Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Perspectives in Adhesion and
Homeostasis |
| Discussion Leaders: Alpha Yap (The University of Queensland, Australia) and Christopher Chen (Boston University / Harvard University, USA) |
7:40 pm - 8:15 pm | Ian Macara (Vanderbilt University Medical Center, USA) "Unexpected Roles for Polarity Proteins in the Life and Death of Epithelial Cells" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Selected from Poster Abstracts: Madeleine Oudin (Massachusetts Institute of Technology, USA) "Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis During Metastatic Progression" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) "Mechanical Stretch Triggers Rapid Epithelial Cell Division Through the Stretch-Activated Channel Piezo 1" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Mechanisms in Cell Adhesion |
| Discussion Leader: Maddy Parsons (King's College London, United Kingdom) |
9:00 am - 9:25 am | William Weis (Stanford University, USA) "Force-Dependent Molecular Interactions in Adherens Junction Assembly" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Vinay Swaminathan (National Heart, Lung, and Blood Institute, NIH, USA) "Actin Retrograde Flow Orients and Aligns Activated, Ligand-Engaged Integrins in Focal Adhesions" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Ben Goult (University of Kent, United Kingdom) "The Emerging Role of Talin as a Mechanosensitive Signalling Platform" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Nicholas Brown (University of Cambridge, United Kingdom) "Integrating Adhesome Components into a Functional Machine" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Satyajit Mayor (National Centre for Biological Sciences, India) "Local Membrane Organization and Integrin Signaling" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Alessandra Cambi (Radboud University Medical Center, The Netherlands) "Nanoscale Architectures and Mesoscale Dynamics of Mechanosensory Podosomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) and Madeleine Oudin (Massachusetts Institute of Technology, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Myosin and Adhesion: Its Roles as Force Generator and Scaffold |
| Discussion Leader: Kris DeMali (University of Iowa, USA) |
7:30 pm - 7:55 pm | John Hammer (National Heart, Lung, and Blood Institute, NIH, USA) "Mixing and Matching Myosins to Drive Functional Diversity" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Margaret Gardel (The University of Chicago, USA) "A Mechanochemical Feedback to Regulate Cell Elasticity" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Vivian Tang (University of Illinois at Urbana-Champaign, USA) "Propagating Cortical Actomyosin-Generated Tension to Intercellular Adhesion Complex by Myosin-1c" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Colleen Skau (National Institutes of Health, USA) "An FMN2-Mediated Perinuclear Actin/Adhesion System Protects Against DNA Damage During Confined Cell Migration" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Adhesion Signaling |
| Discussion Leader: Tony Koleske (Yale University, USA) |
9:00 am - 9:25 am | Ann Miller (University of Michigan, USA) "Regulation of Localized RhoA Activity and Cell-Cell Junction Remodelling in Dividing Epithelial Cells" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jay Groves (University of California, Berkeley, USA) "Mechanical Aspects of Signaling at Cell-Cell Junctions" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Rishita Changede (Mechanobiology Institute, National University of Singapore, Singapore) "Nascent Integrin Adhesions Form on All Matrix Rigidities After Integrin Activation" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Hilary Ashe (University of Manchester, United Kingdom) "Enhancement of the BMP Pathway by Integrin Signalling in Drosophila" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Valerie Horsley (Yale University, USA) "Epithelial and Stromal Players in Skin Tissue Adhesion and Matrix Deposition" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Yusuke Toyama (Mechanobiology Institute, National University of Singapore, Singapore) "Tension-Dependent Vinculin Dynamics at Adherens Junction During Cell Boundary Oscillation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inside-Out Integrin Signaling: Revisiting a Controversy |
| Discussion Leader: Nicholas Brown (University of Cambridge, United Kingdom) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | David Calderwood (Yale University, USA) "How Important Is Inside-Out Signaling in Non-Hemopoeitic Cells?" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Martin Humphries (University of Manchester, United Kingdom) "Primordial Connections Between the Adhesion Nexus and Cell Proliferation" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Guy Tanentzapf (University of British Columbia, Canada) "Regulation of Integrin-Mediated Adhesion in Tissue Development and Homeostasis" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adhesion and Tissue Homeostasis |
| Discussion Leader: Erin Cram (Northeastern University, USA) |
9:00 am - 9:25 am | Jay Humphrey (Yale University, USA) "Mechanoregulation of Matrix in Vascular Homeostasis and Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Anna Huttenlocher (University of Wisconsin-Madison, USA) "Chemokines and Bidirectional Migration" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Michael Smutny (Institute of Science and Technology Austria, Austria) "E-Cadherin-Dependent Friction Force Is a Major Driver of Tissue Morphogenesis in Zebrafish Development" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | John Wallingford (University of Texas at Austin, USA) "Pushing and Pulling: Understanding Cell Movement in Vertebrate Embryos" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany) "Signaling, Cell Polarity and Adhesion During Cardiac Trabeculation" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Jocelyn McDonald (Kansas State University, USA) "Detachment Versus Cohesion: Novel Roles for PDZ-GEF and Rap1 During Collective Cell Migration" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | New Approaches to Integrate Across Biological Scales |
| Discussion Leader: Anand Asthagiri (Northeastern University, USA) |
7:30 pm - 7:55 pm | Celeste Nelson (Princeton University, USA) "Adhesions and Forces in Tissue Origami" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Virgile Viasnoff (Mechanobiology Institute, National University of Singapore, Singapore) "Control of Cell-Cell Contact Polarization by Mechanical Forces" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Christopher Chen (Boston University / Harvard University, USA) "Forces, Adhesions and Mechanotransduction in a Multicellular Context" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease: Adhesion and Its Discontents |
| Discussion Leader: Andrew Gladden (University of Texas MD Anderson Cancer Center, USA) |
9:00 am - 9:25 am | Peter Friedl (Radboud University Medical Center, The Netherlands) "Balancing Cell-Cell Interactions and Tissue Mechanics During Cancer Invasion" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Corinne Albiges-Rizo (Institut Albert Bonniot, Université Joseph Fourier / CNRS, INSERM, France) "Cell Contractility and Tissue Integrity" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Edna Cukierman (Fox Chase Cancer Center, Temple Health, USA) "Integrins in Epithelial Cancer Desmoplastic-to-Homeostatic Stroma Remodeling" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Martin Schwartz (Yale School of Medicine, USA) "Mechanotransduction in Vascular Health and Disease" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Weilan Ye (Genentech Inc., USA) "Modulating Integrin a5b1 Adhesive Property to Alter Drug Delivery and Lymphocyte Trafficking" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Xiaoyang Wu (University of Chicago, USA) "ACF7 Regulates Cell/Cell Junctions in Intestinal Epithelium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems Approaches to Quantitative Analysis |
| Discussion Leader: Brenton Hoffman (Duke University, USA) |
7:30 pm - 7:55 pm | Valerie Weaver (University of California, San Francisco, USA) "Signaling in the 3rd Dimension: A Biophysical Perspective" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alexander Mogilner (Courant Institute of Mathematical Sciences, New York University, USA) "Quantitative Adhesion Dynamics in Spontaneous and Induced Cell Motility Initiation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Xavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain) "Epithelial Tissues as Active Materials Controlled by Cell-Cell Forces" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |