SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | MECHANISM OF INTEGRIN ACTIVATION |
| Discussion Leader: Clare Waterman (NIH/NHLBI) |
7:45 pm - 8:30 pm | Timothy Springer (Harvard Medical School)
"The traction force model for integrin activation" |
8:30 pm - 9:00 pm | Discussion |
9:00 pm | Mixer / Informal Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADHESION SIGNALLING IN CELL FUNCTION |
| Discussion Leader: Joan Brugge (Harvard Medical School) |
9:00 am - 9:30 am | Martin Humphries (University of Manchester)
"Application of proteomic technologies to analyses of adhesion receptor signalling" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Alan Howe (University of Vermont)
"Regulation of leading edge dynamics through cross-talk between calcium and Protein Kinase A" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Joan Brugge (Harvard Medical School)
"Adhesion control of morphogenesis and oncogenesis" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Jos Van Rijssel (Sanquin Research Amsterdam)
"The role of the GEF Trio in ICAM-1-mediated leukocyte transendothelial migration" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Bernie Wehrle-Haller (University of Geneva)
"Regulation of integrin clustering by modification of the membrane lipid environment" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ADHESION PROTEIN STRUCTURE |
| Discussion Leader: Sharon Campbell (University of North Carolina School of Medicine) |
7:30 pm - 8:00 pm | Sharon Campbell (University of North Carolina School of Medicine)
"Alternative models for how the vinculin tail domain binds and bundles F-actin" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Jianfeng Chen (Shanghai Institute of Biochemistry and Cell Biology)
"A novel cation-p interaction regulates ligand binding affinity and signaling of integrin α4β7" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Achilleas Frangakis (European Molecular Biology Laboratory)
"The structure of the desmosome" |
9:00 pm - 9:10 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MECHANOSENSING |
| Discussion Leader: Martin Schwartz (University of Virginia) |
9:00 am - 9:30 am | Ning Wang (University of Illinois)
"Mechanics and pluripotency of embryonic stem cells" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Sergey Plotnikov (NHLBI)
"Paxillin Phosphorylation Is a Local Regulator of Mechanotransduction Within Individual Focal Adhesions" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Martin Schwartz (University of Virginia)
"Mechanotransduction and force transmission by adhesion proteins" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Michelle Wozniak (UPenn)
"Cell shape regulates proliferation by controlling SRF-mediated transcription" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Christopher Chen (University of Pennsylvania)
"Cell shape, adhesion, and forces: The ties that bind" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ADHESION PROTEIN BIOPHYSICS |
| Discussion Leader: Michael Sheetz (Columbia University) |
7:30 pm - 8:00 pm | Michael Sheetz (Columbia University)
"Mechanotransduction by Protein Stretching: In Vivo Measurements of Timing and Displacement" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Tobias Busch (Max Planck Institute for Metals Research)
"Habloinsufficiency in NF2 alters the mechano-sensoric of primary human fibroblasts" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Deborah Leckband (University of Illinois at Urbana-Champaign)
"Signaling and mechanotransduction at intercellular junctions" |
9:00 pm - 9:10 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADHESION SIGNALING IN DISEASE |
| Discussion Leader: Alissa Weaver (Vanderbilt University Medical Center) |
9:00 am - 9:30 am | Albert Reynolds (Vanderbilt University Medical Center)
"The APC's of p120, Kaiso and Colon Cancer" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Erik Danen (Leiden University)
"A new mode of integrin-Ecadherin cross talk that modulates invasion and metastasis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Alissa Weaver (Vanderbilt University Medical Center)
"Invadopodia regulation by adhesion signaling" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Juliana Lewis (Tufts University)
"ADAP Controls the Stability and Movement of SLP-76 Microclusters" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Konstantin Burakov (The University of Chicago)
"Signaling by cell junctions: mechanisms of endothelial barrier protection by oxidized phospholipids" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | ADHESION REGULATION IN DEVELOPMENT AND TISSUE MAINTENANCE |
| Discussion Leader: Douglas DeSimone (University of Virginia School of Medicine) |
7:30 pm - 8:00 pm | Reinhard Fassler (Max Planck Institute of Biochemistry)
"Integrin signals control plasma membrane targeting of caveolae" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Takashi Watanabe (Nagoya University)
"Numb controls E-cadherin endocytosis acting through p120catenin with aPKC" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Douglas DeSimone (University of Virginia School of Medicine)
"Force, Cell-Cell Adhesion and the Regulation of Collective Cell Migration" |
9:00 pm - 9:10 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADHESION DYNAMICS |
| Discussion Leader: Alan Rick Horwitz (University of Virginia School of Medicine) |
9:00 am - 9:30 am | W. James Nelson (Stanford University)
"Regulation of actin organization and function by the cadherin-catenin complex" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Robert Harmon (Northwestern)
"Erbin Mediates The Promotion of Epidermal Differentiation By Desmoglein-1" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Alan Rick Horwitz (University of Virginia School of Medicine)
"Organizing Adhesions and Directing Cell Migration" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Shaohua Li (Robert Wood Johnson Medical School)
"Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Alpha Yap (University of Queensland)
"Cytoskeletal regulation of cadherin receptor dynamics" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INTEGRIN/CADHERIN ACTIVATION |
| Discussion Leader: David Calderwood (Yale University School of Medicine) |
7:30 pm - 8:00 pm | David Calderwood (Yale University School of Medicine)
"Cooperation between talin and integrin co-activators" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Binghao Luo (LSU)
"Dissociation of the α-subunit Calf-2 domain and the β-subunit I-EFG4 domain in integrin activation and signaling" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Barry Honig (Columbia University)
"How adhesive dimerization drives junction formation: primary events in cadherin-mediated signaling" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm | Mixer |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |