Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Stem Cells in Cancer Initiation and Relapse
Discussion Leader: Yejing Ge (Rockefeller University, USA)
3:15 pm - 3:50 pm
Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Stem Cells in Cancer Initiation and Relapse"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Investigating Signals Driving Normal and
Malignant Growth
Discussion Leader: Toni Celia-Terrasa (Princeton University, USA)
5:30 pm - 5:40 pm
Reyhan Akhtar (Monash University, Australia)
"SNAI1 Expression Correlates with Intestinal Stem Cell Markers in Colorectal Cancer"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Lyndsay Murrow (University of California, San Francisco, USA)
"Reconstituting the Mammary Stem Cell Niche"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Zhiyang Chen (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"Cohesin Deficiency-Induced Differentiation Defect Contributes to Clonal Expansion in Hematopoietic Stem Cells During Aging"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Sejal Vyas (Harvard Medical School, USA)
"SIRT4 Regulation of Intestinal Homeostasis upon DNA Damage"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Nikki Lytle (University of California, San Diego, USA)
"Stem Cell Signals Drive Pancreatic Cancer Therapy Resistance"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Simon Schworer (Leibniz Institute on Aging (FLI), Germany)
"Epigenetic Stress Responses Induce Muscle Stem-Cell Aging by Hoxa9 Developmental Signal"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Theodore Ho (University of California, San Francisco, USA)
"Autophagy Maintains the Metabolism and Function of Young and Old Hematopoietic Stem Cells"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Georg Sedlmeier (Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg, Germany)
"Matrix-Assisted Autocrine BMP Signalling Regulates Stemness Properties in Melanoma Cells Through Induction of Id1 and Id3 Expression"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cancer Stem Cell Biology
Discussion Leader: Mark Esposito (Princeton University, USA)
9:00 am - 9:10 am
Toni Celia-Terrasa (Princeton University, USA)
"The miR-199a Pathway Mediates the Evasion of Normal and Cancer Stem Cells from Interferon-Imposed Constraint"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Jessie Brown (New York University School of Medicine, USA)
"Defining
Cellular Quiescence as a Multi-Drug Resistance Mechanism in Squamous Cell Carcinoma"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Yejing Ge (Rockefeller University, USA)
"At the Crossroads of Wound-Repair and Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Kihyun Lee (Memorial Sloan Kettering Cancer Center, USA)
"Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Scott Callahan (Memorial Sloan Kettering Cancer Center, USA)
"Cell of Origin Studies of Malignant Melanoma Using both Transgenic Zebrafish and Human Pluripotent Stem Cell-Derived Melanocytes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kyle Spinler (University of California, San Diego, USA)
"Identifying Elements of the Msi2 Network Provides a New Therapeutic Window into Controlling Blast Crisis Chronic Myelogenous Leukemia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Alastair Davies (University of British Columbia, Canada)
"EZH2 Reprogramming Confers Intrinsic Stem Cell Properties and Developmental Plasticity Driving Neuroendocrine Prostate Cancer"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Mithil Soni (University of South Carolina, USA)
"Multifaceted microRNA-489 Inhibits Autophagy and Cancer Stem Cell Population in Breast Cancer and Sensitizes Breast Cancer Cells to Doxorubicin"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Exploring Diverse Career Options Post-Training
Discussion Leader: Lyndsay Murrow (University of California, San Francisco, USA)
1:30 pm - 2:30 pm
Panel Discussion
Career Options Post-Training
Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
Amy Wagers (Harvard University, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes