SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: Catriona Jamieson, MD, PhD (UCSD) |
7:40 pm - 7:50 pm | Introduction |
7:50 pm - 8:05 pm | Andreas Trumpp, PhD (DKFZ) "Dormancy in normal and malignant stem cells" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 9:15 pm | Keynote Lecture: John Dick, PhD (UHN) "Modeling the human leukemogenic process" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Self-Renewal and Cancer |
| Discussion Leader: Tannistha Reya, PhD (Duke) |
9:00 am - 9:10 am | Introduction |
9:10 am - 9:45 am | Hanna Mikkola, MD, PhD (UCLA) "Specification and self-renewal of hematopoietic stem cells" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 11:10 am | Tannistha Reya, PhD (Duke) "Developmental Signaling in Stem Cells and Cancer" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Roel Nusse, PhD (Stanford) "Wnt signaling in tissue generation and regeneration" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hemapoietic Stem Cells and Leukemia |
| Discussion Leader: Camilla Forberg, PhD (UCSC) |
7:30 pm - 7:40 pm | Introduction |
7:40 pm - 8:10 pm | Ioannis Aifantis, PhD (NYU) "The Ubiquitome and its role in blood stem cell differentiation and leukemia" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | David Traver, PhD (UCSD) "Development of the hematopoietic system" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Emmanuelle Passegue, PhD (UCSF) "HSC function in normal and diseased hematopoiesis" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Reprogramming and Cancer |
| Discussion Leader: Jean C.Y. Wang, PhD (U Toronto) |
9:00 am - 9:10 am | Introduction |
9:10 am - 9:50 am | Robert Wechsler-Reya, PhD (Duke) "The Road to Ruin: Transforming Stem Cells into Brain Tumors" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Tom Look, MD (Harvard) "MET activation in leukemia initiating cells induced by aberrant autocrine expression" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Maarten Van Lohuizen, PhD (Netherlands Cancer Institute) "Role of Polycomb repressors in stem cells and cancer" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Solid Tissue Stem Cells and Cancer |
| Discussion Leader: Irv Weissman, MD (Stanford) |
7:30 pm - 7:40 pm | Introduction |
7:40 pm - 8:10 pm | Irv Weissman, MD (Stanford) "Normal and neoplastic stem cells" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Hong Wu, PhD (UCLA) "PTEN, Stem Cells and Prostate Cancer Stem Cells" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jane Visvader, MD (Walter + Eliza Hall Institute of Medical Research) "The mammary epithelial hierarchy and its implications for oncogenesis" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cell Profiling and (Epi)genomics |
| Discussion Leader: Bing Ren, PhD (UCSD) |
9:00 am - 9:10 am | Introduction |
9:10 am - 9:35 am | Connie Eaves, PhD (BC Cancer Agency, Terry Fox Laboratory, Vancouver) "Manipulating CML Stem Cell Self-renewal" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Kelly Frazer, PhD (UCSD) |
10:10 am am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:55 am - 11:20 am | Alysson Muotri (UCSD) "Mobilization of L1 retrotransposons during stem cell differentiation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Leonard Zon, MD (Harvard) "Stem Cell Fate and Self-Renewal" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Late Breaking Abstracts |
| Discussion Leader: Barbara Marte, PhD (Nature Journal) |
7:30 pm - 7:40 pm | Introduction |
7:40 pm - 8:10 pm | Bill Matsui, PhD (Johns Hopkins) "Pancreatic cancer stem cell targeting via the tumor microenvironment" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Peter Dirks, PhD (U Toronto) |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Alan Trounson, PhD (CIRM) "Accelerating translation of discoveries in cancer stem cell related research to the clinic" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Niche Signaling and Stem Cell Control |
| Discussion Leader: Lawrence Goldstein |
9:00 am - 9:10 am | Introduction |
9:10 am - 9:50 am | Hans Clevers, MD, PhD (Hubrecht Institute) "Wnt signaling, Lgr5 stem cells and cancer" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Toshio Suda, MD, PhD (Keio U) "Quiescence of stem cells in the hypoxic niche" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Amy Wagers, PhD (Harvard) "Myogenic and mesenchymal precursors in muscle regeneration, aging, and tumorigenesis" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Therapeutics Against Cancer Stem Cells |
| Discussion Leader: Neil Gibson, PhD (Pfizer) |
7:30 pm - 7:40 pm | Introduction |
7:40 pm - 8:10 pm | Craig Jordan, PhD (Rochester) "Therapeutic Targeting of Leukemia Stem Cells" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Dennis Carson, MD (UCSD) "Application of Cancer Stem Cells in Drug Development" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jeremy Rich, MD (Lerner Research Institute) "Brain Tumor Stem Cells in Therapy" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |