| Sunday 9th May 19.30-21.30 |
| 14.00-21.00 | | Registration (Closed 18.00-19.00) |
| 18.00 | | Dinner |
| 19.30-19.40 | | Chairman's Welcome. |
| Session 1: Novel Therapeutic Agents |
| 19.40-19.50 | Discussion Leader:
Wright Nichols
(Zeneca, Alderley Edge, U.K.) | |
| 19.50-20.25 | Steve Projan
(Wyeth-Ayerst Research, Lederle Laboratories, Pearl River, NY, USA) | Strategies for the Discovery of Novel
Antistaphylococcal Drugs |
| 20.25-20.40 | | Discussion |
| 20.40-21.15 | Thalia Nicas
(Lilly) | New agents for resistant staphylococci: will glycopeptide be part of the solution? |
| 21.15-21.30 | | Discussion |
| 21.30-23.00 | | Welcome Reception |
| Monday 10th May 9.00-12.30 |
| Session 2: Virulence Factors |
| 9.00-9.10 | Discussion Leader:
Magnus Hook
(Texas A. & M. University, Houston, TX, USA) | |
| 9.10-9.50 | David Holden
(Hammersmith Hospital, London, U.K.) | Functional analysis of Staphylococcus aureus virulence genes identified by Signature-Tagged Mutagenesis |
| 9.50-10.05 | | Discussion |
| 10.05-10.45 | Tim Foster
(Trinity College, Dublin, Ireland.) | Fibrinogen binding proteins of S. aureus. |
| 10.45-11.00 | | Discussion |
| 11.00-11.20 | | Coffee |
| 11.20-12.00 | Paul Williams
(University of Nottingham, U.K.) | Receptor-mediated iron acquisition in the staphylococci-a new use for an old enzyme |
| 12.00-12.30 | | Discussion and General Discussion |
| Monday 10th May 17.30-19.30 |
| Session 3: Staph. genomics |
| 17.30-17.40 | Discussion Leader:
George Stewart
(Kansas State University, Manhattan, USA). | |
| 17.40-18.05 | John Iandolo
(University of Oklahoma, Oklahoma City, USA) | Sequencing the Staphylococcus aureus 8325 genome;
progress and future directions |
| 18.05-18.30 | Steven Gill
(The Institute for Genomic Research, Rockville, Madison, USA.) | Genome analysis of the MRSA strain, COL. |
| 18.30-18.50 | | Discussion |
| 18.50-19.15 | Bo Shopsin
(Public Health Research Institute, New York, USA) | Comparative DNA sequence analysis of S. aureus |
| 19.15-19.30 | | Discussion |
| 20.30-22.00 | Poster Session 1 |
| Tuesday 11th May 9.00-12.30 |
| Session 4: Animal Models of Staphylococcal Infection |
| 9.00-9.10 | Discussion Leader:
Arnie Bayer
(Harbor UCLA Medical Center, Torrance, California) | |
| 9.10-9.45 | Andrej Tarkowski
(Goteburg, Sweden.) | Host-bacterium interactions in experimental S. aureus arthritis and sepsis |
| 9.45-10.20 | Frank Lowy
(Albert Einstein College of Medicine, New York, USA) | Host cellular and staphylococcal gene expression in a murine
model of wound infection |
| 10.20-10.40 | | Discussion |
| 10.40-11.00 | | Coffee |
| 11.00-11.35 | Philippe Moreillon
(Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) | Study of Staphylococcus aureus pathogenic factors by gene transfer into less pathogenic bacteria: consequence for infectivity in experimental endocarditis |
| 11.35-12.10 | Jan-Ingmar Flock
(Karolinska Institute, Huddinge, Sweden) | S. aureus endocarditis secondary to septic arthritis in the rat; applications of a modified model |
| 12.10-12.30 | | Discussion and General Discussion |
| Tuesday 11th May 17.30-19.30 |
| Session 5: Vaccines |
| 17.30-17.40 | Discussion Leader:
Jerry Pier
(Harvard Medical School, Boston, USA) | |
| 17.40-18.20 | Jean Lee
(Harvard Medical School, Boston, USA) | Protective efficacy of type 5 and 8 capsular polysaccharides in animal models of S. aureus infection |
| 18.20-18.35 | | Discussion |
| 18.35-19.15 | Naomi Balaban
(University of California, Davis, USA) | Autoinducer of virulence as a target for vaccine development against S. aureus |
| 19.15-19.30 | | Discussion |
| 20.30-22.00 | Poster Session 2 |
| Wednesday 12th May 9.00-12.30 |
| Session 6: Antibiotic Resistance |
| 9.00-9.10 | Discussion Leader:
Ron Skurray
(University of Sydney, Australia) | |
| 9.10-9.50 | Gordon Archer
(Virginia Commonwealth University, Richmond, VA, USA) | Transcriptional regulation of mecA and its role in the phenotypic expression of methicillin resistance |
| 9.50-10.05 | | Discussion |
| 10.05-10.45 | Brigitte Berger-Bacchi
(University of Zurich, Switzerland) | FemAB-like factors in staphylococcal peptidoglycan biosynthesis |
| 10.45-11.00 | | Discussion |
| 11.00-11.20 | | Coffee |
| 11.20-12.00 | Krzysztof Sieradzki
(Rockefeller University, New York, USA) | Biochemical and genetic aspects of the staphylococcal resistance to glycopeptides |
| 12.00-12.30 | | Discussion and General Discussion |
| Wednesday 12th May 17.30-19.30 |
| Session 7: Autolysins and their structure |
| 17.30-17.40 | Discussion Leader:
Fritz Goetz
(University of Tuebingen, Germany) | |
| 17.40-18.20 | Ken Bayles
(University of Idaho, Moscow, Id, USA) | Global regulation of staphylococcal autolysis |
| 18.20-18.35 | | Discussion |
| 18.35-19.15 | M. Sugai
(University of Hiroshima, Japan) | A major autolysin (Atl) of Staphylococcus aureus |
| 19.15-19.30 | | Discussion |
| 19.30- | | Business meeting |
| 20.30-22.00 | Poster Session 3 |
| Thursday 13th May 9.00-12.30 |
| Session 8: General regulators |
| 9.00-9.10 | Discussion Leader:
Staffan Arvidson
(Karolinska Institute, Stockholm, Sweden) | |
| 9.10-9.50 | Ambrose Cheung
(Rockefeller University, New York, USA) | SarA, a DNA binding protein, activates thr transcription of agr |
| 9.50-10.05 | | Discussion |
| 10.05-10.45 | Richard Novick
(Skirball Institute, NYU Medical Center, New York, USA) | Agr autoinduction and interference by cyclic peptides |
| 10.45-11.00 | | Discussion |
| 11.00-11.20 | | Coffee |
| 11.20-12.00 | Markus Bischoff
(University of Zurich, Switzerland) | sigB in Staphylococcus aureus |
| 12.00-12.30 | | Discussion and General Discussion |
| Thursday 13th May 17.30-19.30 |
| Session 9: Oral presentation of selected posters |
| Selector and Leader:
Henry Chambers (University of California, San Francisco, USA) |
