SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Martin Humphries (University of Manchester, UK) |
7:40 pm - 8:20 pm | Jean Paul Thiery (National University of Singapore and A*STAR)
"Ancestry of Adhesion: How Far Have We Come and What Is There Still to Learn?"
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8:20 pm - 8:40 pm | Discussion |
8:40 pm - 9:30 pm | TBA |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Spatial Control of Adhesion Signaling |
| Discussion Leader: Jim Norman (Beatson Institute, Glasgow, UK) |
9:00 am - 9:25 am | Olivier Rossier (Interdisciplinary Institute for Neuroscience, University of Bordeaux, France)
"The Inner Life of Adhesion Sites: Integrins and Related Molecules Dynamics at the Nano-Scale"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Tony Kanchanawong (National University of Singapore)
"Role of Talin in Determining Nanoscale Architecture of Focal Adhesions"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
11:00 am - 11:25 am | Johanna Ivaska (VTT, Turku, Finland)
"Integrin Activity and Traffic in Cancer"
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11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Tina Izard (Scripps Research Institute)
"Lipid-Directed Cytoskeletal Protein Oligomerization at Sites of Cell Adhesion"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Kabir Biswas (National University of Singapore)
"E-Cadherin Junction Formation Involves an Active Nucleation Process"
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12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Ana Pasapera (National Institutes of Health)
"Integrin-Rac1- and PKC Signaling Regulate Myosin IIA Phosphorylation to Enhance Its Recruitment to Focal Adhesions, Cell Migration and ECM Mechanosensing"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cellular Niches and Tissue Architecture |
| Discussion Leader: Martin Schwartz (Yale University) |
7:30 pm - 7:55 pm | Chris Chen (Boston University)
"Mechanotransduction in 3D Matrices: New Layers to an Old Paradigm"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Cay Kielty (University of Manchester, UK)
"Microenvironmental Regulation of Mesenchymal Stem Cell Fate"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Fiona Watt (Kings College London, UK)
"Regulation of Epidermal Stem Cell Fate by Adhesion Receptor Signalling"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Olga Iendaltseva (Leiden University, Netherlands)
"Force Sensing and Transmission in Human Induced Pluripotent Stem-Cell-Derived Pericytes"
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9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adhesion Control of Cell Division and Polarity |
| Discussion Leader: Anna Akhmanova (Utrecht University, Netherlands) |
9:00 am - 9:25 am | Senthil Muthuswamy (Cold Spring Harbor Laboratory, New York)
"Cell Polarity Proteins, Cell-Cell Cohesion and Metastasis"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Francis Barr (University of Oxford, UK)
"Links Between Adhesion and Cytokinesis"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
11:00 am - 11:25 am | Torsten Wittmann (UCSF)
"Mechanisms of Microtubule-Mediated Focal Adhesion Turnover"
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11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Niels Heemskerk (Sanquin Research Landsteiner Laboratory, Amsterdam, Netherlands)
"A RhoA-Mediated Transmigratory Pore Facilitates Neutrophil Transendothelial Migration"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Matt Jones (University of Manchester, UK)
"Cell Cycle-Dependent Regulation of Adhesion Complexes"
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12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Martijn Gloerich (Stanford University)
"Molecular Basis for Mitotic Spindle Orientation by E-Cadherin-Mediated Cell-Cell Adhesion"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | In Vivo Models of Adhesion Signaling in Development |
| Discussion Leader: Arnoud Sonnenberg (NKI, Amsterdam, Netherlands) |
7:30 pm - 7:55 pm | Tony Koleske (Yale University)
"Integrin-Mediated Control of Dendrite and Dendritic Spine Stability"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Magda Zernicka-Goetz (University of Cambridge)
"ECM Directs Morphogenesis of Pluripotent Cells in the Implanting Mouse Embryo"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Rodrigo Fernandez-Gonzalez (University of Toronto, Canada)
"Junctional and Cytoskeletal Dynamics at the Interface: Mechanisms of Coordinated Cell Migration in Embryonic Wound Repair"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mark Bass (University of Bristol, UK)
"A Coronin-1C/RCC2 Complex Guides Mesenchymal Migration by Trafficking Rac1 and Controlling GEF Exposure"
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9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tension Sensing and Signaling |
| Discussion Leader: Chris Chen (Boston University) |
9:00 am - 9:25 am | Mark Smith (Huntsman Cancer Institute, University of Utah)
"Mechanically Induced Focal Regulation of Actin"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Martin Schwartz (Yale University)
"Integrin Alpha Subunit Specific Signaling and Blood Vessel Remodeling"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
11:00 am - 11:25 am | Kun-Liang Guan (UCSD)
"Regulation of The Hippo Tumor Suppressor Pathway by GPCR Signaling"
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11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Ben Goult (University of Leicester, UK)
"Talin, a Master Mechanosensor Regulating Adhesion Assembly" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Konstantin Birukov (University of Chicago)
"Focal Adhesions Control Stretch-Induced Rho Signaling and Vascular Permeability via Paxillin-GEF-H1 Functional Complex"
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12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Andrew Doyle (National Institutes of Health)
"The Local 3D Microenvironment Controls Adhesion Dynamics and Cell Motility by Balancing Forces at the Leading Edge"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Cytoskeletal Regulation |
| Discussion Leader: Johanna Ivaska (VTT, Turku, Finland) |
7:30 pm - 7:55 pm | Anna Akhmanova (Utrecht University, Netherlands)
"The Role of Microtubules in Regulation of Epithelial Organization and Migration in 3D Environment"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Andrea McClatchey (Harvard University)
"The Function of Merlin/ERM Proteins in Adhesion Remodeling During Lumen Formation"
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8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | James Nelson (Stanford University)
"Mechanotransduction at Cell-Cell Junctions"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Colleen Skau (National Institutes of Health)
"A Novel Actin-Adhesion Structure Involved in Nuclear Positioning Requires the Formin FMN2"
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9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Cell Migration |
| Discussion Leader: Val Brunton (University of Edinburgh, UK) |
9:00 am - 9:25 am | Carl-Philipp Heisenberg (Institute of Science and Technology, Vienna, Austria)
"Cell and Tissue Mechanics in Zebrafish Gastrulation"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Kozo Kaibuchi (University of Nagoya, Japan)
"Roles of the Rho Family Gtpases and Related Kinases in Polarized Migration"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
11:00 am - 11:25 am | Dylan Burnette (Vanderbilt University, Nashville)
"How Cells Shape Themselves to Substrates with Diverse Geometries"
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11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Ryan Petrie (NIDCR, NIH)
"Generation of Polarized Pressure by a Nuclear Piston Governs Integrin-Dependent 3D Cell Motility"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Madeleine Oudin (MIT)
"Haptotaxis: New Mechanistic Insight into How Cells Migrate on FN Gradients and How this Might Affect Tumor Progression"
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12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Pontus Nordenfelt (Harvard Medical School)
"Visualizing Integrin Activation by Actin-Mediated Force During T Cell Migration"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tumor Cell Invasion and Adhesion Signaling Therapies |
| Discussion Leader: Martin Humphries (University of Manchester, UK) |
7:30 pm - 7:55 pm | Jim Norman (Beatson Institute, Glasgow, UK)
"Membrane Trafficking Links Cell Migration and Invasion to Energy Metabolism During Metastasis"
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7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alpha Yap (University of Queensland, Brisbane, Australia)
"Tension-Sensing at Cell-Cell Junctions: Coordinating Collective Cell Responses to Loss of Epithelial Integrity" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Val Brunton (University of Edinburgh, UK)
"Adhesion Regulators and Tumour Progression"
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9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Kairbaan Hodivala-Dilke (Barts Cancer Institute, Queen Mary University of London)
"Endothelial-FAK Targeting Sensitises Tumours to DNA-Damaging Therapy"
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9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |