Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Frontiers in Tissue Engineering
Discussion Leaders: Gary Weisman (University of Missouri, USA) and Catherine Ovitt (University of Rochester, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
David Mooney (John A. Paulson School of Engineering and Applied Sciences, Harvard University, USA)
"Improving Stem Cell Therapeutics with Mechanobiology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Linda Griffith (Massachusetts Institute of Technology, USA)
"Decoding Epithelial-Stromal Cross Talk with Synthetic Extracellular Matrix"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Exocrine Gland Development
Discussion Leaders: Deborah Andrew (Johns Hopkins School of Medicine, USA) and Matthew Hoffman (National Institute of Dental and Craniofacial Research, NIH, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Helen Makarenkova (The Scripps Research Institute, USA)
"The Dynamics of Murine Lacrimal Gland Stem/Progenitor Cells During Development, Homeostasis and Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Lisa Sandell (University of Louisville, USA)
"Signaling by the Vitamin A Derivative Retinoic
Acid Regulates Development of Submandibular Salivary Epithelium"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Aaron Mattingly (University of California, San Francisco, USA)
"Neuregulin-1/ERBB3 Signaling Is Essential for Mouse Salivary Gland Development and Acinar Cell Formation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Rose-Anne Romano (State University of New York at Buffalo, USA)
"Chromatin Fingerprinting of Enhancers and Super-Enhancers in the Control of Cell Fate and Identity in the Salivary Gland"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Abigail Tucker (King's College London, United Kingdom)
"Fgf10 and Sox9 Interactions in Developing Salivary Glands"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Kenneth Yamada (National Institute of Dental and Craniofacial Research, NIH, USA)
"3D Dynamics of Cells and Matrix in Branching
Morphogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Akiko Shitara (National Institutes of Health, USA)
"Cdc42 Is Required for the Maintenance and Formation of Apical Lumens in Tubular Organs"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Bob Varelas (Boston University School of Medicine, USA)
"The Hippo Pathway Effector YAP Is an Essential Regulator of Submandibular Gland Ductal Progenitor Patterning"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Concepts in Regenerative Medicine
Discussion Leaders: Darlene Dartt (Schepens Eye Research Institute, Harvard Medical School, USA) and Mary Farach-Carson (University of Texas Health Science Center at Houston, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Quynh-Thu Le (Stanford University, USA)
"Activating the ALDH3 Pathway to Mitigate Radiation-Related Xerostomia"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Driss Zoukhri (Tufts University, USA)
"Mechanisms
of Lacrimal Gland Repair"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Danielle Benoit (University of Rochester, USA)
"Tunable Hydrogel Microenvironments to Study Salivary Gland Cell Phenotype and Function"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Melinda Larsen (University at Albany, SUNY, USA)
"From Developmental Mechanisms to Regenerative Strategies"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Relevance of Mucins and Salivary
Proteins
Discussion Leaders: Mary Reyland (University of Colorado Denver, USA) and Stefan Ruhl (University at Buffalo, SUNY, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Gordon Proctor (King's College London, United Kingdom)
"Salivary Mucin Interaction with Mucosal Surfaces"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Paul Breslin (Rutgers University, USA)
"The Role of Salivary Amylase in Taste and Regulatory Physiology"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Joao Ferreira (National University of Singapore, Singapore)
"Three-Dimensional Bioprinting Nanotechnologies for the Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Omer Gokcumen (State University of New York at Buffalo, USA)
"Archaic Hominin Introgression and Microbial Interactions Shaped Extant Salivary MUC7 Variants in Modern Humans"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eva Helmerhorst (Boston University, USA)
"Oral Microbe-Derived Gluten-Degrading Proteases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Walter Siqueira (University of Western Ontario, Canada)
"The Use of Nanotechnology on Salivary Proteins for the Prevention and Treatment of Oral Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Michael Passineau (Allegheny Health Network, USA)
"Activation of AQP1 in a Human Cell Line Targeted Epigenetic Editing"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Sarah Pringle (University of Groningen, The Netherlands)
"Exhaustion of Salivary Gland Stem Cells Causes Hyposalivation in Primary Sjögren's Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Functions in Exocrine Glands
Discussion Leaders: Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA) and Brij Singh (University of North Dakota, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Roberto Weigert (National Cancer Institute, NIH, USA)
"Molecular Mechanisms of Membrane Remodeling During Regulated Exocytosis in Live Animals"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Sarah Hamm-Alvarez (Keck School of Medicine, University of Southern California, USA)
"Influence of Rab Proteins on Protein Secretion Profiles in Lacrimal Gland"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
David Yule (University of Rochester, USA)
"Ca2+ Signaling Through Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, USA)
"Fix
the Duct, Fix the Acini: CFTR and Sjögren's Syndrome"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understanding the Etiology of Autoimmune
Disease: From Mice to Humans
Discussion Leaders: Ammon Peck (University of Florida, USA) and Julian Ambrus (School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Markus Hardt (Forsyth Institute, USA)
"Proteolytic Profiles Associated with Sjögren's Syndrome"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Rachel Ettinger (MedImmune, USA)
"Sjögren's Syndrome Arises Due to Early-Life Immune Dysregulation"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: A. Darise Farris (Oklahoma Medical Research Foundation, USA)
"From Salivary Gland Lymphocyte Receptors to Salivary Gland Antigen Identification in Sjögren's Syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: David Ann (Beckman Research Institute, City of Hope, USA)
"Autophagy Provides Asparagine to Promote Oncogenic KRAS-Driven Salivary Gland Progression"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Umesh Deshmukh (Oklahoma Medical Research Foundation, USA)
"Microbes, Innate Immunity and the Salivary Gland"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jay Chiorini (National Institute of Dental and Craniofacial Research, NIH, USA)
"The Role of Epigenetics in Salivary Gland Dysfunction"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jill Kramer (State University of New York at Buffalo, USA)
"MyD88 Deficiency Mitigates the Severity of Primary Sjögren's Syndrome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Cuong Nguyen (University of Florida, USA)
"Single-Cell Microengraving Analysis Reveals a Restricted and Sexual Dimorphic T Cell Receptor Repertoire of Interferon-γ and Interleukin-17A Producing T Cells in the Salivary Gland of Sjögren's Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Targeting Inflammation to Retard Disease Pathogenesis
Discussion Leaders: Maria Kukuruzinska (Boston University, USA) and David Ann (Beckman Research Institute, City of Hope, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Marco Colonna (Washington University School of Medicine, USA)
"The Role of TGFβ
in the Development and Function of Salivary Gland Innate Lymphoid Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Yuka Kanno (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Lymphocyte Genes, Genomes and New Drugs"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Helen Braley-Mullen (University of Missouri, USA)
"NOD.H-2h4 Mouse Mutants Provide Robust Models for Defining Mechanisms and Targeting Inflammation in Sjögren's Syndrome"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Kirsten Limesand (University of Arizona, USA)
"Signaling Mechanisms Involved in Radiation-Induced Chronic Loss of Function"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms
of Exocrine Gland Repair and Regeneration
Discussion Leaders: Isabelle Lombaert (University of Michigan, USA) and Rob Coppes (University Medical Center Groningen, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Matthias Hebrok (University of California, San Francisco, USA)
"Dedifferentiation and Transformation of Pancreatic Exocrine Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Stephen Konieczny (Purdue University, USA)
"Clearing the MIST: Deciphering New Transcriptional Networks that Govern Secretory Throughput and the Unfolded Protein Response"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Kimberly Jasmer-McDonald (University of Missouri, USA)
"Exploring the Role of P2Y2 Nucleotide Receptors in a Novel Autoimmune Mouse Model of Sjögren's Syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Pei-Lun Weng (University of Rochester Medical Center, USA)
"Lineage Tracing of Keratin 5 and Axin 2-Positive Cells in Adult Salivary Gland Shows No Contribution to Acinar Cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jason Mills (Washington University School of Medicine in St. Louis, USA)
"How Cells Scale Their Secretory Apparatus in Homeostasis and Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jonathan Axelrod (Hadassah Medical Center, Hebrew University of Jerusalem, Israel)
"Senescence-Mediated Loss of Salivary Gland Function: Is It the End of the Road?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Sten Wie (University of Colorado Anschutz Medical Campus, USA)
"Inhibition of PKC Delta Confers Radioprotection to the Salivary Gland"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Danielle Wu (Rice University, USA)
"Differentiation of Salivary Human Stem/Progenitor Cell Pedigrees in Bioactive 3D Hydrogels"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Clinical Trials for Sjögren's Syndrome
Discussion Leaders: Sarah Knox (University of California, San Francisco, USA) and David Wong (UCLA School of Dentistry, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:30 pm
Robert Fox (Scripps Memorial Hospital and Research Foundation, USA)
"Management of Sjögren's Syndrome: Where Do We Go from Here?"
8:30 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure