Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Statistical Mechanics in Molecular Biology
Discussion Leader: Wallace Marshall (University of California, San Francisco, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:25 pm
Rob Phillips (California Institute of Technology, USA)
"Demonic Biology"
8:25 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Jie Xiao (Johns Hopkins University School of Medicine, USA)
"Gene Regulation at the Single Molecule Level"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stochastic Dynamics of Biological Molecules and Networks
Discussion Leader: John Correia (University of Mississippi Medical Center, USA)
9:00 am - 9:30 am
Ao Ma (University of Illinois at Chicago, USA)
"A Structural Mechano-Chemical Model for Dynamic Instability of Microtubules"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Jin Wang (State University of New York at Stony Brook, USA)
"Nonequilibrium Dynamics and Thermodynamics in Cell Fate Decision Making"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
David Sivak (Simon Fraser University, Canada)
"Using a System's Equilibrium Behavior to Reduce Its Energy Dissipation in Non-Equilibrium Processes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Irina Gopich (National Institutes of Health, USA)
"Theory of Diffusion-Influenced Reaction Networks"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Elijah Roberts (Johns Hopkins University, USA)
"Mapping Epigenetic Landscapes Using Dynamic Perturbations"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Ping Wei (Center for Quantitative Biology, Peking University, China)
"Synthetic NF-kB: A Building Approach to Study Complex Signaling Behaviors"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Jennifer Ross (University of Massachusetts Amherst, USA) and Wallace Marshall (University of California, San Francisco, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single-Cell Biophysics: Measurement and Analysis
Discussion Leader: Jie Xiao (Johns Hopkins University School of Medicine, USA)
7:30 pm - 8:00 pm
Suliana Manley (École Polytechnique Fédérale de Lausanne, Switzerland)
"Stochasticity and Control in Mitochondrial Division"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Po-Yi Ho (Harvard University, USA)
"How Microbes Decide When to Divide: From Bacteria to Cyanobacteria"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Lanying Zeng (Texas A&M University, USA)
"Imaging Dynamic Subcellular Organization that Mediates Cell Fate"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Junhua Yuan (University of Science and Technology of China, China)
"Equilibrium and Nonequilibrium Dynamics in the Behavior of Bacterial Flagellar Motor"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Statistical Physics of Evolution and Disease
Discussion Leader: James Boedicker (University of Southern California, USA)
9:00 am - 9:30 am
Manuel Razo-Mejia (California Institute of Technology, USA)
"Does Evolution Care About Bits? Information as Currency in Nature's Stock Market"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Barbara Jones (IBM Research - Almaden, USA)
"Dynamics of Viral Mutation and Evolution"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Wenying Shou (Fred Hutchinson Cancer Research Center, USA)
"Artificial Selection of Microbial Communities"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Philippe Cluzel (Harvard University, USA)
"Codon-Programmable Noise in Gene Expression Dictates Cell-to-Cell Variability in Nutrient Poor Environments"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Self-Organization and Phase Transitions in Biological Systems
Discussion Leader: Yuhai Tu (IBM Thomas J. Watson Research Center, USA)
7:30 pm - 8:00 pm
Moumita Das (Rochester Institute of Technology, USA)
"Collective Behavior Underlying Mechanobiology of Cells and Tissues: Role of Criticality and Compositeness"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Margaret Johnson (Johns Hopkins University, USA)
"Modeling Nonequilibrium Self-Assembly in the Cell Through Reaction-Diffusion Simulation"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Wylie Ahmed (Description California State University, Fullerton, USA)
"Quantifying Nonequilibrium Fluctuations in Living Matter"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Arpita Upadhyaya (University of Maryland, USA)
"Arcs, Flows and Waves: Cytoskeletal Dynamics and Mechanosensing in Immune Cells"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell State Space Dynamics: Landscapes and Trajectories for Differentiation and Behavior
Discussion Leader: Jin Wang (State University of New York at Stony Brook, USA)
9:00 am - 9:30 am
Srividya Iyer-Biswas (Purdue University, USA)
"Emergent Simplicity in Stochastic Individual-Cell Dynamics"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Jianhua Xing (University of Pittsburgh, USA)
"Reconstructing Cell Dynamics from Single Cell Trajectories"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Arvind Murugan (University of Chicago, USA)
"Kalman-Like Self-Tuned Sensitivity in Biological Clocks"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Simone Pigolotti (Okinawa Institute of Science and Technology, Japan)
"Generic Properties of Stochastic Entropy Production"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Stochastic Physics of the Central Dogma
Discussion Leader: Arpita Upadhyaya (University of Maryland, USA)
7:30 pm - 8:00 pm
Jane Kondev (Brandeis University, USA)
"Long Range Communication in the Nucleus"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Wenjun Xie (Massachusetts Institute of Technology, USA)
"Mechanism of Chromatin Domain Formation Revealed by Epigenetic Energy Landscape"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Luis Aguilera (Colorado State University, USA)
"Stochastic Modeling of Single RNA Translation Dynamics"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Christoph Zechner (Max Planck Institute of Molecular Cell Biology and Genetics / Center for Systems Biology Dresden, Germany)
"Buffering of Gene Expression Noise by Liquid Compartments"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
From Cells to Organisms: Stochastic Dynamics Across Biological Scales
Discussion Leader: Moumita Das (Rochester Institute of Technology, USA)
9:00 am - 9:30 am
Zachary Pincus (Washington University in St. Louis, USA)
"Persistent Gene Expression States Drive Lifespan Differences Among Otherwise-Identical C. elegans "
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Robert Johnston (Johns Hopkins University, USA)
"Stochastic Cell Fate Specification in Fly Eyes and Human Retinal Organoids"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Elena Koslover (University of California, San Diego, USA)
"Run, Wander and Drift: Interplay of Physical Mechanisms for Intracellular Transport"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Ertugrul Ozbudak (Cincinnati Children's Hospital Medical Center, USA)
"Dynamics of the Segmentation Clock"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fluctuations in Cellular and Subcellular Structure
Discussion Leader: Suliana Manley (École Polytechnique Fédérale de Lausanne, Switzerland)
7:30 pm - 8:00 pm
Jennifer Ross (University of Massachusetts Amherst, USA)
"Active Enzymes as Biological Active Matter"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Peter Foster (Massachusetts Institute of Technology, USA)
"Experimental Measurements of Dissipation and Efficiency in an Active Cytoskeletal Material"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Jason Wagoner (Stony Brook University, USA)
"The Biological Catch Bond Suppresses Fluctuations in Nonequilibrium Systems"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Iva Tolic (Ruder Boskovic Institute, Croatia)
"Forces and Torques in the Mitotic Spindle"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure