Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Aging and Glycobiology: New Frontiers in Exocrine Biology
Discussion Leaders: Sarah Knox (University of California, San Francisco, USA) and Stefan Ruhl (University at Buffalo, SUNY, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Pascal Gagneux (University of California, San Diego, USA)
"Evolution of the 'Molecular Frontier', the Sialome of the Sialome"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Vera Gorbunova (University of Rochester, USA)
"Longevity Mechanisms: Lessons from the Naked Mole Rat and Other Long-Lived Mammals"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Exocrine Gland Development: Cell Plasticity, Fate and Morphology
Discussion Leaders: Elaine Emmerson (The University of Edinburgh, United Kingdom) and Abigail Tucker (King's College London, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Matthew Hoffman (National Institutes of Health, USA)
"Submandibular Gland Development: Insights from Single Cell Transcriptomic Analysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Catherine Lu (New York University, USA)
"From Discovery of Sweat Gland Stem Cells to Future Sweat Gland Regeneration"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Helen Makarenkova (The Scripps Research Institute, USA)
"Fgf10/Fgfr2b Signaling Plays Distinct Roles in Submandibular Gland Morphogenesis, Homeostasis and Repair"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Selected from Poster Abstracts: Alison May (University of California, San Francisco, USA)
"CFTR Acts as an Essential Regulator of Exocrine Gland Morphogenesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Isabelle Lombaert (University of Michigan, USA)
"Molecular Influences During Cell Fate Changes Towards Secretory Units"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Selected from Poster Abstracts: Takanori Narita (College of Bioresource Sciences, Nihon University, Japan)
"Irradiation Acutely Suppresses Intracellular Ca2+ Signaling in Mice Submandibular Gland"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Azmeer Sharipol (University of Rochester, USA)
"Acinar-to-Ductal Metaplasia in Salivary Gland Acinar Cells upon Stress or Injury"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Olga Baker (University of Utah School of Dentistry, USA) and Isabelle Lombaert (University of Michigan, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Engineering the Glandular Epithelium
Discussion Leaders: Melinda Larsen (University at Albany, SUNY, USA) and Natalie Porat-Shliom (Center for Cancer Research, National Cancer Institute, NIH, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Ophir Klein (University of California, San Francisco, USA)
"Lineage Hierarchies and Plasticity in Epithelial Stem Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Deborah Andrew (Johns Hopkins University School of Medicine, USA)
"Creating 3D Tubes from 2D Primordia: The Role of Fkh (Drosophila FoxA) and Its Downstream Targets"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Julie Sneddon (University of California, San Francisco, USA)
"Engineering the Endocrine Pancreas"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Zev Gartner (University of California, San Francisco, USA)
"The Physical and Chemical Contributions to the Self-Organization (and Disorganization) of the Human Mammary Gland"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regenerating a Secretory Organ: Current Models and Outcomes
Discussion Leaders: Danielle Benoit (University of Rochester, USA) and Michael Passineau (Allegheny Health Network, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Catherine Ovitt (University of Rochester, USA)
"Potential of Endogenous Cells in Salivary Gland Regenerative Strategies"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Rob Coppes (University Medical Center Groningen, The Netherlands)
"Regeneration of Secretory Glands After Cancer Therapy: Towards Clinical Application?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Trisiani Affandi (University of Colorado Anschutz Medical Campus, USA)
"PKCd Regulates Chromatin Conformation and DNA Double Stranded Break Repair in Response to Irradiation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Lizi Wu (University of Florida, USA)
"Probing the Role of the CRTC1-MAML2 Fusion Oncogene-Induced lncRNA LINC00473 in Human Mucoepidermoid Carcinoma"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Darlene Dartt (Schepens Eye Research Institute / Massachusetts Eye and Ear, Harvard Medical School, USA)
"Regenerating the Lacrimal Gland: Current Progress and Future Challenges"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
John Engelhardt (University of Iowa, USA)
"Wnt/TCF Control of Glandular Myoepithelial Stem Cell Regenerative Responses in the Airway"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Kihoon Nam (University of Utah School of Dentistry, USA)
"Regeneration of Salivary Glands In Vivo Using Double Layer Cell Sheets"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Current Concepts in Salivary Cancer: From Etiology to Treatments
Discussion Leaders: Mary Reyland (University of Colorado Denver, USA) and Bob Varelas (Boston University School of Medicine, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Patrick Ha (University of California, San Francisco, USA)
"Myb-NFIB Interactions in Adenoid Cystic Carcinoma"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Antonio Amelio (University of North Carolina at Chapel Hill, USA)
"Mucoepidermoid Carcinoma: CRTCal Links Between CREB and MYC Signaling"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Nisha D'Silva (University of Michigan, USA)
"Perineural Invasion in Cancer: A Dynamic Process"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Jacques Nor (University of Michigan School of Dentistry, USA)
"Therapeutic Targeting of Salivary Gland Cancer Stem Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucins and Salivary Proteins
Discussion Leaders: Ilene Gipson (Schepens Eye Research Institute, Harvard University, USA) and Arjan Vissink (University Medical Center Groningen, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Omer Gokcumen (University at Buffalo, SUNY, USA)
"Amylase Copy Number Analysis in Several Mammalian Lineages Reveals Convergent Adaptive Bursts Shaped by Diet"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Selected from Poster Abstracts: Walter Siqueira (University of Western Ontario, Canada)
"Salivary Proteome of Individuals with Moebius Syndrome"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Preethi Chander (National Institute of Dental and Craniofacial Research, NIH, USA)
"Human Salivary Proteome Wiki"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Markus Hardt (Forsyth Institute, USA)
"Mapping Quantitative Differences in Human Salivary Gland Secretions by Dried Saliva Spot Sampling and NanoLC-MS/MS"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Katharina Ribbeck (Massachusetts Institute of Technology, USA)
"Influence of Salivary Mucins on Oral Streptococci Physiology"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Ann-Marie Torregrossa (University at Buffalo, USA)
"A Role for Salivary Proteins in Taste and Feeding"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Gabriella Peluso (National Institute of Dental and Craniofacial Research, NIH, USA)
"Loss of Galnt3 Results in Altered Glycosylation of the Major SMG Mucin Muc10"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Membrane Dynamics: Signaling and Function
Discussion Leaders: Sarah Hamm-Alvarez (University of Southern California, USA) and Roberto Weigert (National Cancer Institute, NIH, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, USA)
"Functional Relevance of STIM Proteins: Tuning Store-Operated Ca2+ Entry and More"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Gary Weisman (University of Missouri, USA)
"P2 Nucleotide Receptor Structure and Salivary Gland Function in Sjögren's Syndrome"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Emily Bates (University of Colorado Anschutz Medical Campus, USA)
"Ion Channel Control of Dynamic Release of BMP"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
James Sneyd (University of Auckland, New Zealand)
"Modeling Saliva Secretion in Three Dimensions: How Much Detail Do You Really Need?"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Autoimmune Disease and Aging: Models and Outcomes
Discussion Leaders: Jill Kramer (University at Buffalo, SUNY, USA) and Maria Kukuruzinska (Boston University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Lindsey Criswell (University of California, San Francisco, USA)
"Genetic Studies of Sjogren's Syndrome Highlight Disease Heterogeneity According to Ancestry and Phenotypic Features"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Cintia de Paiva (Baylor College of Medicine, USA)
"Interplay of Antigen Presenting Cells and Aging and the Development of Dry Eye"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Junichi Iwata (The University of Texas Health Science Center at Houston, USA)
"Excessive Cholesterol Synthesis Causes Sjögren's Syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Akiko Shitara (Asahi University, Japan)
"Cdc42 Negatively Regulates Endocytosis During Apical Membrane Maintenance in Live Animals"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Brij Singh (University of Texas Health Science Center at San Antonio, USA)
"Genomic Characterization of Sjogren's Syndrome"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Achim Werner (National Institute of Dental and Craniofacial Research, NIH, USA)
"Dissecting Ubiquitin-Dependent Stem Cell-Fate Decisions During Human Development and Disease"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: Stefan Feske (New York University School of Medicine, USA)
"Calcium Signaling via CRAC Channels in the Pathogenesis of Sjögren's Syndrome"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Metabolic Regulation and Adaptation
Discussion Leaders: Jay Chiorini (National Institute of Dental and Craniofacial Research, NIH, USA) and Olga Baker (University of Utah School of Dentistry, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:40 pm
Shingo Kajimura (University of California, San Francisco, USA)
"Metabolic Adaptation in Physiology and Disease"
8:40 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure