Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Insights on Old Pathways
Discussion Leader: Christopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
7:40 pm - 8:25 pm
Joan Brugge (Harvard Medical School, USA)
"Cancer Therapy Resistance: A Cell Biologist’s Perspective"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Nicole King (University of California, Berkeley, USA)
"Regulation of Multicellularity in Choanoflagellates: An Evolutionary Perspective on Adhesion"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion Assembly and Disassembly
Discussion Leader: Douglas DeSimone (University of Virginia, USA)
9:00 am - 9:25 am
Alpha Yap (University of Queensland, Australia)
"Mechanochemical Feedback and Signaling at the Epithelial Adherens Junction"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Kathleen Green (Northwestern University, USA)
"Desmosomes in Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Matthew Kutys (Boston University, USA)
"Tumor Suppressive, Non-Canonical Notch1 Regulation of Epithelial Adherens Junctions and Mitogenic Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Ronen Zaidel-Bar (Sackler School of Medicine, Tel Aviv University, Israel)
"Non-Junctional Cadherin in Regulating Actomyosin and Cortical Dynamics"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Minnah Thomas (Mechanobiology Institute, National University of Singapore, Singapore)
"Desmosome Regulates the Junctional Interface and Actomyosin Dynamics During Apoptotic Cell Extrusion"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Adam Kwiatkowski (University of Pittsburgh School of Medicine, USA)
"Alpha-Catenin Integrates Cytoskeletal Networks at Cardiomyocyte Adherens Junctions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Andrea McClatchey (Massachusetts General Hospital / Harvard Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Adhesion Assembly and Disassembly
Discussion Leader: Pere Roca-Cusachs (Institute for Bioengineering of Catalonia / Universitat de Barcelona, Spain)
7:30 pm - 7:55 pm
Bernhard Wehrle-Haller (University of Geneva, Switzerland)
"Un Menage à Trois, Controlling Integrin Activation and Clustering by Talin and Kindlin"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jonathan Cooper (Fred Hutchinson Cancer Research Center, USA)
"Src and Focal Adhesion Signaling Dynamics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Margaret Gardel (The University of Chicago, USA)
"Cytoskeletal Dynamics, Adhesion Assembly and Force"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Stavroula Mili (Center for Cancer Research, National Cancer Institute, NIH, USA)
"Mechanical Regulation of RNA Localization Contributes to Cell Migration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanical Regulation of Adhesion
Discussion Leader: Wesley Legant (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:25 am
Martin Schwartz (Yale School of Medicine, USA)
"Mechanical Homeostasis of the Extracellular Matrix"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Alex Dunn (Stanford University, USA)
"Dynamics of Force Transduction at Single Integrin Complexes in Living Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Consuelo Ibar (Waksman Institute of Microbiology, Rutgers University, USA)
"Tension-Dependent Regulation of Mammalian Hippo Signaling Through LIMD1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Deborah Leckband (University of Illinois at Urbana-Champaign, USA)
"Mechanotransduction Mechanisms at Cadherin Adhesions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Valentin Jaumouillé (National Institutes of Health, USA)
"Mechanical Coupling of β2 Integrins to the Actin Cytoskeleton by a Molecular Clutch Drives Phagocytosis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Brent Hoffmann (Duke University, USA)
"Detecting Vinculin Load-Dependent Protein Recruitment to Focal Adhesions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Orchestrating Adhesion and Migration
Discussion Leader: Carien Niessen (University of Cologne, Germany)
7:30 pm - 7:55 pm
Mark Peifer (University of North Carolina at Chapel Hill, USA)
"Building the Body Plan: The Miracle of Morphogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Pere Roca-Cusachs (Institute for Bioengineering of Catalonia / Universitat de Barcelona, Spain)
"Force Loading Rate as a Fundamental Magnitude in Mechanosensing"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands)
"Invasion Mechanisms in Metastasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jessica Li Chang Teo (Institute for Molecular Bioscience, University of Queensland, Australia)
"Interplay Between Caveolae and Junctional Mechanics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesion and Tissue Remodeling
Discussion Leader: Edna Cukierman (Fox Chase Cancer Center, USA)
9:00 am - 9:25 am
Ann Miller (University of Michigan, USA)
"Regulation of Cell-Cell Junctions During Tissue Remodeling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Celeste Nelson (Princeton University, USA)
"The Physical and Cellular Basis of Branching Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Vivek Shenoy (University of Pennsylvania, USA)
"Multiscale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Kris DeMali (Carver College of Medicine, University of Iowa, USA)
"Coupling of Adhesive and Metabolic Pathways at Cell-Cell Junctions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Clémentine Villeneuve (Institut Curie, France)
"The Polarity Protein aPKCi: A New Key Player of Basal Cell Extrusion, an Emergent Mechanism for Early Tumor Cell Dissemination"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
William Brieher (University of Illinois at Urbana-Champaign, USA)
"Harnessing Actin Polymerization to Maintain Epithelial Sheets"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell-Matrix, Cell-Cell and Growth Factor Receptor Cross-Talk
Discussion Leader: Vivian Tang (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:55 pm
Andrea McClatchey (Massachusetts General Hospital / Harvard Medical School, USA)
"Role of Cell-Cell Adhesion, Merlin and ERM Proteins in EGFR Distribution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Boris Hinz (University of Toronto, Canada)
"Regulation of TGFb Signaling and Fibrogenesis by Adhesion and Matrix"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Johanna Ivaska (University of Turku, Finland)
"Cell-Matrix Crosstalk in Cancer and Pluripotency"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kayla Wolf (University of California, Berkeley, USA)
"Tumor Invasion Through Hyaluronic Acid Matrices Is Mediated by CD44-Dependent Microtentacles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolving Concepts of Adhesion Signaling and Cancer Progression
Discussion Leader: Madeleine Oudin (Tufts University, USA)
9:00 am - 9:25 am
Andrew Ewald (Johns Hopkins University, USA)
"The Varied Roles of Adhesions During Steps of Metastasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Weilan Ye (Genentech Inc., USA)
"MAP4K4, an Integrin-FERM Regulator in Cell-Cell Adhesion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Erik Linklater (University of Colorado Anschutz Medical Campus, USA)
"A Rab40b:Cullin-5 Interaction Regulates Elplin Levels to Control Stress Fiber and Focal Adhesion Formation and Affect Cell Cell Migration and Invasion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Gaudenz Danuser (University of Texas Southwestern Medical Center, USA)
"Big Data Approaches to Cancer Migration"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Paulina Moreno Layseca (Turku Centre for Biotechnology, Finland)
"Swiprosin1 Links Rab21-Containing Vesicles with the Actin Cytoskeleton to Drive Integrin Transport in Breast Cancer Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Ben Goult (University of Kent, United Kingdom)
"Deciphering the Talin Code: Understanding Mechanotransduction Using Structural Mechanobiology"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Applications of Adhesion Modulation
Discussion Leader: Albert Reynolds (Vanderbilt University, USA)
7:30 pm - 7:55 pm
Simon Goodman (Freelance, Germany)
"An Update on Anti-Integrin Therapeutic Programs"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
David Schlaepfer (University of California, San Diego, USA)
"Adhesion Signals as Cancer Targets"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Stephanie Fraley (University of California, San Diego, USA)
"Collagen Fibril Architecture Regulates Cell Adhesion, Metabolic Stress and Collective Migration"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Dean Sheppard (University of California, San Francisco, USA)
"Integrins in Inflammation and Fibrosis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure