Session 1. Genomics
Discussion Leader: John landolo (Kansas State Univ.)
- George Stewart (Kansas State Univ.)
- Karen Shaw & Skip Shimer (Schering-Plough Research Institute, Kenilworth, N.J. & Genome Therapeutics Corp, Waltham, Mass.)
Session 2. Surface proteins
Discussion Leader: T. J. Foster (Trinity College, Dublin)
- Magnus Hook (Texas A & M)
- David O'Connell (Trinity College, Dublin) - "The Clumping Factor has an integrin-like Ca2+ Inhibitory Site"
- Olaf Schneewind (UCLA) - "Staphylococcus aureus as a model system for bacterial wall targeting mechanisms"
- F. Götz (Tubigen) - "Molecular basis of biofilm formation in coagulase negative Staphylococci"
Session 3. Resistance to MLS antibiotics
Discussion Leader: Gordon Archer (MCV/VCU)
- Joyce Sutcliffe (Pfizer Central Research, Groton, CT) - "Macrolide resistance in gram positive bacteria"
- Nevine El Sohl (Institute Pasteur) - "Resistance of Staphylococci to the synergistic combinations of streptogramins A and B and related compounds"
- Keiichi Hiramatsu (Juntendo Univ.) - "a Clinical Isolate of Staphylococcus aureus with reduced susceptibility to Vancomycin"
Session 4. Epedemiology and resistance
Discussion Leader: Niels Frimodt-Moller (Statens Serum Institut, Copenhagen, Denmark)
- Barry Kreiswirth (PHRI, New York) - "Nucleotide sequencing of variable genes - the ultimate in molecular epidemiology "
- David Hooper (Mass. General, Harvard Med.) - "Fluoroquinolone resistance"
- Ron Skurray (Univ. of Sydney, Australia) - "Efflux-mediated drug resistance in Staphylococci"
Session 5. Clinical and Molecular Aspects of Staphylococcal Pathogens
Discussion Leader: Sören Gatterman (University of Mainz)
- Jerome Etienne (Hopital Edouard Herriot) - "S. Iugdenensis, an overlooked pathogen"
- Francois Vandenesch (L'Hopital Louis Pradel, Lyons) - "The molecular basis of S. lugdenensis pathogenesis (or 'Exoproteins from S. lugdenensis and their regulation')"
- Arnold Bayer (UCLA) - Pathogenesis of endocarditis - role of selected virulence factors"
Session 6. Cell Targets/Resistance to cell wall active antibiotics
Discussion Leader: Brian Wilkinson - (Illinois State Univ.)
- Brian Wilkinson (Illinois State Univ.) - "Staphylococcus aureus - penicillin - Peptidoglycan - Penicillin resistance: Historically Historically Inextricably Intertwined"
- Alex Tomasz (Rockefeller Univ.) - "Origin of Methicillin Resistance"
- Harald Labischinski - (Bayer, AG Wuppertal, Germany) - "Factors essential for methicillin resistance
as new staphylococcal targets"
- Tapan Misra (University of Illinois - Chicago) - "Characterization of Putative Stress Response Transcription Factor SigB of S. aureus"
- Michael Pucci (Bristol-Myers Squibb, Wallingford CT.) - "Genetic and Biochemical Characterization of Cell Wall Biosynthesis"
Session 7. Toxins - Structure and Function
Discussion Leader -Greg Bohach (University of Idaho) - Overview and Perspectives
- Pat Schlievert (U. of Minnesota) - "Structure-function studies of pyrogenic toxin and other superantigens"
- S. Bakhdi (Mainz, Germany) - "Alpha-toxin, basic and applied aspects"
- Hagan Bayley (Texas A&M, College Station, TX) - "Alpha-toxin structure"
Session 8. Gene Regulation & Expression
Discussion Leader: R. Novick (Skirball Institute of Biomolecular Medicine, New York Univ.)
- Richard Novick (Skirball Institute of Biomolecular Medicine, New York Univ.) - Introductory Remarks and the Role of Signalling Peptides in the Regulation of Staphylococcal Virulence
- Stefan Arvidson (Karolinska, Sweden) - "The S. aureus agr locus"
- Nancy Freitag (Wayne State Univ., Detroit, Ml.) - "Regulation of virulence gene expression within host
cells by the bacterial pathogen Listeria monocytogenes"
- Wolfgang Hillen (F. Alexander University, Erlangen Germany) - "Catabolite repression in gram positive bacteria"
Session 9. Posters
- Six poster presenters (mainly younger investigators) will be selected by the Vice Chair (Keith Dyke) to give oral presentations of their work.
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