Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Adhesion Across Scales: From Molecules to Morphogenesis
Discussion Leader: Kate Cavanaugh (University California San Francisco, United States)
7:50 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
Bob Goldstein (University of North Carolina at Chapel Hill, United States)
"C. elegans Gastrulation as a Model for Understanding How Cells Change Shape In Vivo "
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:30 pm
Kathleen Green (Northwestern University, United States)
"Linking Skin Morphogenesis and Inflammation Through Desmosomes "
9:30 pm - 9:40 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanotransduction by Adhesion Receptors
Discussion Leader: Martin Schwartz (Yale School of Medicine, United States)
9:00 am - 9:25 am
Alex Dunn (Stanford University, United States)
"Mechanoregulation of Ezrin- and PDZ-Based Adhesion Complexes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Ben Goult (University of Kent, United Kingdom)
"Talin in Mechanomemory - Spatial Organisation Encoded by Binary Mechanochemical Switches."
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Qing Deng (Purdue University, United States)
"Mitofusin 2 Regulates Cytoskeleton Reorganization During Cell Spreading and Migration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Patrick Oakes (Loyola University of Chicago, United States)
"Mechanotransduction via LIM Domain Proteins "
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Timo Kohler (University of Cambridge, United Kingdom)
"Plakoglobin is an evolutionary conserved and mechanoresponsive regulator of naïve pluripotency"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Christoph Ballestrem (University of Manchester, United Kingdom)
"Tensin3 Drives the Formation of Fibronectin-Associated Fibrillar Adhesions Through its Interaction with the Mechanosensor Talin"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Petra Gross (Journal of Cell Science, Company of Biologists, United Kingdom) and Carien Niessen (University of Cologne, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Maintaining Adhesion in Dynamic Environments
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:55 pm
Yusuke TOYAMA (National University of Singapore, Singapore)
"Cell Adhesion in Maintaining the Homeostatic Cell Number in Epithelium "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Kalle Sipilä (King's College London, Centre for Gene Therapy & Regenerative, United Kingdom)
"Embigin is a Novel Fibronectin Receptor that Regulates Sebaceous Gland Differentiation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Jennifer Zallen (Memorial Sloan Kettering Cancer Center, United States)
"Signals, Forces, and Cells: Decoding Tissue Morphogenesis "
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Andrew Kowalczyk (Penn State Hershey, United States)
"Identification and high resolution structural analysis of a novel endoplasmic reticulum-desmosome complex"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesive Control of Cell Division
Discussion Leader: Cara Gottardi (Northwestern University, United States)
9:00 am - 9:25 am
Yohanns Bellaïche (Genetics and Developmental Biology Unit (U934/UMR3215), Institut Curie, France)
"Epithelial Junctions Under Mechanical Forces "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Sarah Woolner (University of Manchester, United Kingdom)
"Mechanical Regulation of Cell Division in Complex Tissue Environments "
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Tony Tsai (Washington University in St. Louis, United States)
"Smart Glues: Coordinating Robust Pattern Formation and Morphogenesis with an Adhesion Code"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Martijn Gloerich (University Medical Center Utrecht, The Netherlands)
"Mechanical Control of Epithelial Cell Division "
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Talk Selected from GRS
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Daniel Conway (The Ohio State University, United States)
"Loss of Mechanical Homeostasis in Acini Drives Eversion, a Collective Movement of Cells that Inverts Apical-Basal Polarity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Adhesion Signaling
Discussion Leader: Andrew Kowalczyk (Penn State Hershey, United States)
7:30 pm - 7:55 pm
Rafael Garcia-Mata (University of Toledo, United States)
"Regulation of Invadopodia Dynamics by the Cdc42-Specific GAP ARHGAP17 "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Alexa Mattheyses (University of Alabama at Birmingham, United States)
"Building a Desmosome: Architectural Changes Throughout Assembly "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Antonis Kourtidis (Medical University of South Carolina (MUSC), United States)
"Actin-dependent Recruitment of Ago2 to the Zonula Adherens"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Tony Koleske (Yale University, United States)
"Disruption of Adhesive and Cytoskeletal Systems in Neurodevelopmental Disorders "
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Adhesion Signaling and Cell Migration
Discussion Leader: Brent Hoffman (Duke University, United States)
9:00 am - 9:25 am
Christopher Chen (Boston University , United States)
"Finding Like-Minded Neighbors: A Question of Likes or Dislikes "
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Dominique Alfandari (University of Massachusetts amherst, United States)
"ADAM11 Controls Neural Crest Cell EMT by Modulating BMP and Wnt Signaling"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Jocelyn McDonald (Kansas State University, United States)
""Group Activities": Regulating Adhesion in Collective Cell Migration "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Maddy Parsons (King's College London, United Kingdom)
"Epithelial Cell Adhesion Receptor Signals Mediating Lung Inflammation "
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Talk Selected from GRS
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Sally Horne-Badovinac (University of Chicago, United States)
"Cadherin-based Planar Polarization of Cell Protrusions for Rotational Epithelial Migration "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Engineering Adhesion
Discussion Leader: Karin Wang (Temple University, United States)
7:30 pm - 7:55 pm
Sanjay Kumar (University of California, Berkeley, United States)
"Mechanisms of Adhesion and Invasion in Hyaluronic Acid Matrices "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Karen Kasza (Columbia University, United States)
"Biophysical Mechanisms Controlling Epithelial Cell Rearrangements and Tissue Flows "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Katheryn Rothenberg (University of Toronto, Canada)
"Rap1 Orchestrates the Adhesion and Cytoskeletal Rearrangements that Drive Rapid Embryonic Wound Repair"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Madeleine Oudin (Tufts University, United States)
"Chemotherapy-Induced Changes in the ECM Composition of Primary Tumor and Metastatic Sites Drive Cancer Metastasis and Recurrence"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesion, Morphogenesis and Tissue Remodeling
Discussion Leader: Sally Horne-Badovinac (University of Chicago, United States)
9:00 am - 9:25 am
Scott Holley (Yale University, United States)
"Integrin Single Molecule Biophysics During Early Spinal Column Development "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Adam Martin (Massachusetts Institute of Technology, United States)
"Coordinating Tissue-Wide Cell Shape Changes During Tissue Folding "
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Robert Huebner (University of Texas at Austin, United States)
"ARVCF Catenin Links Subcellular Actomyosin Dynamics to Tissue Scale Force Production During Vertebrate Axis Extension"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Robert Krauss (Icahn School of Medicine at Mount Sinai, United States)
"Regulation of Muscle Stem Cell Form and Function by Cadherins "
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Vivian Tang (University of Illinois at Urbana-Champaign, United States)
"Contractomere is a Motorized Organelle that Can "Walk the Junction" on the Plasma Membrane"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Victor Hernandez-Gordillo (Lung Biotechnology PBC, United States)
"3D Printed Lungs to End the Organ Shortage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Adhesion and Disease
Discussion Leader: Kathleen Green (Northwestern University, United States)
7:30 pm - 7:55 pm
Asma Nusrat (University of Michigan, United States)
"Intestinal Epithelial Barrier: Insights into Junctional Signaling and Repair "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Danijela Matic Vignjevic (Institut Curie, France)
"Arp2/3 Complex Maintains Cell-Cell Junctions to Preserve Gut Epithelium Integrity "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Fang Lin (The University of Iowa, United States)
"Ga13 Controls the Convergence of Pharyngeal Endoderm by Regulating the Expression of E-cadherin"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Thijs Koorman (UMC Utrecht, The Netherlands)
"Id2 Controls Indolent Proliferation in E-cadherin Negative Breast Cancer Cells"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure