Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Cell Fate Decisions in the Biology of Stem Cells and Cancer
Discussion Leader: Albert Almada (Harvard University, USA)
3:45 pm - 4:20 pm
Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
"Cell Fate Decisions in the Biology of Stem Cells and Cancer"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lineage Relationships and Cell Plasticity / New Roles for Niches
Discussion Leader: Christie Rodriguez-Ramirez (University of Michigan School of Dentistry, USA)
7:30 pm - 7:40 pm
Victoria Wang (The Francis Crick Institute, United Kingdom)
"CD9 Identifies Pancreatic Cancer Stem Cells and Modulates Glutamine Metabolism to Fuel Tumour Growth"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Ayesh Seneviratne (University of Toronto, Canada)
"The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness and Differentiation by Modulating Intracellular Levels of Phospholipids"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Ananya Pal (National University of Singapore, Singapore)
"G9a-Wnt Axis Mediates Differentiation Block in Embryonal Rhabdomyosarcoma"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Alastair Davies (Vancouver Prostate Centre, Canada)
"Identity Fraud: Lineage Plasticity as a Mechanism of Anti-Androgen Resistance and Target for Therapy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Yejing Ge (University of Texas MD Anderson Cancer Center, USA)
"Functional Interrogation of Stem Cell Lineage Infidelity in Cancer, Wound Repair and Aging"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Kana Tominaga (National Cancer Center Research Institute, Japan)
"Semaphorin Signaling via MICAL3 Induces Symmetric Cell Division to Expand Breast Cancer Stem-Like Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Meryem Gonzalez Celeiro (Harvard University, USA)
"Sympathetic Nerves and Arrector Pili Muscles Form a Dual Component Niche to Regulate Hair Follicle Stem Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shiri Gur-Cohen (Rockefeller University, USA)
"A Stem Cell-Driven Lymphoangiogenic Switch Coordinates Tissue Regeneration"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Single-Cell Approaches to Study Development and Disease / Insights for Therapeutics
Discussion Leader: Erin Nekritz (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:10 am
Fabiana Duarte (Harvard University, USA)
"Single-Cell Epigenomics Reveals Cell Type Specific and Stimulation-Responsive Regulatory Factors Across the Human Hematopoietic Continuum"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Ankur Sharma (Genome Institute of Singapore, A*STAR, Singapore)
"Single-Cell Genomics Reveals Divergent Modes of Drug-Induced Tumor Evolution"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Tugba Topal (University of Michigan, USA)
"Integrin-Targeted Cyclic Forces Accelerate Neural Tube-Like Rosette Formation from Human Embryonic Stem Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
G. Kenneth Gray (Harvard Medical School, USA)
"Characterization of Murine Mammary Epithelial Populations Throughout Development and in Premalignant Tissue via Mass Cytometry"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Stefanie Tiede (University of Basel, Switzerland)
"Tumor Heterogeneity During the Progression of Metastatic Breast Cancer"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Laura Medrano Gonzalez (Queen Mary University of London, United Kingdom)
"Class I PI3Ka Isoform Regulates NOD1/2 Mediated Bacterial Amino Acid Sensing Pathway and Control Gut Homeostasis Under Inflammatory Conditions"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Megan Insco (Dana-Farber Cancer Institute / Boston Children's Hospital, USA)
"CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Jay Sarthy (Fred Hutchinson Cancer Research Center, USA)
"H3 Variants Shape Chromatin Landscapes and Response to Therapy in H3-Mutant Diffuse Midline Gliomas"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Making an Impact
Exploring the real-world impact of your research.
Discussion Leader: Jill Goldstein (Harvard University, USA)
1:30 pm - 2:30 pm
Panel Discussion
Making an Impact
Leanne Jones (University of California, Los Angeles, USA)
Shahragim Tajbakhsh (Institut Pasteur, France)
Amy Wagers (Harvard University, USA)
Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
