Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Stochastic Physics in Health
Discussion Leader: Purushottam Dixit (Yale University, United States)
7:40 pm - 8:15 pm
Alexander M. Cruickshank Lecture: Leor Weinberger (University of California, San Francisco / Gladstone Institutes , United States)
"The Cell’s Bunsen Burner: Discovery of a Cellular Pathway that Regulates Noise to Control Cell Fate"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Natalia Komarova (University of California Irvine, United States)
"Stochastic Modeling of Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jin Wang (State University of New York at Stony Brook, United States)
"Nonequilibrium Dynamics Across the Scales"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Sensing and Signaling
Discussion Leader: Wallace Marshall (University of California, San Francisco, United States)
9:00 am - 9:20 am
Pieter Ten Wolde (AMOLF, The Netherlands)
"Optimal Cellular Prediction"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Dongyang Li (Caltech, United States)
"Developing Synthetic Phosphorylation-Based Protein Circuits"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Yuhai Tu (IBM Thomas J. Watson Research Center, United States)
"Allostery in Large Protein Complexes: Equilibrium Versus Nonequilibrium Sensing Mechanisms"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Marianne Bauer (TU Delft, The Netherlands)
"Sensing Transcription Factors in the Fly Embryo"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ben Machta (Yale University, United States)
"Comparing Sensory Fidelity to Physical Bounds"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Thierry Emonet (Yale University, United States)
"Measuring Information Processing in Individual Bacteria"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Brian Camley (Johns Hopkins University, United States)
"Physical Limits to Sensing Electric Fields by Receptor Electrophoresis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Deepa Rajan (University of California, San Francisco (UCSF), United States)
"Single-Cell Analysis of Habituation in Stentor Coeruleus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Hong Qian (University of Washington, United States) and Sarah Veatch (University of Michigan, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modeling of Cellular Processes
Discussion Leader: Christine Payne (Duke University, United States)
7:30 pm - 7:50 pm
Jian Liu (Johns Hopkins University, United States)
"Spatial Control Over Near-Critical-Point Operation Ensures Fidelity of ParABS-mediated DNA Partition"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jay Newby (University of Alberta, Canada)
"Object Recognition and Tracking in Micron Scale Living Systems"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Kwadwo Bonsu (University of California, Irvine, United States)
"Mathematical Modeling and Bioinformatic Analysis to Investigate Multigenerational Epigenetic Stability of DNA Methylation Landscapes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Rikki Garner (Harvard Medical School, United States)
"Leading Edge Maintenance in Migrating Cells is an Emergent Property of Branched Actin Network Growth"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Moumita Das (Rochester Institute of Technology, United States)
"Mechanics of Structurally Correlated Disordered Networks in Cells and Tissues"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Thermodynamics of Biological Systems
Discussion Leader: Herbert Levine (Northeastern University, United States)
9:00 am - 9:20 am
Ken Dill (Stony Brook University, SUNY, United States)
"Darwinian Evolution as a Matter of Physical Dynamical Principle"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Shankar Mukherji (Washington University, United States)
"Uncovering the Principles Coordinating Systems-Level Organelle Biogenesis with Cellular Growth"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Thierry Mora (Ecole normale superieure & CNRS, France)
"Prediction, Adaptation, and Entropy Production"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Erin Angelini (University of Washington, United States)
"Stochastic Physics of the Single Cell by the Method of Willard Gibbs"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Albert Lau (Johns Hopkins University School of Medicine, United States)
"Glutamate Receptor Ligand-Binding Processes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Prakash Kulkarni (City of Hope Medical Center, United States)
"Intrinsically Disordered Proteins and Plasticity: From Conformational Ensembles to Phenotypic Switching"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Hong Qian (University of Washington, United States)
"Gibbs' Free Energy Theory Generalized and Mathematical Foundation of Statistical Physics"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Douglas Shepherd (Arizona State University, United States)
"Decoding the Hydrodynamic Properties of Microscale Helical Propellers from Brownian Fluctuations"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biological Models and Pathways
Discussion Leader: Andrew Mugler (University of Pittsburgh, United States)
7:30 pm - 7:50 pm
Hilary Coller (University of California, Los Angeles, United States)
"Dynamic Modeling Reveals Multiple Points of Regulation in the Autophagy Pathway as Fibroblasts Enter Quiescence"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Brian Munsky (Colorado State University, United States)
"Quantifying and Mitigating the Effects that Image Distortion Have on the Inference of Stochastic Models for Single-Cell Gene Regulation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Arvind Murugan (University of Chicago, United States)
"Evolution of Non-Equilibrium Proofreading"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Elizabeth Jerison (University of Chicago, United States)
"Activation of a Collective Gene Expression Mode in Tissue During a Runaway Inflammatory Response"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jun Allard (University of California, United States)
"Biophysics of T Cell Activation on Fluid Dynamic, Gene Regulatory, and Ultra-Slow Timescales"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbial Behaviors in Single Cells and in Communities
Discussion Leader: Keng-hui Lin (Academia Sinica, Taiwan)
9:00 am - 9:20 am
Wenying Shou (University College London, United Kingdom)
"How You Can Tell Whether Correlations Between Time Series Are Meaningful"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Linda Kenney (University of Texas Medical Branch, United States)
"Master Regulator SsrB Drives a Lifestyle Switch Between Virulence and Biofilms in Salmonella"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Naama Brenner (Technion - Israel Institute of Technology, Israel)
"Leader Cell Triggers Growth Resumption: Insight From Extreme Value Theory"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Purushottam Dixit (Yale University, United States)
"SMbiot: A Shared Latent Model for Microbiomes and Their Hosts"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Dervis Vural (University of Notre Dame, United States)
"Predicting and Controlling Evolving Ecological Communities"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Jing Yan (Yale University, United States)
"Morphogenesis, Cell Ordering, and Gene Expression in Confined Bacterial Biofilms"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Satya Spandana Boddu (Emory University, United States)
"Variation in C. Elegans Gut Microbiome is a Result of Host Heterogeneity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pattern Formation in Biological Systems
Discussion Leader: Margaret Johnson (Johns Hopkins University, United States)
7:30 pm - 7:50 pm
Orit Peleg (University of Colorado Boulder, United States)
"Emergent Spatiotemporal Patterns in Insect Swarms"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Keng-hui Lin (Academia Sinica, Taiwan)
"Mechanical Waves Identify Amputation Position During Wound Healing in Zebrafish Tailfin"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Bin Zhang (Massachusetts Institute of Technology, United States)
"Genome Organization Through Phase Separation: Random Yet Precise"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Longzhi Tan (Stanford University, United States)
"Probing the Single-Cell 3D Genome Architectural Basis of Neurodevelopment and Aging in Vivo"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Marlis Denk-Lobnig (University of Michigan, United States)
"Spatial Patterns Emerge from Social Interactions of Bacterial Populations Under Antibiotic Exposure"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Growth and Development
Discussion Leader: Elizabeth Read (University of California, Irvine, United States)
9:00 am - 9:20 am
Susan Rosenberg (Baylor College of Medicine, United States)
"The DNA Damageome and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jin Yu (University of California, Irvine, United States)
"Probing Transcription Machinery in Modules Via Physical Modeling and Computational Interrogation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Lev Tsimring (University of California, San Diego, United States)
"Statistical Theory of Asymmetric Damage Segregation in Clonal Cell Populations"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Nicolas Yehya (Johns Hopkins School of Medicine, United States)
"Single Molecule Measurements of DNA Topology Effects on Transcription Kinetics"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Vernita Gordon (The University of Texas at Austin, United States)
"Bacterial Survival and Response to Stress"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Motasem ElGamel (University of Pittsburgh, United States)
"Effects of Molecular Noise on Cell Size Control"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Avaneesh Narla (University of California, San Diego, United States)
"Dynamic Coexistence Due to Growth Succession in Cyclic Microbial Ecosystems"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Salil Garg (Yale University, United States)
"Transcription Factor Antagonism Regulates Heterogeneity in Embryonic Stem Cell States"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Robert Brewster (UMASS Chan Medical School, United States)
"Untangling the Regulatory Role of Individual TFs in E. Coli"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Spatial Organization of Biological Functions and Activities
Discussion Leader: Susan Rosenberg (Baylor College of Medicine, United States)
7:30 pm - 7:50 pm
Christine Payne (Duke University, United States)
"Measuring and Controlling the Resting Membrane Potential of Bacteria: Spatial and Temporal Heterogeneity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Jonathan Fischer (Johns Hopkins University, United States)
"Dynamically Tuning the Membrane Lipid Composition Can Control Macromolecular Assembly"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Yaojun Zhang (Johns Hopkins University, United States)
"Alien Proteomics Reveals Physical Rules for Diffusion Through the Nuclear Pore"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sarah Veatch (University of Michigan, United States)
"Responsive Assembly of Signaling Domains at the Plasma Membrane"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Keren Lasker (The Scripps Research Institute, United States)
"The Material Properties of a Bacterial-Derived PopZ Condensate Tune Biological Function in Natural and Synthetic Systems"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rabia Laghmach (Iowa State University, United States)
"Mesoscale Modeling of the Dynamics of Phase-Separated Chromatin Compartments in Eukaryotic Nucelus"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure