptide Amphiphile Nanofibers"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Grant Knappe (Massachusetts Institute of Technology, United States)
"Functionalizing Nucleic Acid Nanoparticles for the Delivery of Nucleic Acid Therapeutics"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Vincent Clark (Johns Hopkins University, United States)
"Development of an Aptamer Based Sensor for Point of Care Monitoring of Antiretroviral Therapy"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
B.J. (Byungji) Kim (MIT, United States)
"Role of the Type 1 Interferon Response in Humoral Immunity Elicited by Self-Replicating RNA Vaccines"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Anna Romanov (MIT Biological Engineering, United States)
"A DNA-scaffolded Vaccine Platform for Programmable Presentation of Engineered HIV Immunogens"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Emily Helm (Johns Hopkins University, United States)
"Engineering Reusable Synthetic RNA Strand Displacement Circuits"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Matthew Allan (Massachusetts Institute of Technology, United States)
"3D RNA-Scaffolded Wireframe Origami"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Lan Mi (University of Massachusetts, Amherst, United States)
"Genetically Encoded Fluorogenic RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors for Cellular Imaging and Target Detection"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: The Next Generation of RNA Therapeutics
Discussion Leader: Laura Hertz (Northwestern University, United States)
1:30 pm - 2:30 pm
Panel Discussion
The Next Generation of RNA Therapeutics
  • Emil Khisamutdinov (Ball State University, United States)
  • Scott Tenenbaum (SUNY Polytechnic Institute, United States)
  • Mira Moufarrej (The Column Group, United States)
  • Lorena Parlea (GSK VACCINES, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health - National Cancer Institute (NCI)
National Institutes of Health - National Center for Advancing Translational Sciences (NCATS)

Research reported in this publication was supported by the National Cancer Institute and the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number R13CA277856. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History RNA Nanotechnology
Additional Fee Info

RNA Nanotechnology
January 5 - 10, 2025


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