SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff Welcome from Masataka Murakami and Matthew Hoffman |
7:40 pm - 9:30 pm | Salivary, Pancreas, and Lacrimal Keynote Presentations |
7:40 pm - 7:45 pm | Discussion Leader: Maria A. Kukuruzinska (Boston University) "Introduction" |
7:45 pm - 8:10 pm | Kenneth M. Yamada (NIDCR, National Institutes of Health)
"Cell and tissue dynamics" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Ray J. MacDonald (University of Texas Southwestern)
"Development of the acinar pancreas; transcriptional control and ChIP-Seq analysis" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Darlene A. Dartt (Harvard University)
"P2X receptors in lacrimal gland: Role in secretion and disease" |
9:20 pm - 9:30 | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Molecular mechanisms of Exocrine Secretion |
| Discussion Leader: Mary E. Reyland (University of Colorado Health Sciences Center) |
9:00 am - 9:20 am | Roberto Weigert (NIDCR, National Institutes of Health)
"A role for the acto-myosin complex in regulated exocytosis revealed by intravital microscopy" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sarah F. Hamm-Alvarez (University of Southern California)
"Cross talk between transcytotic and exocytotic membrane trafficking in lacrimal gland acinar cells |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Miwako Matsuki-Fukushima (School of Dentistry at Matsudo, Japan)
"Aquaporin-6 is involved in osmoregulation of rat parotid secretory granules" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Debbie J. Andrew (Johns Hopkins University)
"Gene regulation in the early Drosophila salivary gland: Morphogenesis, secretion and cell-type specialization" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Shmuel Muallem (University of Texas Southwestern)
"HCO3-secretion" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Rebecca M. Fox (Johns Hopkins University)
"The CrebA/Creb3-like transcription factors are required to boost the secretory capacity of specialized secretory organs" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Lorena B. De Souza (São Paulo University, Brazil)
"PLD is involved in the formation of golgi associated clathrin coated vesicles in intercalated duct cells of parotid gland" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sumit Bhattacharya (Univerity of Toledo)
"Differential effects of P2X4 and P2X7 receptor activations on Ca2+ signaling and exocytosis in mouse parotid acinar cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (Odd numbered posters presented) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tumor Biology, Diseases, and Diagnostics |
| Discussion Leader: David T. Wong (UCLA School of Dentistry) |
7:30 pm - 7:50 pm | Kirsten H. Limesand (University of Arizona)
"Signaling pathways involved in radiation-induced salivary gland dysfunction" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | V.P. Eswarakumar (Yale University)
"Molecular mechanisms of salivary gland hypoplasia" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | John McDevitt (Rice University)
"Next generation diagnostic devices based on bio-nano-chips" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Jieping Yang (University of California Los Angeles)
"Mechanism underlying salivary diagnostics for systemic diseases: the contribution of disease-derived exosomes" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Anne M. Rowzee (NIDCR, National Institutes of Health)
"Salivary glands are useful target organs for gene therapy of diabetes mellitus" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Systems Biology |
| Discussion Leader: Melinda Larsen (University at Albany) |
9:00 am - 9:20 am | James Sneyd (Auckland University, New Zealand)
"Modelling saliva secretion at multiple scales" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Yoshiro Sohma (Keio University School of Medicine, Japan)
"Direct measurement and simulation of water movement: a novel approach to water transport physiology" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Markus Hardt (Boston Biomedical Research Institute)
"Absolute quantification of endogenous salivary peptides using high resolution selected reaction monitoring mass spectrometry" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Ivan T. Rebustini (NIDCR, National Institutes of Health)
"MicroRNAs regulate proliferation and cell fate decisions" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Kasia A. Rejniak (Moffitt Cancer Center)
"Intrinsic and extrinsic mechanisms in epithelial gland formation: an integrated model" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Steve Horvath (University of California Los Angeles)
"Studying gene co-expression modules related to Sjogrens syndrome" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Melissa A. Metzler (University of Louisville)
"MicroRNA changes in parotid gland acinar differentiation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (Even numbered posters presented) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Exocrine Glycobiology |
| Discussion Leader: Sarah M. Knox (NIDCR, National Institutes of Health) |
7:30 pm - 7:50 pm | Maria A. Kukuruzinska (Boston University)
"Interplay among protein N-glycosylation, Wnt signaling, and E-cadherin-mediated cell-cell adhesion" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kelly TenHagen (NIDCR, National Institutes of Health)
"Protein O-glycosylation in developmentally regulated cell adhesion and organogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | J. Michael Pierce (University of Georgia)
"Application of technologies for the glycomics of stem and cancer cells to identify biomarkers" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Steven Leach (Johns Hopkins University)
"Finding the center: Centroacinar progenitors in mouse and zebrafish pancreas" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation and Autoimmunity |
| Discussion Leader: Darlene Dartt |
9:00 am - 9:20 am | Ilias Alevizos (NIDCR, National Institutes of Health)
"MicroRNAs as biomarkers of inflammation and salivary gland dysfunction in Sjögren's syndrome" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hiroshi Ishiguro (Nagoya University Japan)
"Pancreatic duct dysfunction and pancreatitis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Sreedevi Chinthamani (University of Buffalo)
"Lipoxin inhibits immune cell adherence and rolling in salivary epithelium and vascular endothelium" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Gary Weisman (University of Missouri)
"P2 nucleotide receptors: balancing salivary gland inflammation and regeneration" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Seunghee Cha (University of Florida)
"Innate immunity and secretory dysfunction in Sjögren's syndrome" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Kwong Tai Oscar Cheng (NIDCR, National Institutes of Health)
"Targeted deletion STIM1 and STIM2 in T lymphocytes leads to Sjögren's Syndrome-like salivary gland autoimmune disease" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Olutayo A. Odusanwo (University of Buffalo)
"D series Resolvins (RvDs) prevent TNF α-mediated disruption of monolayer formation in salivary epithelium" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Julian L. Ambrus (Buffalo General Hospital)
"Use of IL14α transgenic mice in the study of Sjogren's disease" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (General poster viewing) |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Epithelial Progenitor Cell Biology |
| Discussion Leader: Isabelle M.A. Lombaert (NIDCR, National Institutes of Health) |
7:30 pm - 7:50 pm | Sarah M. Knox (NIDCR, National Institutes of Health)
"A little bit nervous? Parasympathetic innervation regulates epithelial progenitor cells" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Fei Liu (Texas A&M Health Sciences Center)
"Modulating Wnt and hedgehog pathways for functional restoration of salivary glands" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Catherine E. Ovitt (University of Rochester)
"Ascl3 as a marker of adult progenitor cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Abigail S. Tucker (Kings College London, UK)
"Epithelial-mesenchymal interactions during salivary gland initiation" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jeff C. Hsu (NIDCR, National Institutes of Health)
"Development of complementary approaches to probe epithelial plasticity in developing mouse salivary glands" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signal Transduction and Exocrine Gland Function |
| Discussion Leader: David Yule (University of Rochester) |
9:00 am - 9:20 am | James W. Putney (NIEHS, National Institutes of Health)
"Physiological function of store-operated calcium channels in epithelia and other non-excitable cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Lily Jan (University of California San Francisco)
"Getting to know the TMEM16 family" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Stephen P. Soltoff (Harvard University)
"Regulation and identification of the Na,K-ATPase alpha 1 subunit phosphorylation in rat parotid acinar cells" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Hiroshi Sugiya (Nihon University, Japan)
"cAMP-dependent exocytosis in parotid acinar cells" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Akihiko Tanimura (Health Sciences University of Hokkaido, Japan)
"Roles of purinergic receptors on the spontaneous and agonist-induced Ca2+ responses in rat salivary ducts" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Fei Wei (National Institute for Natural Sciences, Japan)
"Salivary fluid secretion induced by Chinese herb, DanShen" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Marit H. Aure (University of Oslo, Norway)
"Aquaporins in the mouse sublingual salivary gland" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Nataliya V. Fedirko (Bogomoletz Institute of Physiology, Ukraine)
"CB1 and CB2 receptors in submandibular acinar cells: functional coupling between basal fluid and electrolytes secretion and Ca2+ signaling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session (General poster viewing) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regeneration and iPS Cells |
| Discussion Leader: Indu S. Ambudkar (NIDCR, National Institutes of Health) |
7:30 pm - 7:50 pm | Tetsuya Kawakita (Keio University, Japan)
"Lacrimal gland regeneration" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Ana Cotrim (NIDCR, National Institutes of Health)
"Transfer of human aquaporin-1 cDNA to correct radiation-induced salivary hypofunction" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Sharon J. Sequeira (University at Albany)
"Nanoscale topography of 3D artificial scaffolds regulates salivary gland epithelial cell morphology and focal adhesion complex formation" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Kazuo Komiyama (Nihon University, Japan)
"Epiregulin regulates acinar cell regeneration process in mouse submandibular gland" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Rob P. Coppes (University of Groningen, Netherlands)
"The development of stem cell therapy to reduce radiation-induced hyposalivation" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |