SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:00 pm | Keynote Presentation |
7:40 pm - 8:40 pm | Mina Bissell (Lawrence Berkeley Laboratory)
"Extracellular matrix remodeling and regulation in breast morphogenesis and cancer" |
8:40 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Integrin Signaling to the Cytoskeleton and Cell Migration |
| Discussion Leader: Gaudenz Danuser (Harvard Medical School) |
9:00 am - 9:30 am | Gaudenz Danuser (Harvard Medical School)
"Coordination of leading edge activities in cell motility" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | David Calderwood (Yale University)
"Integrin cytoplasmic domain interactions" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Mark Ginsberg (UCSD)
"Regulation of Rho GTPases by integrins" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Adam Simpson (Yale)
"Direct activation of Arg by integrins" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Dorit Hanien (Burnham)
"High resolution analysis of focal adhesion structure" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Ghaffar Muharram (Turko, Finland)
"A novel signalling nexus involving Met, integrins and tensins regulates carcinoma cell migration and proliferation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cadherin Signaling to the Cytoskeleton |
| Discussion Leader: Alpha Yap (Inst. for Molecular Bioscience, Queensland Bioscience Precinct) |
7:30 pm - 8:00 pm | Alpha Yap (Inst. for Molecular Bioscience, Queensland Bioscience Precinct)
"Myosin in cadherin-dependent junction formation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Karl Matter (UCL)
"Regulation of Rho GTPases by cadherins" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Jessica Maiers (University of Iowa)
"αCatenin Couples The Assembly of Tight Junctions to Adherens Junctions" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Ilse Timmerman (Sanquin Institute, Amsterdam)
"The GEF Trio regulates endothelial adherens junctions through the small GTPase Rac1" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cadherin Signaling in Growth and Differentiation |
| Discussion Leader: Elaine Fuchs (Sloan Kettering Memorial) |
9:00 am - 9:30 am | Elaine Fuchs (Sloan Kettering Memorial)
"Cadherins in skin development and cancer" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Denise Montell (Johns Hopkins)
"Cadherins as migration receptors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Dietmar Vestweber (Max Planck Institute for Molecular Biomedicine, Germany)
"Signaling by VE-cadherin" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Keely Mui (University of Pennsylvania)
"Stiffness-induced expression of N-cadherin is essential for FAK-mediated cell cycling" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Brian Coon (Yale)
"VE-cadherin molecular interactions in fluid shear stress signaling" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Sarita Sastry (University of Texas)
"PTP-PEST targets a novel tyrosine in p120ctn to control epithelial cell motility and Rho GTPase signaling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Integrin Signaling in Growth, Differentiation and Survival |
| Discussion Leader: Valerie Weaver (UCSF) |
7:30 pm - 8:00 pm | Valerie Weaver (UCSF)
"Signaling in 3 Dimensions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Eun-Gook Kim (Korea)
"Survival signaling through the paxillin complex" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Lester Lau (University Illinois at Chicago)
"Control of senescence through CCN proteins" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanotransduction by Cell Adhesion Receptors |
| Discussion Leader: Clare Waterman (NIH) |
9:00 am - 9:30 am | Clare Waterman (NIH)
"Force-dependent adhesion and cytoskeletal dynamics" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Michael Sheetz (Columbia)
"Talin in rigidity sensing" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Johan deRooij (Utrecht, Netherlands)
"Cadherin-dependent force sensing" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Vincent Fiore (Georgia Tech)
"Force-mediated synergistic binding between syndecan-4 and β1 integrin" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Bigyam Bista (MIT)
"Adhesion-GPCRs in Breast Cancer Progression and Metastasis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Torsten Shoneberg (University of Leipzig)
"G protein coupling of adhesion receptors" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Signaling by other Adhesion Receptors |
| Discussion Leader: Michael Simons (Yale University) |
7:30 pm - 8:00 pm | Michael Simons (Yale University)
"Signaling by syndecan 4 in vascular development and angiogenesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Eleni Tzima (UNC Chapel Hill)
"Signaling by PECAM-1 in atherosclerosis and artery remodeling" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Erik Sahai (CRUK London)
"Discoidin Domain receptor 1 in cell motility and cancer" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Hippo/Yap Pathway |
| Discussion Leader: Barry Gumbiner (University of Virginia) |
9:00 am - 9:30 am | Barry Gumbiner (University of Virginia)
"Cadherin regulation of the Hippo pathway" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Sergey Tryanovsky (Northwestern University)
"Actin-binding domain of alpha-catenin provides cadherin clusters with extra strength and guides their movement" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Yu Shi (Nanyang Technical University, Singapore)
"NCAM Potentiates Invasion and Metastasis of Melanoma Cells through CAMP Dependent Protein Kinase and Phosphatidylinositol 3-Kinase Pathways" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Stephan Piccolo (University of Padua, Milan, Italy)
"Mechanotransduction through the YAP/TAZ pathway" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | John Lamar (MIT)
"Roles for YAP and the Hippo Pathway during tumor progression and metastasis" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Fumihiko Nakamura (Brigham and Womens Hospital)
"Visualizing filamin A's integrin-binding site activation in living cells" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Koen van den Dries (Nijmegen)
"Podosomes by high-resolution bioimaging: actin pillars with guy ropes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems Biology Approaches to Adhesion Receptor Biology |
| Discussion Leader: Martin Humphries (University of Manchester) |
7:30 pm - 8:00 pm | Martin Humphries (University of Manchester)
"Mass spectral analysis of integrin interactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Alexander Bershadsky (Weizmann Institute)
"siRNA screens for determinants of rigidity sensing" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Joan Brugge (Harvard)
"Screening approaches for identifying migration and invasion genes" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |