SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Opening Keynote Presentation |
| Discussion Leaders: Indu Ambudkar (NIDCR) and Maria Kukuruzinska (Boston University)
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7:30 pm - 7:45 pm | Introduction |
7:45 pm - 8:30 pm | Elisabetta Dejana (University of Milan, Italy)
"Transcriptional regulation of endothelial cell differentiation"
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8:30 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Development |
| Discussion Leaders: Deborah Andrew (John Hopkins University) and Catherine Ovitt (University of Rochester)
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9:00 am - 9:20 am | Wellington Cardoso (Boston University)
"Regulation of Cell Fate and Diversity in Secretory Progenitors in Developing Airways"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jennifer Zallen (Sloan Kettering Institute)
"Cellular dynamics in development"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Takayoshi Sakai (Osaka University Graduate School of Dentistry)
"Melatonin regulates the branching morphogenesis of embryonic salivary glands by adjusting the adhesion and morphology of epithelial cells" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Matthew Hoffman (NIDCR)
"Progenitor cell communication during submandibular gland development" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Ray MacDonald (University of Texas Southwestern)
"Transcriptional Control of the Acinar Phenotype"
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11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Poster Talk: Farid El-Sayed (University of Missouri - Columbia)
"The Role of the P2Y2 Nucleotide Receptor in Salivary Gland Regeneration" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Celeste Nelson (Princeton University)
"Mechanical control of branching morphogenesis"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Spatial and Molecular Determinants of Protein Trafficking and Secretion |
| Discussion Leaders: Mary Reyland (University of Colorado) and Gary Weisman (University of Missouri)
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7:30 pm - 7:50 pm | Roberto Weigert (NIDCR)
"Regulated exocytosis in exocrine glands in live animals"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Ian Mather (University of Maryland)
"Intra-vital imaging of milk secretion"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Sarah Hamm-Alvarez (University Southern California)
"Determinants of the fidelity of secretory protein sorting: insights from knockout mouse models"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Guy Groblewski (University of Wisconsin)
"Endolysosomal membrane trafficking controls zymogen granule secretory polarity and pancreatitis responses in pancreatic acinar cells"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Calcium Signals and Spatial Compartmentalization |
| Discussion Leaders: Jim Melvin (NIDCR) and Masataka Murakami (National Institute of Physiological Sciences, Japan)
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9:00 am - 9:20 am | David Yule (University of Rochester)
"Polarization of Signals and Effectors in Salivary Acinar cells"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Brij Singh (University of North Dakota)
"Calcium and saliva secretion: old saga, but new players"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Kietaro Satoh (Dokkyo Medical University, Japan)
"Effects of a naturally occurring point mutation of AQP5 on carbachol-induced volume decrease and on the activation energy for water transport by rat parotid acinar cells" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Aldebaran Hofer (Veterans Affairs, Boston)
"New twists on Ca2+-dependent cAMP signaling"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Rajini Rao (Johns Hopkins University)
"Secretory Pathway Calcium ATPases in Golgi and Post-Golgi Compartments: Role in Mammary glands and Breast Tumors"
|
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Poster Talk: Yoshinori Sahara (Iwate Medical University School of Dentistry, Japan)
"The function of V-ATPases in salivary glands of mouse" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Sandip Patel (University College London)
"NAADP, two-pore channels and complex calcium signalling" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of Electrolyte and Water Transport |
| Discussion Leaders: David Yule (University of Rochester) and Brij Singh (University of North Dakota)
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7:30 pm - 7:50 pm | Min Goo Lee (Younsei College of Medicine, Korea)
"Dynamic regulation of anion permeability of CFTR and ANO1 anion channels"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Thomas Jentsch (Leibniz-Institut, Germany)
"Role of Cl transport in epithelial function" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ivana Novak (University of Copehhagen, Denmark)
"Role of Purinergic signalling in pancreatic function"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Shmuel Muallem (NIDCR)
"Synergism in epithelial fluid and bicarbonate secretion"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Salivary Gland Dysfunction I: Inflammation, Autoimmunity, and Fibrosis |
| Discussion Leaders: David Ann (City of Hope/Beckman Research Institute) and Denise Faustman (Harvard University)
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9:00 am - 9:20 am | Antony Rosen (John Hopkins University)
"Interactions of interferons and cytotoxic lymphocyte granule pathways in Sjogren's syndrome in humans: Implications for pathogenesis"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Roland Jonson (University of Bergen, Norway)
"Exploring the complex pathogenesis of Sjögren's syndrome"
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9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Andrew McCall (University at Buffalo)
"Vascular and lymphatic remodeling in salivary glands with Sjögren's Syndrome" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Ilias Alveizos (NIDCR)
"MicroRNA alterations in Sjogren's syndrome" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Maria Trojanowska (Boston University)
"Endothelial dysfunction in tissue repair and fibrosis"
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11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Poster Talk: Scott Lieberman (The Children's Hospital of Philadelphia)
"Sex-specific regulatory T cell dysfunction in a mouse model of Sjögren syndrome" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Austin Mircheff (University of Southern California)
"Each Lacrimal Gland is a System in Which Immune Cells Performing Diverse Functions Interact with Each Other and with Acinar- and Ductal Epithelial Cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Salivary Gland Dysfunction II: Cancer |
| Discussion Leaders: Silvio Gutkind (NIDCR ) and Maria Trojanowska (Boston University)
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7:30 pm - 7:50 pm | Jacques Nor (University of Michigan)
"Salivary gland cancer stem cells"
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7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Peter Friedl (Radboud University, Netherlands)
"Collective invasion of epithelial and mesenchymal cancer cells"
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8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Patrick Ha (John Hopkins University)
"Promoter Methylation Alterations in Adenoid Cystic Carcinoma"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jeff Meyers (The University of Texas)
"Head and Neck Cancer Genomics as a Gateway to Personalizing Treatment Decisions"
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9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Salivary Gland Repair and Regeneration |
| Discussion Leaders: Austin Mircheff (University of Southern California) and Sarah Hamm-Alvarez (University of Southern California) |
9:00 am - 9:20 am | Cara Gottardi (Northwestern University)
"Adhesion and signaling through the cadherin/catenin system"
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9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sue Menko (Thomas Jefferson University)
"Novel paradigms of epithelial wound repair - implications for the submandibular gland" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Poster Talk: Nan Xiao (Stanford University)
"Characterizing a new population of adult mouse submandibular gland stem cells" |
10:10 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:05 am | Melinda Larsen (SUNY, Albany)
"Advances Towards Salivary Gland Tissue Engineering" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Catherine Ovitt (University of Rochester)
"Gene targeting in the salivary glands using siRNA/nanoparticle complexes"
|
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Poster Talk: Kirsten Limesand (University of Arizona)
"Prevention of Radiation-Induced Salivary Gland Dysfunction Utilizing a CDK Inhibitor" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Jay Chiorini (NIDCR)
"Spit, Genes, and Viruses: A New Approach to the Treatment of Xerostomia" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Closing Keynote Presentation |
| Discussion Leaders: Indu Ambudkar (NIDCR) and Maria Kukuruzinska (Boston University)
|
7:30 pm - 7:45 pm | Introduction |
7:45 pm - 8:30 pm | Kenneth Yamada (NIDCR)
"Cell-Matrix Dynamics" |
8:30 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |