Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Life at a Higher Resolution
Discussion Leader: Julie Biteen (University of Michigan, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
W.E. Moerner (Stanford University, USA)
"Selected New Directions with Single Molecules: Methods and Biological Insights"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Jennifer Lippincott-Schwartz (Howard Hughes Medical Institute, USA)
"Unraveling the Spatial and Temporal Dynamics of Subcellular Organelles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single-Molecule Approaches in Chemistry
Discussion Leader: Ziad Ganim (Yale University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Christy Landes (Rice University, USA)
"Towards Predictive Separations One Protein at a Time"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Randall Goldsmith (University of Wisconsin-Madison, USA)
"Accessing Single-Molecule Chemical Dynamics Using Optical Microresonators"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Iddo Heller (VU University Amsterdam, The Netherlands)
"Lost and Bound Between the Basepairs: Hyperstretched and Tilted States"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Suzanne Blum (University of California, Irvine, USA)
"Organic Chemistry and Molecular Catalysts: Imaging Mechanisms at Single Particles and Molecules"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Laura Kaufman (Columbia University, USA)
"Single-Molecule Probes and Single Particles, Probed: Approaches to Studying Complex Chemical Systems"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Gabriela Schlau-Cohen (Massachusetts Institute of Technology, USA) and Christy Landes (Rice University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fundamental Cellular Processes
Discussion Leader: Erwin Peterman (Vrije Universiteit Amsterdam, The Netherlands)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
Steve Granick (IBS Center for Soft and Living Matter, South Korea)
"The Enzyme Catalysis Problem"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Matthew Lew (Washington University in St. Louis, USA)
"Towards Optimal Imaging of Single-Molecule Rotational Dynamics at the Nanoscale"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
David Rueda (Imperial College London, United Kingdom)
"From Single Molecule to Single Cells: Imaging Fundamental Nucleic Acid Enzymes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Minjoung Kyoung (University of Maryland, Baltimore County, USA)
"4D Characterization of Spatiofunctional Enzyme Assemblies in Living Cells"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Ahmet Yildiz (University of California, Berkeley, USA)
"The Mechanism of Dynein's Force Generation and Unidirectional Motility"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Photosynthesis and Energy Transfer
Discussion Leader: Claudiu Gradinaru (University of Toronto, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gabriela Schlau-Cohen (Massachusetts Institute of Technology, USA)
"Why Don't Plants Get Sunburn?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Vivek Tiwari (University of Michigan, USA)
"Spatially-Resolved Fluorescence-Detected Two-Dimensional Electronic Spectroscopy for In Vivo Studies of Photosynthetic Bacteria"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Richard Hildner (University of Bayreuth, Germany)
"Inspired by Nature: Energy Transport in Artificial Supramolecular Structures"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Maria Kamenetska (Boston University, USA)
"Measuring Charge Transport Through Single Molecules"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Rienk Van Grondelle (VU University Amsterdam, The Netherlands)
"The Quantum Design of Photosynthesis"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Allison Squires (Stanford University, USA)
"Photophysical Heterogeneity of Single Phycobilisomes Quenched by the Orange Carotenoid Protein"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Salome Veshaguri (University of Copenhagen, Denmark)
"Single Molecule Measurements of Substrate Transport by a Primary Active Proton Pumping ATPase"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single Molecules in Living Cells
Discussion Leader: Johan Elf (Uppsala University, Sweden)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Bianxiao Cui (Stanford University, USA)
"Comparing Kinesin and Dynein Motors During Axonal Transport"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jin Zhang (University of California, San Diego, USA)
"Illuminating the Biochemical Activity Architecture of the Cell"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Xiaoyu Shi (University of California, San Francisco, USA)
"Expansion STORM Enables Imaging Beyond the Superresolution Limit"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Ethan Garner (Harvard University, USA)
"Using Single-Molecule Tracking to Dissect the Cytoskeletal and Enzymatic Machines that Grow and Divide Bacteria"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Super-Resolution Imaging
Discussion Leader: Philip Tinnefeld (Ludwig Maximilian University of Munich, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Samuel Hess (University of Maine, USA)
"Localization Microscopy: Advances in Methodology for Biological Applications"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Yujie Sun (Peking University, China)
"Probing the Chromatin Structural Basis of DNA Replication Activation in Mammalian Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Rusty Nicovich (Allen Institute for Brain Science, USA)
"Spatial Transcriptomics Through Single-Molecule Imaging"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Steven Lee (University of Cambridge, United Kingdom)
"Multi-Dimensional Super-Resolution Microscopy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Suliana Manley (École Polytechnique Fédérale de Lausanne, Switzerland)
"Smart Super-Resolution Microscopy for Multi-Color 3D Reconstruction"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single-Molecule Nanophotonics and Plasmonics
Discussion Leader: Stephan Link (Rice University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Michel Orrit (Leiden University, The Netherlands)
"Exploring Dynamical Heterogeneity with Single Molecules and Single Gold Nanoparticles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Katherine Willets (Temple University, USA)
"Super-Resolution Imaging of Plasmonic Nanostructures"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Ye Tao (Rowland Institute, Harvard University, USA)
"Magnetometry at the Single-Molecule Length Scale"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Niek Van Hulst (ICFO - The Institute of Photonic Sciences, Spain)
"Single-Molecule Femto-Second Spectroscopy and Nanocavity Coupling"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Single-Molecule Mechanics
Discussion Leader: Lori Goldner (University of Massachusetts Amherst, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Steven Block (Stanford University, USA)
"What's Right, and What's Wrong, with the Kinesin Mechanochemical Cycle"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Madhavi Krishnan (University of Zurich, Switzerland)
"Single-Molecule Electrometry: Visualizing Molecular Electrostatics and 3D Conformation in an Optical Microscope"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Ashley Carter (Amherst College, USA)
"Protamine Folds DNA Before Forming Loops"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Wesley Wong (Harvard University / Boston Children's Hospital, USA)
"Probing Biomolecular Interactions with Parallel Force Spectroscopy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Sabrina Leslie (McGill University, Canada)
"Visualizing Structure-Mediated Interactions in Supercoiled DNA Molecules"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Michael Lawson (California Institute of Technology, USA)
"Characterizing Complex Phenotypes of a Library of Cells at Single Molecule Sensitivity"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Single Molecules to Complex Systems
Discussion Leader: Olga Dudko (University of California, San Diego, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Frederick MacKintosh (Rice University, USA)
"Supramolecular Signatures of Broken Detailed Balance in Living Systems"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Mark Wallace (King's College London, United Kingdom)
"Single-Molecule Imaging of Pores in Lipid Membranes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Xiaoliang Sunney Xie (Peking University, China / Harvard University, USA)
"Single-Molecule Biology: When Stochasticity Meets Precision"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure