Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: What Lessons Can We Learn from Other Bacteria? |
| Discussion Leaders: Emma Johnson (University of Sheffield, United Kingdom) and Andras Spaan (University Medical Center Utrecht, The Netherlands) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:15 pm | Nassos Typas (European Molecular Biology Laboratory, Germany) "Reverse Chemical Genomics Fuel Biological Mechanism Discovery" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Jan-Willem Veening (University of Groningen, The Netherlands) "Streptococcus pneumoniae - Issues of Life and Death" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Lauren Popov (Stanford University School of Medicine, USA) "The Adherens Junctions Control Susceptibility to Staphylococcus aureus Alpha-Toxin Virulence" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Offensive
Action: Staphylococcal Toxins |
| Discussion Leader: Francois Vandenesch (INSERM U1111, France) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Victor Torres (New York University School of Medicine, USA) "Bi-Component Leukotoxins: More than Just Neutrophil Killers" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Michael Otto (National Institute of Allergy and Infectious Diseases, USA) "How a Pathogen Made Aggressive Toxins Out of a Simple Structure and Why It's Sometimes Good to Make Them, and Sometimes Not?" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:40 am | Thomas Henry (INSERM, France) "Leukocidins: What Can We Learn from the Identification of Host Receptors?" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | John McCormick (University of Western Ontario, Canada) "Staphylococcal Superantigens at the Commensal-Pathogen Interface" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tyler Scherr (University of Nebraska Medical Center, USA) "Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Is There Anything to Be Learnt from Animal
Models? |
| Discussion Leader: Arnold Bayer (University of California, Los Angeles School of Medicine / Los Angeles Biomedical Research Institute, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:40 pm | Steve Renshaw (University of Sheffield, United Kingdom) "Zebrafish Models of Staphylococcal Pathogenesis: Seeing Is Believing" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:25 pm | Christopher Weidenmaier (Institute for Micro- and Information Technology, Germany) "Animal Models for S. aureus Nasal Volonization: Mouse vs. Cotton Rat" |
7:25 pm - 7:40 pm | Discussion |
7:40 pm - 7:55 pm | Tao Jin (Gothenburg University, Sweden) "Different Susceptibiliyy of Mice Receiving Anti-TNF or CTLA4-Ig Treatments to Staphylococcal Septic Arthritis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Defensive
Action: Interaction with the Immune System |
| Discussion Leader: Suzan Rooijakkers (University Medical Center Utrecht, The Netherlands) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Wolfgang Weninger (Centenary Institute for Cancer Medicine and Cell Biology, Australia) "Mechanisms of Alpha-Hemolysin Mediated Immuno-Evasion by S. aureus In Vivo" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Rachel McLoughlin (Trinity College Dublin, Ireland) "Translational Studies Identify Specific T-Cell Subsets that Confer Protective Immunity During S. aureus Infection" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:40 am | Jean Pieters (University of Basel, Switzerland) "Deciphering the Signaling Pathways Regulating Host Immunity Against Intracellular Pathogens: Maintaining the Balance" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Simon Clarke (University of Reading, United Kingdom) "Modulation of Platelet Signalling by the Stapylococcus aureus Extracellular Milieu" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Andy Weiss (University of South Florida, USA) "Influence of the Small RNAP Subunits on Staphylococcus aureus Promoter Selectivity and Virulence" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | The Lifecycle: Growth and Division |
| Discussion Leader: Angelika Grundling (Imperial College London, United Kingdom) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:40 pm | Mariana Pinho (Instituto de Tecnologia Quimica e Biologica, Portugal) "Dynamics of the Cell Wall Sacculus During the Cell Cycle of Staphylococci" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:25 pm | Daniel Lopez (National Centre for Biotechnology (CNB), Spain) "Structural and Functional Characterization of Lipid Rafts in S. aureus" |
7:25 pm - 7:40 pm | Discussion |
7:40 pm - 7:55 pm | Rebecca Corrigan (University of Sheffield, United Kingdom) "Crosstalk Between Two Nucleotide-Signaling Pathways in Staphylococcus aureus" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Translational
Aspects of Staphylococcal Diseases |
| Discussion Leader: Lloyd Miller (Johns Hopkins University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Issac Chiu (Harvard University, USA) "Understanding the Role of Pain in Bacterial Host Defense and Inflammation" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Gabriel Nunez (University of Michigan Medical School, USA) "The Link Between Staphylococcus aureus and Allergic Skin Disease" |
10:25 am - 10:40 am | Discussion |
10:40 am - 11:10 am | Coffee Break |
11:10 am - 11:40 am | Jay Kolls (University of Pittsburgh School of Medicine, USA) "STAT3 Mediated Control of S. aureus" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Inge Herrmann (Swiss Federal Laboratories for Materials Science Technology, Switzerland) "New Approaches for Sepsis Diagnosis and Therapy: The Era of Microvesicles and Nanoparticles" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Derek Moormeier (University of Nebraska Medical Center, USA) "Temporal and Stochastic Control of Staphylococcus aureus Biofilm Development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Imaging Pathogenesis |
| Discussion Leader: Dominique Missiakas (University of Chicago, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:40 pm | James McNamara (University of Iowa, USA) "S. aureus Infection Imaging with Nuclease-Activated Molecular Probes" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:25 pm | Gootizen van Dam (University of Groningen, The Netherlands) "Molecular Imaging of Bacterial Infections: Right Time, Right Moment - Clinical Translatable Options" |
7:25 pm - 7:40 pm | Discussion |
7:40 pm - 7:55 pm | David Heinrichs (University of Western Ontario, Canada) "Imaging the S. aureus-Macrophage Interaction" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Antibiotics – The End of the Golden Era? |
| Discussion Leader: Steven Projan (MedImmune, USA) |
9:00 am - 9:15 am | Introduction by Discussion Leader |
9:15 am - 9:45 am | Dominique Monnet (European Centre for Disease Prevention and Control, Sweden) "Recent Resistance Trends, the Need to Define Rules for the Use of Novel Antibiotics" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Hanne Ingmer (University of Copenhagen, Denmark) "Transient and Inducible Resistance to Antimicrobials in S. aureus" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:35 am | Brian Conlon (Antimicrobial Discovery Center, USA) "Mutation of clpP Results in Reduced Persister Formation in Staph" |
10:35 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Eszter Nagy (Arsanis Biosciences GMBH, Austria) "Infectious Disease Antibodies - What Are the Expectations for Antibiotic Resistant and Susceptible Bacteria?" |
11:30 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Jean Lee (Brigham and Women's Hospital, USA) "Preclinical Efficiacy of ClfA in Prevention of S. aureus Infection" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Dominique Missiakas (University of Chicago, USA) "Antibodies Against Secreted Coagulase Trigger Phagocytic Killing of S. aureus" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Late-Breaking Topics / Selected Poster Presentations |
| Discussion Leaders: Eric Skaar (Vanderbilt University, USA) and Tammy Kielian (University of Nebraska Medical Center, USA) |
6:00 pm - 6:10 pm | Neal Hammer (Vanderbilt University School of Medicine, USA) "Metabolite Exchange Promotes Virulence of Antibiotic-Resistant Staphylococcus aureus" |
6:10 pm - 6:15 pm | Discussion |
6:15 pm - 6:25 pm | Meghan Verstraete (University of British Columbia, Canada) "A Link Between Heme and Siderophore Iron Uptake in Staphylococcus aureus" |
6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Maite Villanueva (Universite de Geneve, Switzerland) "Sensory Deprivation in Staphylococcus aureus" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 6:55 pm | Dane Parker (Columbia University, USA) "Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia" |
6:55 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Melissa Martin (Harvard Medical School, USA) "Identification of Cellular Factors that Contribute to Setting the MIC of Antibiotics for Staphylococcus aureus" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Claire Morvan (INRA, France) "Staphylococcus aureus fabD Mutants Bypass Fatty Acid Synthesis Inhibitors by Incorporating Exogenous Fatty Acids" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:40 pm | Tyler Broussard (St. Jude Children's Research Hospital, USA) "Structural Elements Required for Fatty Acid Kinase to Regulate Virulence Factor Transcription in Staphylococcus aureus" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:00 pm | Closing Remarks |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |