Sunday Evening
(Session chair: Filippo Giancotti) | Keynote Talk |
- TONY PAWSON, Mount Sinai Hospital, Toronto, Canada.
Signaling by adhesion receptors and modular adaptor proteins.
Tony Pawson is a world-renowned scientist who has made fundamental contributions to our understanding of the roles of adaptor proteins in signaling. He will give an overview of the role of adaptor proteins in signaling and also present data on the biochemical and genetic analysis of ephrins and their receptors.
Sunday Evening
(Session Chair: Mark Peifer) | Cadherin/ß-catenin Signaling I |
The first session will focus on the genetic analysis of the Wnt/ß-catenin signaling pathway in Drosophila and Xenopous embryos with special emphasis on the influence of cadherins on this signaling pathway.
- RANDALL MOON, University of Washington, Seattle, WA, USA
Wnt/frizzled signaling in vertebrates
- MARK PEIFER, University of North Carolina, Chapel Hill, NC, USA.
Cell Adhesion, signal transduction and cancer: the Armadillo connection.
Monday Morning
(Session Chair: Barry Gumbiner) | Cadherin/ß-catenin Signaling II |
The speakers of the second session will report on biochemical studies of the cytoplasmic axin/APC/GSK-3 complex and nuclear ß-catenin/TCF complex in mammalian cells and Xenopous embryos. In combination with the genetic data, these novel exciting results will provide a mechanistic framework to understand the function of cadherins in development and cancer.
- WALTER BIRCHMEIER, Max Delbruck Center for Molecular Medicine, Berlin, Germany.
Role of ß-catenin in cell adhesion and nuclear signaling.
- PAUL POLAKIS, Genentech, San Francisco, CA, USA.
ß-catenin degradation by the axin/APC/GSK-3 complex.
- AL REYNOLDS, Vanderbilt University, Nashville, TN, USA.
Inhibition of RhoA by p120 catenin (short talk).
- BARRY GUMBINER, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Cadherin/ß-catenin signaling in Xenopus embryos and tumor cells.
Monday Night
(Session Chair: Joan Brugge) | Membrane-proximal Events in Integrin Signaling |
The first three speakers of this session will discuss the signaling events elicited by integrins upon binding to matrix and clustering on the plasma membrane (outside-to-inside signaling). The main focus will be on the mechanisms by which integrins activate Src-family kinases. Mark Ginsberg will report on newly identified cytoplasmic and membrane proteins which regulate integrin affinity (inside-to-outside signaling).
- TOM PARSONS, University of Virginia, Charlottesville, VA, USA.
Focal adhesion kinase signaling - where and when?
- MARK GINSBERG, The Scripps Research Institute, La Jolla, CA, USA.
α chain-specific integrin signaling, another tale
- EUGENE MARCANTONIO, Columbia University, NY, USA.
Dissection of integrin signaling pathways via receptor mutants.
- JOAN BRUGGE, Harvard University, Boston, MA, USA.
Integrin receptor signaling through Syk and Vav in hematopoietic cells.
Tuesday Morning
(Session Chair: Julian Downward) | Integrin-Growth Factor Receptor Cross-talk |
This session will focus on the signaling pathways responsible for anchorage-dependent survival and proliferation. The speakers will illustrate various mechanisms by which integrin- and growth factor receptor-dependent signals are integrated within the cytoplasm and in the nucleus.
- MARTIN SCHWARTZ, The Scripps Research Institute, La Jolla, CA, USA.
MAP kinases and Rho family GTPases in integrin signaling.
- KRISTIINA VUORI, The Burnham Institute, La Jolla, CA, USA.
Tyrosine phosphorylation events in integrin signaling.
- RUDY JULIANO, University of North Carolina, Chapel Hill, NC, USA.
Regulation of the stability of integrin signaling complexes.
- JULIAN DOWNWARD, Imperial Cancer Research Fund, London, UK.
Anti-apoptotic signaling from cell-matrix and cell-cell contacts.
Tuesday Night
(Session Chair: Dafna Bar-Sagi) | Regulation of the Cytoskeleton |
This session will examine in detail the coordinate regulation of the cytoskeleton and cell growth by integrins, as well as the ability of R-Ras to influence integrin association with the cytoskeleton and binding to matrix.
- ALAN HALL, University College London, London, UK
Regulation of the actin cytoskeleton by Rho GTPases
- KEITH BURRIDGE, University of North Carolina, Chapel Hill, NC, USA.
Focal Adhesions: upstream and downstream signaling.
- PHIL SORIANO, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Adhesion signaling in mouse development
- DAFNA BAR-SAGI, State University of New York at Stony Brook, Stony Brook, NY, USA.
Ras signaling and growth control.
Wednesday Morning
(Session Chair: Jean Wang) | Control of the Cell Cycle by Integrins |
The speakers of this session will discuss the connections of integrin signaling with the cell cycle machinery.
- RICK ASSOIAN, University of Pennsylvania, Philadelphia, PA, USA.
Growth factor and ECM signaling to cyclins and cdk inhibitors.
- GUIDO TARONE, University of Torino, Torino, Italy
ß1 integrin cytoplasmic domain: interactors and role in cell adhesion and signaling
- FILIPPO GIANCOTTI, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.Integrin signaling to ERK.
- BEN WILLIAMS, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Integrin signaling during C. elegans muscle development (short talk).
- JEAN WANG, University of California, San Diego, CA, USA.
Integrative signaling through c-Abl Tyrosine kinase: from adhesion to DNA damage.
Wednesday Night
(Session Chair: Ken Yamada) | Protein Tyrosine Phosphatases |
This session will cover the expanding role of protein tyrosine phosphatases in both cadherin and integrin-mediated signaling.
- SHEILA THOMAS, Harvard University, Cambridge, MA, USA.
Regulating phosphorylation in focal adhesions.
- PIER PAOLO PANDOLFI, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Genetic Analysis of PTEN.
- KEN YAMADA, National Institutes of Health, Bethesda, MD, USA.
PTEN and integrins in cell migration and apoptosis.
Thursday Morning
(Session Chair: Elaine Fuchs) | Adhesive Signaling in Vascular and Epidermal Development |
Adhesion receptors play a crucial role in both epidermal and vascular development. The speakers in this session have used of a combined biochemical and genetic approach to study the role of adhesive signaling in the context of developing tissues. They will present new exciting data on different classes of adhesion receptors within each system.
- RICHARD HYNES, M.I.T., Boston, MA, USA.
Genetic analysis of integrin function during vasculogenesis and angiogenesis in mice.
- DAVID CHERESH, The Scripps Research Institute, La Jolla, CA, USA.
Integrins and signaling events in angiogenesis.
- FIONA WATT, Imperial Cancer Research Fund, London, UK.
Role of ß1 integrins in regulating epidermal differentiation and morphogenesis.
- ELAINE FUCHS, University of Chicago, Chicago, IL, USA.
Intercellular adhesion in stratified epithelia.
Thursday Night
(Session Chair: Lou Reichardt) | Adhesive Signaling during Neural Development |
This session will focus on the mechanisms by which neurons seek out, recognize, and establish connections with their targets. The issues discussed lie at the essence of the cell-cell recognition problem crucial to all developing tissues.
- JOHN FLANAGAN, Harvard University, Boston, MA, USA.
Ephrins and Eph-receptors in retinotectal axon guidance.
- STEPHEN ROBBINS, The University of Calgary, Calgary, Canada.
EphrinA modulates cell adhesion and morphology in an integrin-dependent manner (short talk).
- BING CHENG WANG, Case Western University, Cleveland, OH, USA.
Eph Kinase regulation of cell adhesion, migration, and proliferation: Role of FAK and Ras (short talk).
- LOU REICHARDT, University of California, San Francisco, CA, USA.
Integrin function in neural development.
| Late breaking chosen from abstracts |
4-6 talks
|
