Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Machine Learning and Data Driven Analysis in Biology
Discussion Leader: Herbert Levine (Northeastern University, USA)
7:40 pm - 8:00 pm
Lei-Han Tang (Hong Kong Baptist University, Hong Kong SAR China)
"Harnessing Peak Transmission Around Symptom Onset for Non-Pharmaceutical Intervention and Containment of the COVID-19 Pandemic"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Andrea Liu (University of Pennsylvania, USA)
"Insight into Protein Allostery from Persistent Homology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Simone Bianco (IBM Almaden Research Center, USA)
"AI-Driven Design of Biological Systems"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Oded Regev (New York University, USA)
"Using Interpretable Machine Learning to Decipher the Determinants of Exon Inclusion"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nonequilibrium Physics in Active Living Systems
Discussion Leader: Cristina Marchetti (University of California, Santa Barbara, USA)
9:00 am - 9:25 am
Daniel Needleman (Harvard University, USA)
"Cytoskeletal Energetics and Energy Metabolism"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Michael Shelley (New York University, USA)
"Active Matter and Transport in Living Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Noah Mitchell (Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA)
"Active Folding via Bilayer Morphogenesis In Vivo "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Dapeng "Max" Bi (Northeastern University, USA)
"Shear-Driven Solidification and Nonlinear Elasticity in Epithelial Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Ken Dill (Stony Brook University, SUNY, USA)
"The Maximum Caliber Principle for Modeling Stochastic Dynamics"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Navish Wadhwa (Harvard University, USA)
"Stochastic Physics of Stator Assembly in the Bacterial Flagellar Motor"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Clare Yu (University of California, Irvine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Noise in Gene Expression and Cellular Systems
Discussion Leader: Robert Austin (Princeton University, USA)
7:30 pm - 7:50 pm
Michael Elowitz (California Institute of Technology, USA)
"Multicellular Circuit Design"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Naama Brenner (Technion - Israel Institute of Technology, Israel)
"Multiple Timescales in Bacterial Growth Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Suckjoon Jun (University of California, San Diego, USA)
"Bacterial Replication Initiation as a Tractable Problem for Deriving Principles of Precision Control in Biology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Xinyue Chen (Gladstone Institutes, USA)
"A DNA-Repair Pathway Controls Transcriptional Noise to Promote Cell-Fate Transitions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Alberto Sassi (IBM, USA)
"Protein Concentration Fluctuations in the High Expression Regime"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Information Processing in Neuroscience and Immunology
Discussion Leader: Sima Setayeshgar (Indiana University, USA)
9:00 am - 9:20 am
Dmitri Chklovskii (Simons Foundation, USA)
"The Search for Neural Computational Primitives"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nicolas Brunel (Duke University, USA)
"Online Learning in Networks of Neurons Constrained by Data"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Tatyana Sharpee (Salk Institute for Biological Studies, USA)
"Towards Lossless Transformation of Neural Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Shanshan Qin (Harvard University, USA)
"Dynamics of Drifting Receptive Fields During Noisy Representation Learning"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Shenshen Wang (University of California, Los Angeles, USA)
"Physical Constraints and Driving Forces of Adaptive Immunity"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Armita Nourmohammad (University of Washington, USA)
"Immune Memory Strategies in Light of Host-Pathogen Coevolution"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tal Einav (Fred Hutchinson Cancer Research Center, USA)
"Peering into the Antibody Repertoire: Functionally Characterizing Individual Antibodies Within Polyclonal Mixtures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stochastic Physics in Cancer Biology
Discussion Leader: Ken Dill (Stony Brook University, SUNY, USA)
7:30 pm - 7:50 pm
Herbert Levine (Northeastern University, USA)
"Epigenetic Effects on the Epithelial-Mesenchymal Transition"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Clare Yu (University of California, Irvine, USA)
"Physics Approaches to the Spatial Distribution of Immune Cells in Tumors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mingming Wu (Cornell University, USA)
"Roles of Tumor Microenvironment in Tumor Cell Heterogeneity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Robert Austin (Princeton University, USA)
"Non-Gaussian Statistics in Biological Systems"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Information Processing in Cellular Systems
Discussion Leader: Clare Yu (University of California, Irvine, USA)
9:00 am - 9:20 am
Chao Tang (Peking University, China)
"Scaling in Drosophila Embryogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sima Setayeshgar (Indiana University, USA)
"Dimensionality Reduction and Network Adaptation in Biochemical Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Joel Stavans (Weizmann Institute of Science, Israel)
"Robust, Coherent and Synchronized Circadian Clock-Controlled Oscillations Along Multicellular Cyanobacterial Filaments"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Rinat Arbel-Goren (Weizmann Institute of Science, Israel)
"Noisy Circadian Clocks Gate Cell Division in Anabaena "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ben Larson (University of California, San Francisco, USA)
"A Unicellular Walker Embodies a Finite State Machine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Ertugrul Ozbudak (Cincinnati Children's Hospital Medical Center, USA)
"Segmentation Clock Gene Pairing Drives Robust Pattern Formation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Andrew Mugler (University of Pittsburgh, USA)
"Physics of Flow Sensing in Cancer Metastasis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Matteo Mori (University of California, San Diego, USA)
"Principles of Gene Regulation Quantitatively Connect DNA to RNA and Proteins in Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Dynamics of Evolution and Ecology
Discussion Leader: Andrea Liu (University of Pennsylvania, USA)
7:30 pm - 8:00 pm
Michael Lynch (Arizona State University, USA)
"Drift, Mutation and the Origin of Cellular Features"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Terry Hwa (University of California, San Diego, USA)
"Stress-Induced Cross-Feeding Provides a Dynamic Mechanism of Microbial Cooperation"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Joseph Larkin (Boston University, USA)
"A Computational Model of Fractal Interface Formation in Bacterial Biofilms"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Corey Weistuch (Memorial Sloan Kettering Cancer Center, USA)
"Reconstructing the Evolutionary Dynamics of Liposarcoma"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Metabolism and Ageing
Discussion Leader: Daniel Needleman (Harvard University, USA)
9:00 am - 9:20 am
Murat Acar (Yale University, USA)
"Gene Expression and Noise Dynamics During Single-Cell Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hao Li (University of California, San Francisco, USA)
"Single Cell Aging from a Dynamic System's Perspective"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Denis Titov (University of California, Berkeley, USA)
"Towards Quantitative Models of Metabolism Regulation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Danica Chen (University of California, Berkeley, USA)
"Mitochondrial Metabolic Checkpoint, Stem Cell Aging and Rejuvenation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Matt Kaeberlein (University of Washington, USA)
"Harnessing A.I. and Robotics to Accelerate Longevity Drug Discovery"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Xingbo Yang (Harvard University, USA)
"A Coarse-Grained NADH Redox Model Enables Inference of Subcellular Metabolic Fluxes from Fluorescence Lifetime Imaging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sruthi Sivakumar (University of Pittsburgh, USA)
"Is Aging Accompanied By 'Biological Wisdom'?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phase Separation and Macromolecular Assembly in Biology
Discussion Leader: Wallace Marshall (University of California, San Francisco, USA)
7:30 pm - 7:50 pm
Stephanie Weber (McGill University, Canada)
"Bacteria Stabilize Transcriptional Condensates During Acid Stress"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Dennis Discher (University of Pennsylvania, USA)
"Multi-Cellular Phase Separation: Clustered Cooperating Macrophages Engulf Solid Tumors and Initiate Anti-Cancer Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Olga Dudko (University of California, San Diego, USA)
"Chromosomal Organization in Space and Time"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Susan Liao (Courant Institute of Mathematical Sciences, New York University, USA)
"At the Interface of Phase Separation: Simple Mechanisms for Complex RNA Processing"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Margaret Johnson (Johns Hopkins University, USA)
"Optimizing Against Kinetic Trapping in Hetero- and Homo-Subunit Protein Assemblies"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure