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Signal Transduction by Engineered Extracellular Matrices (GRS)

Gordon Research Seminar

Studying and Directing Cellular Function Through Natural and Engineered Microenvironment

July 5 - 6, 2014
Chairs Brandon L. Blakely and Jorge Valdez

Conference Description

The Gordon Research Seminar on Signal Transduction by Engineered Extracellular Matrices is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The aim of this GRS is to provide a forum for junior scientists to present and discuss their work regarding the study or manipulation of cellular behavior in response to their extracellular surroundings. The focus of this conference ranges from biology to engineering and includes applications such as materials development, mechanotransduction, cellular force and remodeling reporting, and tissue development.

Related Meeting

This GRS will be held in conjunction with the "Signal Transduction by Engineered Extracellular Matrices" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmEngineered-ECM Cues for Stem Cell Differentiation and Survival
Discussion Leaders: Jason Burdick (University of Pennsylvania) and Brandon Blakely (National Institute of Standards and Technology)
3:45 pm - 4:00 pm Simone Allazetta (École Polytechnique Fédérale de Lausanne)
"Biomechanical and Biochemical Modulation of Cellular Microniches Using Droplet-Based Microfluidics"
4:00 pm - 4:07 pm Discussion
4:07 pm - 4:22 pm Chun Yang (University of Colorado Boulder)
"YAP Mediates Extracellular Mechanotransduction in Human Mesenchymal Stem Cells in 3D Thiol-ene Hydrogels"
4:22 pm - 4:30 pm Discussion
4:30 pm - 6:00 pmPoster Session I (Last Names Beginning A-M)
6:00 pmDinner
7:30 pm - 9:30 pmFrom Tissue Form to Cell Function
Discussion Leaders: Linda Griffith (Massachusetts Institute of Technology) and Julianne Holloway (University of Pennsylvania)
7:30 pm - 7:50 pm Lauren Barney (University of Massachusetts Amherst)
"Integrin Binding Uniquely Regulates Tropic Breast Cancer Cell Phenotypes In Vitro"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Jelena Rnjak (University of New South Wales)
"Engineering Biomimetic Materials by Utilizing the Multifaceted Role of Perlecan Domain V in the Vascular Niche"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Steven Caliari (University of Pennsylvania)
"Mechanically Dynamic Hydrogels for Probing Hepatic Stellate Cell Response in Fibrosis and Regression"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Brendon Baker (Boston University)
"Mesenchymal Stem Cell Mechanosensing in Engineered Fibrillar Microenvironments"
9:20 pm - 9:30 pm Discussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMolecular Mechanisms of Cell-ECM Signaling
Discussion Leaders: Jorge Valdez (Massachusetts Institute of Technology) and Colin Choi (Boston University)
9:00 am - 9:20 am Guanqing Ou (University of California Berkeley)
"Extracellular Matrix Stiffness Potentiates EGFR Activation and Endocytosis in Mammary Epithelial Cells"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Ruchi Malik (Fox Chase Cancer Center)
"Desmoplastic Stroma Affects Growth and Invasion of Progressively Mutated Human Pancreatic Cancer Cell In Vitro"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am De-Yao Wang (University of Manchester)
"The Role of Integrin Mediated Adhesions in Neuronal Mechanosensing"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Karin Wang (Cornell University)
"Early Tumor-Associated Fibronectin Matrices Promote the Development of a Tumor Microenvironment"
10:50 am - 11:00 am Discussion
11:00 am - 12:30 pmPoster Session II (Last Names Beginning N-Z)
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentor Roundtable Discussion
Discussion Leaders: Jason Burdick (University of Pennsylvania) and Linda Griffith (Massachusetts Institute of Technology)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Contributors

Conference Links

Conference History Signal Transduction by Engineered Extracellular Matrices
Additional Fee Info

Signal Transduction by Engineered Extracellular Matrices
July 21 - 26, 2024


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