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1. Sensory Motifs (Sunday evening, 7:30 PM - 10:30 PM)
Welcome & Orientation:
Steven Block, Chair (10 min)
Philip Matsumura, Vice Chair
Carlyle Storm, GRC Director
SessionChair: Katherine Borkovich
Mini-talkChair: Richard Stewart
Speakers:
Katherine Borkovich
"Heterotrimeric G proteins in Neurospora crassa: Regulators of differentiation, cAMP metabolism and more" (Introduction and talk, 20 min)
Discussion of Borkovich talk (10 min)
Thomas Silhavy
"The response regulator SprE (RssB): A hungry orphan" (20 min)
Discussion of Silhavy talk (10 min)
Break (20 min)
Gunther Gerisch
"Outside-in, inside-out, and inside-in signaling" (20 min)
Discussion of Gerisch talk (10 min)
Stephan Schuster
"How to sustain the big crunch: Osmotic stress response in Dictyostelium" (20min)
Discussion of Schuster talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time.- 3 hr
2. Bacterial Receptors (Monday morning, 9:00 AM - 12:30 PM)
Session Chair: Michael Manson
Mini-talkChair: Jeffry Stock
Speakers:
Michael Manson
"A receptor by any other name does not smell the same" (Introduction and talk, 20 min)
Discussion of Manson talk (10 min)
J. Sandy Parkinson
"Control of CheA kinase activity by receptor signaling complexes" (20 min)
Discussion of Parkinson talk (10 min)
Barry Taylor
"The role of a PAS domain in sensing oxygen and redox" (20 min)
Discussion of Taylor talk (10 min)
Break (20 min)
Gerald Hazelbauer
"Features of the transmembrane and cytoplasmic domains of chemoreceptors" (20 min)
Discussion of Hazelbauer talk (10 min)
Joseph Falke
"The aspartate receptor: New insights regarding kinase regulation" (20 min)
Discussion of Falke talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr 20 min
12:30 PM - ATTEND GRC PHOTO SHOOT BEFORE GOING TO LUNCH (-10 min)
3. Structure/Function in Chemotaxis (Monday evening, 7:30 PM - 10:30 PM)
SessionChair: Philip Matsumura
Mini-talk Chair: LynmarieThompson
Speakers:
Philip Matsumura (Introduction, 5 min)
Frederick Dahlquist
"CheY- Before, during and after phosphorylation" (20 min)
Discussion of Dahlquist talk (10min)
Yih-Ling Tzeng
"Molecular recognition between response regulator andphosphotransferase" (10 min)
Discussion of Tzeng talk (5 min)
Robert Gunsalus
"Structure of the NarL response regulator" (10 min)
Discussion of Gunsalus talk (5 min)
Ann Stock
"Structural analysis of chemoreceptor modification enzymes" (20 min)
Discussion of Stock talk (10 min)
Break (30 min)
Robert Weis
"Receptor-transferase interactions and subunit interactions during methylation" (20 min)
Discussion of Weis talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr
4. Signaling Diversity I (Tuesday morning, 9:00 AM - 12:30 PM)
Session Chair: George Ordal
Mini-talkChair: John Spudich
Speakers:
George Ordal (Introduction, 5 min)
Dieter Osterhelt
"A link between bioenergetics and signal transduction: The cytoplasmic chemoreceptorfor arginine in the archaeon Halobacterium salinarum" (20 min)
Discussion of Oesterhelt talk (10 min)
Maqsudal Alarn
"The Halobacterial transducerfamily: An example of how a common C-terminal signaling motif coupled to varied N-terminal domains is exploitedfor diverse functions of chemo-, aero-, osmo-, andphototaxis" (20 min)
Discussion of Alam talk (10 min)
Break (40 min)
Judith Armitage
"Multiple chemosensory pathways in Rhodobacter sphaeroides and environmental control of their expression" (20 min)
Discussion of Armitage talk (10 min)
Michael Eisenbach
"Regulation of CheY-switch interaction in bacterial chemotaxis" (20 min)
Discussion of Eisenbach talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr 15 min
5. G Protein-linked Signaling (Tuesday evening, 7:30 PM - 10:30 PM)
EveningLecture: Melvin Simon
G Proteins & Signaling Pathways" (50 min)
Discussion of Simon talk (10 min)
Break (20 min)
Session: G Protein Signaling & Late-breaking News
SessionChair: Peter Devreotes
Mini-talk Chair: Daniel Koshland, Jr.
Speakers:
Peter Devreotes
"Gprotein-linked signaling in Dictyostelium" (Introduction and talk, 20 min)
Discussion of Devreotes talk (10 min)
Adam Kuspa
"Starvation sensing in Dictyostelium" (20 min)
Discussion of Devreotes talk (10 min)
Mini-talks on Late-breaking News (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 2 hr 50 min
6. Signaling Diversity II (Wednesday morning, 9:00 AM - 12:30 PM)
SessionChair: Joseph Lengeler
Mini-talkchair: RasikaHarshey
Speakers:
Joseph Lengeler
"The bacterial PTS: A prokaryotic signal transduction system with the logic and complex eukaryotic system" (Introduction and talk, 20 min)
Discussion of Lengeler talk (10 min)
Bonnie Bassler
"Quorum sensing in marine Vibrio" (20 min)
Discussion of Bassler talk (10 min)
Break (40 min)
David Zusman
"Frz interacting proteins requiredfor developmental signaling in Myxococcus xanthus" (20 min)
Discussion of Zusman talk (10 min)
Patricia Hartzell
"GTPases and chaperones: Oldftiends with new roles in sporulation and motility of Myxococcus xanthus" (20 min)
Discussion of Hadzell talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr 10 min
7. Linear Motors (Wednesday evening, 7:30 PM - 10:30 PM)
SessionChair: James Spudich
Mini-talk Chair: Steven Block
Speakers:
James Spudich (Introduction, 5 min)
Robert Fletterick
"Structure andfunction of the molecular motor kinesin" (20 min)
Discussion offletterick talk (10 min)
Steven Block
"Mechanochemical energy coupling in single kinesin motors" (20 min)
Discussion of Block talk (10 min)
Break (20 min)
James Spudich
"On energy transduction and single myosin molecule mechanics" (20 min)
Discussion of Spudich talk (10 min)
Mini-talks (T.B.A.) (2 x 5 min + 10 min discussion = 20 min)
Total running time: 2 hr 15 min
7'. Party (Wednesday night, 10:00 PM -whenever)
SessionChair: Janine Maddock
Total running time: unknown
8. Rotary Motors (Thursday moming, 9:00 AM - 12:30 PM)
Session Chair: Howard Berg
Mini-talk Chair: Robert Macnab
Speakers:
Howard Berg (Introduction, 5 min)
Kazuhiko Kinosita
"F1 ATPase: A rotary stepper motor made of a single molecule" (20 min)
Discussion of Kinosita talk (10 min)
George Oster
"Protonmotive energy transduction in Fo ATPase" (20 min)
Discussion of Oster talk (10 min)
Break (25 min)
Howard Berg
"CWICCW rotation of theflagellar motor" (20 min)
Discussion of Berg talk (10 min)
David Blair
"Mutational studies of torque-generating components of theflagellar motor" (20 min)
Discussion of Blair talk (10 min)
David DeRosier
"Mixed symmetries within the motor suggest a mechanism" (20 min)
Discussion of DeRosier talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr 30 min
9. Perfumes, Rhythms and Beyond (Thursday evening, 7:30 PM - 10:30 PM)
Session Chair: Susan Golden
Mini-talk Chair: Jeffrey Segall
Speakers:
Susan Golden
"Circadian rhythms ofgene expression in Cyanohacteria" (Introduction and talk, 20 min)
Discussion of Golden talk (10 min)
Robert Bourret
"Activation of Chel" (20 min)
Discussion of Bourret talk (10 min)
Break (30 min)
Richard Firtel
"Regulation of cell movement and signaling in Dictyostelium" (20 min)
Discussion of Firtel talk (10 min)
Alan Kimmel
"Regulation of cellpatterning and axisformation in Diclyostelium" (20 min)
Discussion of Kimmel talk (10 min)
Mini-talks (T.B.A.) (4 x 5 min + 10 min discussion = 30 min)
Total running time: 3 hr
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