Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Perspectives, Epithelial Polarity and Gland Morphogenesis |
| Discussion Leaders: Catherine Ovitt (University of Rochester, USA) and Gary Weisman (University of Missouri, USA) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 7:55 pm | Keynote: Lawrence Tabak (National Institute of Dental and Craniofacial Research, NIH, USA) "Opening Remarks" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:40 pm | Keynote: Elizabeth Knust (Max-Planck-Institute MPI-CBG, Germany) "Epithelial Polarity, Signaling and Morphogenesis" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:25 pm | Keynote: Matthew Hoffman (National Institute of Dental and Craniofacial Research, NIH, USA) "FGF-Dependent Wnt Signals Regulate Epithelial Progenitor-Neuronal Interactions During Development" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Glycobiology, Mucins and Epithelial Barriers |
| Discussion Leader: Lawrence Tabak (National Institute of Dental and Craniofacial Research, NIH, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Mary Callaghan Rose (Children's National Medical Center, USA) "Secretory Mucins: A Novel Therapeutic Approach to Decrease Mucin Overproduction in Lung Diseases" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Jerrold Turner (The University of Chicago, USA) "Tight Junction Permeability: Mechanisms and Regulation" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Selected from Poster Abstracts: Marit Aure (University of Rochester, USA) "Salivary Gland Homeostasis Is Maintained Through Acinar Cell Self-Duplication" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Selected from Poster Abstracts: Seyeon Chung (Johns Hopkins University School of Medicine, USA) "Mechanism of Epithelial Invagination in the Drosophila Salivary Gland" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Gunnar C. Hansson (Goteborg University, Sweden) "Mucin Structure, Packing, and Granulae Exocytosis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Katharina Ribbeck (Massachusetts Institute of Technology, USA) "Probing the Influence of Salivary Mucins on Oral Streptococci Physiology" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Elaine Emmerson (University of California, San Francisco, USA) "Sox2 Is Necessary for Salivary Gland Development and Is Maintained by Parasympathetic Innervation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: William Daley (National Institute of Dental and Craniofacial Research, NIH, USA) "Btbd7 Is a Master Regulator of Epithelial Cell Dynamics and Cell Adhesion During In Vivo Branching Morphogenesis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Secretory Organ Development |
| Discussion Leaders: Kenneth Yamada (National Institute of Dental and Craniofacial Research, NIH, USA) and Darlene Dartt (Schepens Eye Research Institute, USA) |
7:30 pm - 7:50 pm | Cathrin Brisken (Ecole Polytechnique Federale de Lausanne, Switzerland) "How Hormones Orchestrate Mammary Gland Development" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Maria Kukuruzinska (Boston University, USA) "Cell Polarity Cues Guiding Ductal Tree Patterning During Submandibular Gland Branching Morphogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ondine Cleaver (University of Texas Southwestern Medical Center, USA) "Epithelial Stratification and Branch Formation During Pancreas Development" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Seung Kim (Stanford University School of Medicine, USA) "Integrated Plasticity of Pancreatic Exocrine and Endocrine Cell Fate and Function" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Protein Secretion |
| Discussion Leaders: Sarah Hamm-Alvarez (University of Southern California, USA) and Sarah Knox (University of California, San Francisco, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Duy Tran (National Institute of Dental and Craniofacial Research, NIH, USA) "Real Time Imaging of Dynamic Secretory Events to Define Essential Genes Involved in Regulated Secretion" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Ben-Zion Shilo (Weizmann Institute, Israel) "Content Release of Large Secretory Vesicles by the Actomyosin Network" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Selected from Poster Abstracts: Arash Bashirullah (University of Wisconsin, Madison, USA) "Caspase-Dependent Control of Tissue Elasticity During Salivary Gland Secretion in Drosophila" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Selected from Poster Abstracts: Soonhong Park (Yonsei University College of Dentistry, South Korea) "Modifications of Regulated Exocytosis in TRPML1 Knock-Out Mice" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Manfred Frick (University of Ulm, Germany) "Mechanisms Driving Actin-Dependent Compression of Fused Secretory Vesicles for Efficient Secretion of Pulmonary Surfactant" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Antonella De Matteis (Telethon Institute of Genetics and Medicine, Italy) "The Phosphoinositides and the Golgi Complex" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Gaspar Pena-Munzenmayer (National Institute of Dental and Craniofacial Research, NIH, USA) "Ae4 (Slc4a9) Anion Exchangers Drive Cl- Uptake-Dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Swati Pradhan-Bhatt (University of Delaware, Helen F. Graham Cancer Center, USA) "Building Salivary Cell Mini-Modules: A First Step Toward Reconstruction of the Human Salivary Gland" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Fluid Secretion and Signaling |
| Discussion Leaders: Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA) and David Yule (University of Rochester, USA) |
7:30 pm - 7:50 pm | Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA) "Role
of STIM2 in Agonist-Sensitivity of Cellular Ca2+ Response" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | James Sneyd (University of Auckland, New Zealand) "Mathematical Modeling of Saliva Secretion: Is a Multiscale Model Really
Necessary?" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Alexey Tepikin (University of Liverpool, United Kingdom) "Ca2+ Signaling and Pathophysiology of Pancreatic Acinar Cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Mark Donowitz (Johns Hopkins University School of Medicine, USA) "NHE3 Regulation by Signaling Complexes that Form on Its Intracellular
Domain" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host-Pathogen Immunity |
| Discussion Leaders: Ilias Alevizos (National Institute of Dental and Craniofacial Research, NIH, USA) and Austin Mircheff (University of Southern California, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Stefan Ruhl (University at Buffalo, USA) "Evolution of Muc5 in Primates" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Daniel Malamud (New York University College of Dentistry, USA) "Innate Immune Factors in Exocrine Secretions" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Selected from Poster Abstracts: Jonathan Axelrod (Hadassah Hebrew University Hospital, Israel) "Cellular Senescence Drives Radiation-Induced Loss of Salivary Gland Function and Is Prevented by Modulation of IL-6" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Selected from Poster Abstracts: Soosan Ghazizadeh (Stony Brook University, USA) "Keratin 14 Is a Biomarker of Ductal Stem Cells in Adult Mouse Submandibular Gland" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Julian Ambrus (State University of New York, Buffalo, School of Medicine, USA) "Lessons Learned Regarding Sjogren's Syndrome from the IL-14 Alpha Transgenic Mouse" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ammon Peck (University of Florida, USA) "Salivary Gland Autoimmunity: Is It Just a Virus or a Matter
of TAM RTK Dysfunction?" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Zhen Meng (University of Southern California, USA) "Changes in Lacrimal Acinar Cell Cathepsin S and Cystatin C Expression and Sorting in Sjögren’s Syndrome Are Correlated with Increased Expression of Components of MHC II-Mediated Antigen Presentation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Lucas Woods (University of Missouri, USA) "P2Y2R Deletion Ameliorates the Autoimmune Phenotype in IL-14a-Overexpressing Mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Cutting Edge Technologies as Applied to Secretory Biology and Disease |
| Discussion Leader: Jay Chiorini (National Institute of Dental and Craniofacial Research, NIH, USA) |
7:30 pm - 7:50 pm | David Wong (University of California, Los Angeles, USA) "Exosomes and Extracellular RNA in Salivary Biomarker Development" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Prashant Mali (University of California, San Diego, USA) "Engineering Large-Scale Genetic Perturbations Using the CRISPR-Cas9 System" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Natalie Porat-Shliom (National Institute of Dental and Craniofacial Research, NIH, USA) "Intravital Microscopy Reveals Novel Aspects of Salivary Glands Bioenergetics" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | George Patterson (National Institute of Biomedical Imaging and Bioengineering, NIH, USA) "Higher and Deeper: Multi-Photon Super-Resolution for Tissue Imaging" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Design Flaws - Auto-Immunity in Epithelial Organs |
| Discussion Leaders: Susan Menko (Thomas Jefferson University, USA) and Melinda Larsen (State University of New York, Albany, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Mary Reyland (University of Colorado, USA) "PKCdelta as a Target for Radio Protection of the Salivary Gland" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Olga Baker (University of Utah School of Medicine, USA) "Current Techniques to Restore Salivary Gland Dysfunction" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Denise Faustman (Massachusetts General Hospital / Harvard University, USA) "Translation in Sjogren's Syndrome: Direct Applications of Basic Science
to Human Trials" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | David Ann (City of Hope National Medical Center, USA) "Genetically Engineered Mouse Model in Salivary Gland Homeostatic Control and Tumorigenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Selected from Poster Abstracts: Sarah Pringle (University Medical Center Groningen, The Netherlands) "Human Salisphere Cells Functionally Restore Radiation Damaged Salivary Glands" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: Isabelle Miletich (Guy's Hospital, London, United Kingdom) "Role of the Mesenchyme in Salivary Gland Regeneration" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Aryan Vissink (University Medical Center Groningen, The Netherlands) "What Have We Learned from Clinical Studies in Sjögren's Syndrome?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Clathrin-Mediated Endocytosis |
| Discussion Leaders: Deborah Andrew (Johns Hopkins University, USA) and Roberto Weigert (National Institute of Dental and Craniofacial Research, NIH, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:30 pm | Sandra Schmid (University of Texas Southwestern Medical Center, USA) "Regulation of
Clathrin-Mediated Endocytosis: Why and How" |
8:30 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | General Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |