| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Ann West |
| 7:40 pm - 9:30 pm | Diversity in Microbial Chemotaxis |
| Discussion Leader: Igor B. Zhulin (University of Tennessee - Oak Ridge National Laboratory, USA) |
| 7:40 pm - 7:45 pm | Igor B. Zhulin (University of Tennessee - Oak Ridge National Laboratory, USA)
"Overview of microbial chemotaxis" |
| 7:45 pm - 8:05 pm | Judith P. Armitage (Oxford University, UK)
"Rewiring the chemosensory pathways of Rhodobacter sphaeroides" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Victor Sourjik (ZMBH, University of Heidelberg, Germany)
"Robustness and evolution of E. coli chemotaxis pathway" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Rebecca Parales (University of California, Davis, USA)
"Bacterial chemotaxis to environmental pollutants" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Peter N. Devereotes (Johns Hopkins University, USA)
"Signal networks for chemotaxis in eukaryotic cells" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Receptor Signaling and Architectural Design |
| Discussion Leader: Barry Taylor (Loma Linda University, USA) |
| 9:00 am - 9:05 am | Barry Taylor (Loma Linda University, USA)
"Overview of receptor signaling and architectural design" |
| 9:05 am - 9:25 am | Grant Jensen (California Institute of Technology, USA)
"Universal architecture of chemoreceptor arrays" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Joseph J. Falke (University of Colorado, USA)
"The chemotaxis signaling array: ultrastability and on-off switching mechanism" |
| 9:50 am - 9:55 am | Discussion |
| 10:00 am - 10:45 am | Group Photo / Coffee Break |
| 10:45 am - 11:05 am | Gerald Hazelbauer (University of Missouri, Columbia, USA)
"Defining functional units for chemoreceptor activities" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | John S. Parkinson (University of Utah, USA)
"How HAMP domains mediate input-output transactions in bacterial signaling" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Christopher Rao (University of Illinois, Urbana, USA)
"The unique but widespread chemotaxis receptors of Bacillus subtilis" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | John Spudich (University of Texas Medical School, Houston, USA)
"Microbial rhodopsins: receptors, channels, and pumps from a single design" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Flagellar Motors and Cell Mechanics |
| Discussion Leader: Shin-Ichi Aizawa (Perfectural University of Hiroshima, Japan) |
| 7:30 pm - 7:35 pm | Shin-Ichi Aizawa (Perfectural University of Hiroshima, Japan)
"Overview of flagellar motors and cells mechanics" |
| 7:35 pm - 7:55 pm | Michio Homma (Nagoya University, Japan)
"Ion flux pathway of stator complex in sodium-driven flagellar motor" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Tohru Minamino (Osaka University, Japan)
"Molecular mechanism of proton-driven bacterial flagellar type III protein export" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Joshua Shaevitz (Princeton University, USA)
"Motor-driven intracellular transport powers A-motility in Myxococcus xanthus" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Minitalk: Ryan Powell (University of Maryland Biotechnology Institute, Baltimore, USA)
"Regulation of motility in a ubiquitous marine bacterium" |
| 9:00 pm - 9:02 pm | Discussion |
| 9:02 pm - 9:12 pm | Minitalk: Gaston Paris (Leloir Institute, Argentina)
"The light-activated signal transduction pathway in Brucella" |
| 9:12 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Minitalk: Kylie Watts (Loma Linda University, USA)
"Aer-2, a model for PAS/HAMP and poly-HAMP signaling mechanisms" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Intracellular Signaling in Bacteria |
| Discussion Leader: Frederick Dahlquist (University of California, Santa Barbara, USA) |
| 9:00 am - 9:05 am | Frederick Dahlquist (University of California, Santa Barbara, USA)
"Overview of intracellular signaling in bacteria" |
| 9:05 am - 9:25 am | Ann Stock (UMDNJ-Robert Wood Johnson Medical School, USA)
"Regulating response regulators" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ruth Silversmith (University of North Carolina, USA)
"Structure of the Borrelia burgdorferi CheX/CheY3 complex" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:15 am | Michael Laub (Massachusetts Institute of Technology, USA)
"Specificity and evolution of two-component signaling pathways" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Mark Goulian (University of Pennsylvania, USA)
"Feedback regulation in the PhoQ/PhoP two-component system" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Linda McCarter (University of Iowa, USA)
"Surface specific gene expression" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Urs Jenal (University of Basel, Switzerland)
"Coordination of Caulobacter cresentus cell cycle and pole morphogenesis" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm | Minitalk: Kirsten Jung (Ludwig Maximilians Universität München, Germany)
"Population heterogeneity in the quorum sensing response of Vibrio harveyi" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:25 pm | Minitalk: Marc Erhardt (University of Utah, USA)
"The C-ring functions as an affinity cup-like structure in flagellar type III secretion" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Motility Apparati and Regulation |
| Discussion Leader: Nyles Charon (West Virginia University, USA) |
| 7:30 pm - 7:35 pm | Nyles Charon (West Virginia University, USA)
"Overview of motility apparati and regulation" |
| 7:35 pm - 7:55 pm | Jun Liu (University of Texas Medical School, Houston, USA)
"Molecular architecture of spirochetal flagellar motor in situ" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | David Blair (University of Utah, USA)
"Organization and mechanism of the flagellar switch" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Brian R. Crane (Cornell University, USA)
"Structural studies of flagellar switch complex" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Rasika Harshey (University of Texas, Austin, USA)
"The cyclic-di-GMP receptor protein YcgR localizes to the flagellar basal body and inhibits chemotaxis in Salmonella" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Minitalk: Nicolas Delalez (Oxford University, UK)
"Signal-dependent turnover of the bacterial flagellar switch protein FliM" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Intracellular Signaling in Eukaryotic Microorganisms |
| Discussion Leader: Jan Fassler (University of Iowa, USA) |
| 9:00 am - 9:05 am | Jan Fassler (University of Iowa, USA)
"Overview of intracellular signaling in eukaryotic microorganisms" |
| 9:05 am - 9:25 am | Haruo Saito (University of Tokyo, Japan)
"Osmosensory signal transduction in the budding yeast" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Richard Calderone (Georgetown University Medical Center, USA)
"Histidine kinases, cell wall biosynthesis, and relationships to Candida albicans and candidiasis" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:15 am | Kaz Shiozaki (University of California, Davis, USA)
"Stress sensing and response in fission yeast S. pombe" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Katherine A. Borkovich (University of California, Riverside, USA)
"Two-component systems in Neurospora" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | William F. Loomis (University of California, San Diego, USA)
"Extrinsic and intrinsic noise limits in eukaryotic chemotaxis" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Alan R. Kimmel (National Institutes of Health-LCDB/NIDDK, USA)
"Ectodomain shedding and presenilin processing of membrane proteins regulates phagocytosis and cell fate specification in Dictyostelium" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm | Minitalk: Matthew Neiditch (UMDNJ-New Jersey Medical School, USA)
"Structural biology of multifunctional bacterial phosphatases" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:25 pm | Minitalk: Ann McEvoy (University of California, Berkeley, USA)
"Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution optical microscopy" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Motility and Spatial Organization |
| Discussion Leader: Janine Maddock (University of Michigan, USA) |
| 7:30 pm - 7:35 pm | Janine Maddock (University of Michigan, USA)
"Overview of motility and spatial organization" |
| 7:35 pm - 7:55 pm | Zemer Gitai (Princeton University, USA)
"Novel bacterial cytoskeletal proteins and regulators" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Chris Janetopoulos (Vanderbilt University, USA)
"Gradient detection and motility in the social amoeba" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Lotte Søgaard-Andersen (Max Planck Institute for Terrestrial Microbiology, Germany)
"Establishing and maintaining cell polarity in M. xanthus" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Tâm Mignot (Institut de Microbiologie de la Méditerrannée, France)
"Dissecting a novel motility machinery in bacteria" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Minitalk: Richard Berry (University of Oxford, UK)
"Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Intercellular Communication |
| Discussion Leader: John R. Kirby (University of Iowa, USA) |
| 9:00 am - 9:05 am | John R. Kirby (University of Iowa, USA)
"Overview of intercellular communication" |
| 9:05 am - 9:25 am | E. Peter Greenberg (University of Washington, USA)
"What's new with quorum sensing" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Karen L. Visick (Loyola University, USA)
"The regulatory network controlling biofilm formation and colonization by Vibrio fischeri" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:15 am | Fitnat Yildiz (University of California, Santa Cruz, USA)
"Regulation of biofilm formation in Vibrio cholerae" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:10 am | Thierry Emonet (Yale University, USA)
"Enzyme-substrate localization affects signaling in bacterial chemotaxis" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Daniel B. Kearns (Indiana University, USA)
"Bistable expression of motility genes in Bacillus subtilis" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | David R. Zusman (University of California, Berkeley, USA)
"Coupling the FrzCD receptor to the A-motility motors" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:05 pm - 12:15 pm | Minitalk: Karine Gibbs (Harvard University, USA)
"Self-identity gene expression in the bacterium Proteus mirabilis" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:25 pm | Minitalk: Ganhui Lan (IBM TJ Watson Research Center, USA)
"Adapt locally and act globally: chemo-receptor's strategy in maintaining high sensitivity in environment with mixed signals" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Pathogenesis and Virulence Mechanisms |
| Discussion Leader: Linda Kenney (University of Illinois, Chicago, USA) |
| 7:30 pm - 7:35 pm | Linda Kenney (University of Illinois, Chicago, USA)
"Overview of pathogenesis and virulence mechanisms" |
| 7:35 pm - 7:55 pm | Eduardo A. Groisman (Washington University, Saint Louis, USA)
"Controlling the activity of two-component regulatory systems" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Vanessa Sperandio (University of Texas Southwestern Medical Center, USA)
"Inter-kingdom chemical signaling in bacterial pathogenesis" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Lori L. Burrows (McMaster University, Canada)
"Type IV pili: weapons of mass retraction" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:10 pm | Liz Sockett (University of Nottingham, UK)
"When is a predator not a predator? Prey dependent versus axenic growth in Bdellovibrio" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:20 pm | Minitalk: Jason Tuckerman (University of Texas Southwestern Medical Center, USA)
"Oxygen control of RNA degradosomes via c-di-GMP" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | Closing Announcements |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
