Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Stochasticity Across Spatial-Temporal Scales |
| Our opening speakers will highlight their research across the main organizing themes of this conference: networks, cells, development and evolution. |
| Discussion Leader: Ken Dill (Stony Brook University, USA) |
7:40 pm - 8:10 pm | Hong Qian (University of Washington, USA) "Foundations for Stochastic Dynamical Descriptions of Living Processes" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Marc Kirschner (Harvard Medical School, USA) "The Origin of Specificity in Regulated Protein Degradation" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Laura Lavine (Washington State University, USA) "Condition-Dependent Growth and Development of the Exaggerated Weapons of Sexual Selection" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stochasticity in Disease and Cell Fate Networks |
| Discussion Leader: Roy Wollman (University of California, San Diego, USA) |
9:00 am - 9:30 am | Jin Wang (Stony Brook University, USA) "Regulatory Networks Underlying Cancer and Stem Cells" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Tanja Kortemme (University of California, San Francisco, USA) "Prediction and Design of Protein-Protein Interactions and Dynamics" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Hao Li (University of California, San Francisco, USA) "Physical Principles of Aging, Cancer and Death" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Sunney Xie (Harvard University, USA) "Single-Cell Cancer Genomes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stochasticity in Signaling Networks |
| Discussion Leader: Leor Weinberger (University of California, San Francisco, USA) |
7:30 pm - 7:35 pm | Selected from Poster Abstracts: Alistair Boettiger (Harvard University, USA) "Super-Resolution Imaging of Chromatin Nano-Structure Reveals Principles of Genome Folding" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:45 pm | Selected from Poster Abstracts: Kevin Thurley (University of California, San Francisco, USA) "Building Population-Level Response Curves from Individual Cell Ca+2 Interspike Intervals" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 7:55 pm | Selected from Poster Abstracts: Maryam Aliee (Ecole Normale Superieure de Lyon, France) "A Stochastic Model for a Gene Regulatory Network Involved in Plant Morphogenesis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:30 pm | Andre Levchenko (Yale University, USA) "Noise and Information in Signaling Networks" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Long Cai (California Institute of Technology, USA) "Single Cell Analysis by Sequential FISH" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Stochasticity in Cellular Organization |
| Discussion Leader: Nathalie Balaban (Hebrew University, Israel) |
9:00 am - 9:30 am | Daniel Needleman (Harvard University, USA) "Stochasticity in Spindle Assembly" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Roy Wollman (University of California, San Diego, USA) "Accurate Information Transmission Through Dynamic Biochemical Signaling Networks" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Wallace Marshall (University of California, San Francisco, USA) "Biological Noise in the Flagellar Length Control System" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Alexander Mogilner (New York University, USA) "Effects of Noise in Actomyosin Contractility" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Principles and Consequences of Cellular Heterogeneity |
| Discussion Leader: Vito Quaranta (Vanderbilt University School of Medicine, USA) |
7:30 pm - 7:35 pm | Selected from Poster Abstracts: Leonard Harris (Vanderbilt University School of Medicine, USA) "Intrinsic Stochasticity and Heterogeneous Drug Response in Cancer Cell Populations" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:45 pm | Selected from Poster Abstracts: Shicong Xie (Massachusetts Institute of Technology, USA) "Interactions Between Contractile Events During Tissue Folding" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 7:55 pm | Selected from Poster Abstracts: Franck Raynaud (Ecole Polytechnique Federale de Lausanne, Switzerland) "Shape-Motion Feedback in Rapidly Migrating Cells" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:30 pm | Lani Wu (University of California, San Francisco, USA) "Heterogeneity of Drug Resistance in Cancer" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Nathalie Balaban (Hebrew University, Israel) "Understanding the Variability of Growth in Single Cells" |
9:15 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heterogeneity in Tissue Development and Homeostasis |
| Discussion Leader: Thomas Gregor (Princeton University, USA) |
9:00 am - 9:30 am | Leor Weinberger (University of California, San Francisco, USA) "Harnessing Noise for Therapy" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Boris Shraiman (Kavli Institute for Theoretical Physics, USA) "Patterning and Growth in Development" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Stanislav Shvartsman (Princeton University, USA) "Modeling Pattern Formation and Morphogenesis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Allon Klein (Harvard Medical School, USA) "Statistical Physics, Homeostasis and Cancer in Colon Tissue" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Stochasticity in Pattern Formation of Developing Tissues |
| Discussion Leader: Zev Gartner (University of California, San Francisco, USA) |
7:30 pm - 7:35 pm | Selected from Poster Abstracts: Samuel Skinner (Baylor College of Medicine, USA) "Single-Cell Analysis of Transcription Kinetics Across the Cell Cycle" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:45 pm | Selected from Poster Abstracts: Jacqueline Humphries (University of California, San Diego, USA) "Population Dynamics Give Rise to Emergent Oscillations in Biofilm Growth" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 7:55 pm | Selected from Poster Abstracts: Orit Peleg (Harvard University, USA) "Optimal Intermittent Reorientation in Insect Navigation" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:30 pm | Claude Desplan (New York University, USA) "Stochastic vs. Deterministic Choices in the Visual System" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Thomas Gregor (Princeton University, USA) "From Stochastic Transcription to Precise Expression Patterns in the Developing Embryo" |
9:15 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Evolution of Emergent Behaviors in Heterogeneous Cellular Populations |
| Discussion Leader: Daniel Fisher (Stanford Unviersity, USA) |
9:00 am - 9:30 am | Gabor Balazsi (Stony Brook University, USA) "Newcomer Network Evolution: From Non-Genetic to Genetic Drug Resistance and Back Again" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Peter Robin Hiesinger (University of Texas Southwestern Medical Center, USA) "Brain Wiring Evolution on the Fly" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Deborah Gordon (Stanford University, USA) "The Ecology of Collective Behavior" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Oskar Hallatschek (University of California, Berkeley, USA) "The Role of Noise in the Evolution and Function of Microbial Colonies" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolutionary Design Principles and Dynamics of Genomes and Proteins |
| Discussion Leader: Marc Kirschner (Harvard Medical School, USA) |
7:30 pm - 7:35 pm | Selected from Poster Abstracts: Taraneh Zarin (University of Toronto, Canada) "Phosphorylation Site Turnover in Disordered Regions: Exploring a Stabilizing Selection Hypothesis" |
7:35 pm - 7:40 pm | Discussion |
7:40 pm - 7:45 pm | Selected from Poster Abstracts: Lei Dai (Massachusetts Institute of Technology, USA) "Spatio-Temporal Dynamics Before Population Collapse" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 7:55 pm | Selected from Poster Abstracts: Morgan Delarue (University California, Berkeley, USA) "A Microfluidic Device
to Confine a Cell Population" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:30 pm | Michael Desai (Harvard University, USA) "Dynamics of Genomic Sequence Evolution in Experimental Populations" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Rama Ranganathan (University of Texas Southwestern Medical Center, USA) "The Evolutionary 'Design' of Proteins" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |