| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell Compartmentalization and G Protein Signaling |
| Discussion Leader: Morris Birnbaum (University of Pennsylvania) |
| 7:30 pm - 8:10 pm | Jeffrey Benovic (Jefferson University)
"Scaffolding proteins in GPCR signaling" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 9:10 pm | Mark Von Zastrow (UCSF)
"Regulation of GPCR signaling by membrane trafficking" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | TOR and the Regulation of Cell Growth |
| Discussion Leader: John Blenis (Harvard Medical School) |
| 9:00 am - 9:25 am | Mike Hall (University of Basel)
"TOR and cell growth" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Pierre Leopold (Université de Nice)
"TOR, IGF/PI3K, nutrition and the control of growth in Drosophila" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | David Sabatini (MIT)
"Growth control by the mTOR pathway" |
| 11:05 am - 11:30 am | Kun-Liang Guan (University of Michigan)
"Cell growth regulation, mTOR, cell size control" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Richard Roth (Stanford University)
"Downstream of Akt: PRAS40 and mTOR" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Diane Fingar (University of Michigan)
"Control of cell cycle progression by mTOR" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Approaches to Signal Transduction |
| Discussion Leader: Mark Lemmon (University of Pennsylvania) |
| 7:30 pm - 7:55 pm | Laura Kiessling (University of Wisconsin)
"Chemotaxis in bacteria and neutrophils" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Stanislav Schvartsman (Princeton University)
"Computational analysis of EGF receptor signaling in developing tissues" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Mark Phillips (New York University)
"Compartmentalized Signaling of Ras" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jonathan Backer (Albert Einstein College of Medicine)
"Molecular interactions in Class I PI3K" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Phosphatases |
| Discussion Leader: Ben Neel (Harvard Medical School) |
| 9:00 am - 9:25 am | Jack Dixon (UCSD)
"Lipid phosphatases and signaling" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Helen Piwnica-Worms (Washington University)
"Cdc25 family of Protein Phosphatases in Cell Cycle- and Checkpoint-Control" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Bruce Gelb (Mount Sinai School of Medicine)
"PTPN11 Mutations in Noonan Syndrome and Related Disorders" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Ilaria Rebay (Whitehead Institute)
"Protein tyrosine phosphatase function of the eyes absent transcription factor" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Nick Tonks (Cold Spring Harbor Laboratory)
"Protein tyrosine phosphatases" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Inositol Phospholipids |
| Discussion Leader: Morris White (Harvard Medical School) |
| 7:30 pm - 7:55 pm | Lew Cantley (Harvard Medical School)
"phosphoinositide kinase signaling in cellular regulation" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Mark Lemmon (University of Pennsylvania)
"Lipid binding domains" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Dario Alessi (University of Dundee)
"Phosphoinositide-dependent kinase 1" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Katja Bjorklof (University of Fribourg)
"Novel pathways for activation of PI3K gamma" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling Molecules and Human Disease |
| Discussion Leader: Jeffrey Benovic (Jefferson University) |
| 9:00 am - 9:25 am | Charles Sawyer (UCLA)
"Kinase Pathways and Inhibitors" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Ben Neel (Harvard Medical School)
"Tyrosine phosphatases in health and disease" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:05 am | Peter Houghton (St. Jude's Hospital)
"mTOR signaling in cancer: potential as a therapeutic target" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Nathalie Ahn (University of Colorado)
"Proteomic analysis of signal transduction in melanoma" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:05 pm | Reuben Shaw (Harvard Medical School)
"Lkb1" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Francisca Vazquez (Johns Hopkins Medical School)
"PTEN regulation in amoebae :a model for signal transduction" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 3 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MAP kinase pathways |
| Discussion Leader: Tom Sturgill (University of Virginia) |
| 7:30 pm - 7:55 pm | Beverly Errede (University of North Carolina)
"MAPK pathways in yeast"" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Gary Johnson (University of North Carolina)
"MAPK pathways |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | John Blenis (Harvard Medical School)
"DEF domains and molecular sensors for differential regulation of MAPK/RSK signaling" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Tom Sturgill (University of Virginia)
"Intestinal cell kinase" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling to Metabolic Outputs |
| Discussion Leader: Richard Roth (Stanford University) |
| 9:00 am - 9:25 am | Morris White (Harvard Medical School)
"The regulation of IRS-protein signaling in growth and metabolism" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Mike Czech (University of Massachusetts)
"The insulin signaling pathway" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Gus Lienhard (Dartmouth)
"GAPs and insulin action" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Marc Montminy (UCSD)
"cAMP and calcium dependent signaling in islet cells" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Peter Roach (Indiana University)
"Glycogen Synthase" |
| 12:05 pm - 12:15 pm | Jared Rutter (University of Utah)
"PAS kinase and the fate of intracellular glucose" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 4 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Recognition |
| Discussion Leader: Mark von Zastrow (UCSF) |
| 7:30 pm - 7:55 pm | Susan Taylor (UCSD)
"PKA: Molecular Recognition and Dynamics" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Michael Yaffe (MIT)
"Phosphopeptide binding domains and cell cycle regulation" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Sharon Campbell (University of North Carolina)
"Focal adhesion targeting domain of Focal Adhesion kinase" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Elaine Elion (Harvard Medical School)
"Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
