| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GPCR Signaling |
| Session chair: Michel Bouvier (Université de Montréal, Montréal, Canada) |
| 7:30 pm - 7:55 pm | Michel Bouvier (Université de Montréal, Montréal, Canada)
"Phosphorylation-dependent and -independent regulation of the GABAß receptor signalling efficacy" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Steven Ferguson (Robarts Research Institute, London, Ontario)
"Regulation of metabotropic glutamate receptor signaling by optineurin and mutant huntingtin" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Randy Hall (Emory University School of Medicine, Atlanta, GA)
"Control of GPCR Signaling by PDZ Scaffolds" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Eric Prossnitz (University of New Mexico, Albuquerque, NM)
"GPCRs and Steroids: An odd couple?" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Welcome Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Regulation of GPCR/G Protein Signaling |
| Session chair: Martin Lohse (University of Wuerzburg, Wuerzburg, Germany) |
| 9:00 am - 9:25 am | Martin Lohse (University of Wuerzburg, Wuerzburg, Germany)
"Kinetic analysis of ligand binding and GPCR signaling with fluorescent methods" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Heidi Hamm (Vanderbilt University Medical Center, Nashville, TN)
"How do receptors activate G proteins?" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Aylin Hanyaloglu (UC San Francisco, CA)
"Role of Hrs in GPCR recycling and resensitization" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Louis Luttrell (Medical University of South Carolina, Charleston, SC)
"Spatial and temporal organization of MAP kinase signaling" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | JoAnn Trejo (University of North Carolina, Chapel Hill, NC)
"Protease-activated Receptors: New insights into regulation of GPCR signaling and trafficking" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Marc Caron (Duke University Medical Center, Durham, NC)
"GPCR Regulator Mechanisms: In vivo Signaling Paradigms" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipid Signaling |
| Session chair: Patrick Casey (Duke University Medical Center, Durham, NC) |
| 7:30 pm - 7:55 pm | Patrick Casey (Duke University Medical Center, Durham, NC)
"Mechanisms and Consequences of Protein Prenylation" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Maurine Linder (Washington University School of Medicine, St. Louis, MO)
"DHHC-Cysteine Rich Domain Proteins: A Family of Protein Acyltransferases" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Marc Lemmon (University of Pennsylvania, Philadelphia, PA)
"PH domains and phosphoinositides" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Shawn Milano (Thomas Jefferson University, Philadelphia, PA)
"Regulation of arrestin function by phosphoinositides" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Heterotrimeric G Protein Regulation |
| Session chair: Kendall Blumer (Washington University School of Medicine, St. Louis, MO) |
| 9:00 am - 9:25 am | Kendall Blumer (Washington University School of Medicine, St. Louis, MO)
"RGS protein function and regulation in the cardiovascular and central nervous systems" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | David Siderovski (University of North Carolina, Chapel Hill, NC)
"Regulators of the G-protein alpha subunit nucleotide cycle" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Vladlen Slepak (University of Miami School of Medicine, Miami, FL)
"Mechanism of light-induced translocation of photoreceptor G protein and arrestin" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Steve Lanier (LSUHSC, New Orleans, LA)
"Receptor-independent activators of G-protein signaling" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Michael Koelle (Yale University School of Medicine, New Haven, CT)
"Genetic analysis of G protein signaling in C. elegans" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Henrik Dohlman (University of North Carolina, Chapel Hill, NC)
"Regulation of yeast G protein and MAPK signaling fidelity by ubiquitination" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sensory Signaling |
| Session leader: Randall Reed (Johns Hopkins University, Baltimore, MD) |
| 7:30 pm - 7:55 pm | Randall Reed (Johns Hopkins University, Baltimore, MD)
"Constructing Olfaction: Genes and Proteins Contributing to Sensory Function" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Hiroaki Matsunami (Duke University Medical Center, Durham, NC)
"Odorant receptor expression in heterologous cells" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | James Hurley (University of Washington, Seattle, WA)
"Recoverin, synaptic transmission and visual sensitivity" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jean-Martin Beaulieu (Duke University Medical Center, Durham, NC)
"A beta-arrestin/Akt/PP2A signaling complex mediates dopaminergic neurotransmission and behavior" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structural Insight into Signaling |
| Session leader: John Sondek (University of North Carolina, Chapel Hill, NC) |
| 9:00 am - 9:25 am | John Sondek (University of North Carolina, Chapel Hill, NC)
"Rho GTPases and pleckstrin homology domains: consorting membranes" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Brian Kobilka (Stanford University, Stanford, CA)
"Conformational dynamics of the beta 2 adrenoceptor: the effect of ligand structure on receptor structure" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:25 am | Krzysztof Palczewski (University of Washington School of Medicine, Seattle, WA)
"Rhodopsin organization in detergent, crystal and membranes" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | John Tesmer (University of Texas at Austin, Austin, TX)
"Structural Studies of G Protein-Coupled Receptor Kinases and their Complexes with Heterotrimeric G Proteins" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Steven Sprang (UT Southwestern Medical Center, Dallas, TX)
"Structural investigations of G alpha function" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Rama Ranganathan (UT Southwestern Medical Center, Dallas, TX)
"Evolutionary Rules for Specifying Protein Folding and Function" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE EVENING |
| 7:30 pm - 7:35 pm | Jeffrey Benovic (Thomas Jefferson University, Philadelphia, PA)
Introduction |
| 7:35 pm - 8:20 pm | Robert Lefkowitz (Duke University Medical Center, Durham, NC)
"Transduction of Receptor Signals by ß-arrestins and GRKs" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:35 pm | Mark von Zastrow (University of California San Francisco, San Francisco, CA)
Introduction |
| 8:35 pm - 9:20 pm | Charles Zuker (UCSD School of Medicine, La Jolla, CA)
"The Biology of Mammalian Taste" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling Integration/Networks |
| Session chair: Natalie Ahn (University of Colorado at Boulder, Boulder, CO) |
| 9:00 am - 9:25 am | Natalie Ahn (University of Colorado at Boulder, Boulder, CO)
"Proteomics and signal transduction" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Beverly Errede (University of North Carolina, Chapel Hill, NC)
"Distinct MAPK-mediated responses arise from alternate routes through signaling circuitry" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Andrejs Kreumins (UT Southwestern Dallas, TX)
"Dissection of Heterotrimeric G Protein Pathways: Evidence for Networks" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Ravi Iyengar (Mount Sinai School of Medicine, New York, NY)
"Regulatory motifs in mammalian cellular networks" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Alex Brown (Vanderbilt University School of Medicine, Nashville, TN)
"Lipidomics and Network Modeling in the Alliance for Cellular Signaling" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Peter Mombaerts (The Rockefeller University, New York, NY)
"Olfaction targeted" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Nuclear Sensors and Signaling |
| Session chair: Richard Fishel (Ohio State University, Columbus, OH) |
| 7:30 pm - 7:50 pm | Richard Fishel (Ohio State University, Columbus, OH)
"MSH/MLH Lesion Sensors and Signaling: not just mismatch repair" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | David Toczyski (University of California San Francisco, San Francisco, CA)
"Recognition and signalling of DNA damage by the DNA damage checkpoint" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Helle Ulrich (Karl-von-Frisch-Strasse, Marburg, Germany)
"Ubiquitin and SUMO - signals for DNA damage tolerance" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Susan Lovett (Brandeis University, Waltham, MA)
"G-proteins, replication fork arrest and cell cycle in bacteria" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
