Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Unique Approaches for
Combating Staphylococcal Infections
Discussion Leader: Anthony Lynch (Janssen Research & Development, LLC, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Wouter Hazenbos (Genentech, Inc., USA)
"Therapeutic Targeting of Staphylococcus aureus by an Antibody-Antibiotic Conjugate"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Bret Sellman (MedImmune, LLC, USA)
"Monoclonal Antibody-Mediated Toxin Neutralization Promotes a Protective Immune Response"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Paul Dunman (University of Rochester, USA)
"Targeting the GIANTS - Gram-Positive Indispensable Accessories of Bacterial Nucleic Acid Metabolism and Translational Systems"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism: Fueling the Way
Discussion Leader: Jeff Boyd (Rutgers, the State University of New Jersey, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Vinai Thomas (University of Nebraska Medical Center , USA)
"Metabolic Control of Regulated Cell Death in Staphylococcus aureus "
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Anthony Richardson (University of Pittsburgh, USA)
"Glucose Import and Nitric Oxide Resistance in Staphylococcus aureus "
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:05 am
Kelly Rice (University of Florida, USA)
"Contributions of Bacterial Nitric Oxide Synthase to Staphylococcus aureus Metabolism"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Neal Hammer (Michigan State University, USA)
"IspA Supports Small Colony Development by Alleviating Oxidative Stress"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Shaun Brinsmade (Georgetown University, USA)
"CodY Mediated Repression of the Sae Two-Component System in Staphylococcus aureus "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
McKenzie Lehman (University of Nebraska Medical Center, USA)
"Amino Acid Metabolism Is Important During a Staphylococcus aureus Skin Abscess Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jean Lee (Brigham and Women's Hospital / Harvard Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Staphylococcal Virulence
Determinants
Discussion Leader: Jean Lee (Brigham and Women's Hospital / Harvard Medical School, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
James O'Gara (NUI Galway, Ireland)
"Using an Amino Acid Analog to Resensitise MRSA to Beta-Lactam Antibiotics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Ruth Massey (University of Bristol, United Kingdom)
"What Can Genome Sequencing Tell Us About Staphylococcal Pathogenicity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Jose Penades (University of Glasgow, United Kingdom)
"The Right Move"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host vs. Staphylococci: The Battle Continues
Discussion Leader: Juliane Bubeck Wardenburg (Washington University in St. Louis, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Jim Cassat (Vanderbilt University Medical Center, USA)
"Staphylococcal Metabolism and Virulence During Osteomyelitis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Olaf Schneewind (University of Chicago, USA)
"Staphylococcus aureus Manipulation of B Cell Responses During Infection"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Mary O'Riordan (University of Michigan Medical School, USA)
"A Mitochondrial Sirtuin Protects Phagocytes from Oxidative Destruction During MRSA Infection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Anna Norrby-Teglund (Karolinska Institute, Sweden)
"Severe S. aureus Infections of Human Lung and Skin: Determinants of Tissue Pathology"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Andras Spaan (University Medical Center Utrecht, The Netherlands)
"Identification of the First F-Component Specific Leukocidin Receptor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Rob van Dalen (University Medical Center Utrecht, The Netherlands)
"The C-Type Lectin Receptor Langerin on Skin Langerhans Cells Interacts with Wall Teichoic Acid of Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Staphylococcal
Interactions with Other Bacterial Species
Discussion Leader: Joan Geoghegan (Trinity College Dublin, Ireland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Marvin Whiteley (University of Texas at Austin, USA)
"Co-Infecting Microbes Impact the S. aureus Essential Genome"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Kimberly Kline (Nanyang Technological University, Singapore)
"Enterococcus faecalis -Staphylococcus aureus Interactions During Wound Infection"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Amanda Oglesby-Sherrouse (University of Maryland, Baltimore, USA)
"Impacts of Iron on Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa "
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Evasive
Strategies of Staphylococci
Discussion Leader: Marisa Gomez (University of Buenos Aires, Argentina)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
George Liu (Cedars-Sinai Medical Center, USA)
"Host Immune Response to S. aureus Peptidoglycan"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Francis Alonzo (Loyola University Chicago, USA)
"Intersections of Metabolism and Host Immunity: A Staphylococcus aureus Metabolic Cofactor that Suppresses Inflammation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Alice Prince (Columbia University, USA)
"Metabolic Stress Contributes to the Pathogenesis of S. aureus Infection"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Joaquin Madrenas (Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, USA)
"Disease Tolerance to S. aureus Infection"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Tiffany Scharschmidt (University of California, San Francisco, USA)
"Early Priming to Staphylococcal Antigens Sets the Course for Host Immune Tolerance vs. Immunity"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Emma Boldock (University of Sheffield, United Kingdom)
"Human Commensals Augment Bacterial Pathogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulation
Discussion Leader: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Kim Lewis (Northeastern University, USA)
"Persisters in S. aureus "
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Alexander Horswill (University of Colorado, USA)
"Regulation of Clumping and Virulence in Staphylococcus aureus "
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Angelika Grundling (Imperial College London, United Kingdom)
"Regulation of Cyclic-di-AMP Synthesis in Staphylococcus aureus – What Makes, Breaks and Triggers Its Production"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Staphylococcal
Infections and Clinical Considerations
Discussion Leader: Jessica Snowden (University of Nebraska Medical Center, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Paul Kubes (University of Calgary, Canada)
"Imaging the Interplay Between S. aureus and Innate Immunity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Bo Shopsin (New York Universtity School of Medicine, USA)
"Adaptation of S. aureus to the Host and Hospital Environment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Keisuke (Chris) Nagao (National Institutes of Health, USA)
"Homeostatic Regulation of the Skin Microbiota by Host Immunity"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Juliane Bubeck Wardenburg (Washington University in St. Louis, USA)
"Staphylococcus aureus : What Will It Take to Modify Disease?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Barbara Kahl (University Hospital Muenster, Germany)
"The Role of Superoxide Dismutase During Chronic Airway Infection of Cystic Fibrosis Patients"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kayan Tam (New York University School of Medicine, USA)
"Fighting Toxins with Toxins - Exploiting the Leukocidins as Potential Targets for Anti-Staphylococcus aureus Vaccine"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Late-Breaking Topics
Discussion Leaders: Andreas Peschel (University of Tubingen, Germany) and Ross Fitzgerald (University of Edinburgh, United Kingdom)
5:30 pm - 5:40 pm
Sarah Baines (University of Melbourne, Australia)
"Convergent Adaptation of qacA -Containing Plasmids"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Ronan Carroll (Ohio University, USA)
"Contribution of Peptidyl-Prolyl Cis/Trans Isomerases to Virulence Factor Secretion"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Samantha Genardi (Northwestern University, USA)
"The Role of NKT Cells in Systemic MRSA Resistant Infections"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Ron Flannagan (University of Western Ontario, Canada)
"Mechanisms by Which MRSA Replicate Within Macrophage Phagolysosomes"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Masanori Matsumoto (University of Michigan, USA)
"S. aureus PSMa Peptides Induce Keratinocyte Alarmin Release"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Holger Rohde (University Hospital Hamburg-Eppendorf, Germany)
"The Small Basic Protein (Sbp): Structure and Function in S. epidermidis Biofilm Formation"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Yingjie Lu (Boston Children's Hospital, USA)
"A Multiple Antigen Presenting System Vaccine Induces Protective B- and T Cell Immunity"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Joan Geoghegan (Trinity College Dublin, Ireland)
"Adherence of S. aureus to Skin in Atopic Dermatitis"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure