Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Protein Quality Control and Aging
Discussion Leaders: Kevin Morano (University of Texas Medical School at Houston, USA) and Elke Deuerling (University of Konstanz, Germany)
7:40 pm - 8:20 pm
Judith Frydman (Stanford University, USA)
"Proteostasis Function and Dysfunction: The Delicate Art of Maintaining a Healthy Proteome"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Jonathan Weissman (University of California, San Francisco / Howard Hughes Medical Institute, USA)
"Monitoring Translation in Space and Time with Ribosome Profiling"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Folding and Misfolding
Discussion Leader: James Bardwell (University of Michigan / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 am
Bernd Bukau (University of Heidelberg, Germany)
"Chaperone Action in Folding and Disaggregation of Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elizabeth Craig (University of Wisconsin-Madison, USA)
"How Do J-Proteins Get Hsp70 to Do So Many Different Things?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ulrich Hartl (Max-Planck Institute of Biochemistry, Germany)
"Chaperone Functions in Protein Folding and Proteostasis Maintenance"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Manajit Heyer-Hartl (Max Planck Institute of Biochemistry, Germany)
"A New Twist in the Mechanism of the GroEL/GroES Chaperonin System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Stephanie Gates (University of Michigan, USA)
"Translocation Mechanism of the Hsp104 Disaggregase Determined by Cryo-EM"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Shelli McAlpine (University of New South Wales, Australia)
"Small Molecules that Control Cell Survival Pathways Through Inhibiting Hsp70"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Carolyn Sevier (Cornell University, USA)
"Molecular Mechanisms to Maintain Cellular Redox Homeostasis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Elke Deuerling (University of Konstanz, Germany)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sensing and Signaling: the Ribosome and Beyond
Discussion Leader: Harm Kampinga (University Medical Center Groningen, The Netherlands)
7:30 pm - 7:50 pm
Onn Brandman (Stanford University, USA)
"Ribosome Associated Protein Quality Control"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Claudio Joazeiro (University of Heidelberg, Germany)
"Ribosome-Associated Protein Quality Control (RQC)"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Olga Sin (Max Planck Institute for Molecular Biomedicine, Germany)
"Aggregation-Prone Proteins that Require Ssb1 and Ssb2 Molecular Chaperones Are Not Translated Slower than Non-Aggregation-Prone Proteins"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Anat Ben-Zvi (Ben-Gurion University of the Negev, Israel)
"The Dynamic Landscape of Molecular Chaperones Across Tissues"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Johannes Buchner (Technische Universitaet Muenchen, Germany)
"The Structure and Function of an Essential Co-Chaperone of Hsp90"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Quality Control and Disease
Discussion Leader: Jonathan Weissman (University of California, San Francisco / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 am
Andrew Lieberman (University of Michigan Medical School, USA)
"Proteasome Dysfunction in Polyglutamine Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jan Hoeijmakers (Erasmus University Medical Center, The Netherlands)
"The Contribution of Aging to Neurodegeneration: From DNA Damage to Protein Aggregates"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Magdalini Polymenidou (University of Zurich, Switzerland)
"The Intertwined Roles of RNA Misregulation and Protein Aggregation in ALS and FTD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
"Surviving Protein Quality Control Failure in Cells and Organisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Peter Douglas (University of Texas Southwestern Medical Center, USA)
"Uncovering the Cellular Response to Mechanical Stress: What Can a Worm Teach Us About Traumatic Brain Injury?"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Nadinath Nillegoda (Center for Molecular Biology (ZMBH), Heidelberg University and German Cancer Research Center (DKFZ), Germany)
"Evolution of an Intricate J-Protein Network Driving Protein Disaggregation in Eukaryotic Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Anniina Vihervaara (Cornell University, USA)
"Transcriptional Response to Stress Is Pre-Wired by Promoter and Enhancer Architecture"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aggregates, Assemblies and Depots
Discussion Leader: Judith Frydman (Stanford University, USA)
7:30 pm - 7:50 pm
Simon Alberti (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Organizing Living Matter in Stressed Cells: Phase Transitions as a Survival Strategy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
David Allan Drummond (University of Chicago, USA)
"How Cells Use Quinary Regulation to Sense and Respond to Stress"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Paul Herman (Ohio State University, USA)
"P-Bodies, RNP Granules and Protein Quality Control"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Frederick Stull (University of Michigan / Howard Hughes Medical Institute, USA)
"Acid-Induced Chloride Accumulation Leads to Cytotoxic Protein Aggregation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Daniel Jarosz (Stanford University, USA)
"Quality Control and Aggregation in the Aging Vertebrate Proteome"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Homeostasis in the Endoplasmic Reticulum
Discussion Leader: Andrew Dillin (University of California, Berkeley / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 am
Linda Hendershot (St. Jude Children's Research Hospital, USA)
"Protein Folding and Quality Control via the Hsp70 System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kazuhiro Nagata (Kyoto Sangyo University, Japan)
"Regulation of ER Homeostasis by Redox Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maho Niwa (University of California, San Diego, USA)
"ER Stress Response During the Cell Cycle"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Ron (University of Cambridge, United Kingdom)
"Early Events in the Endoplasmic Reticulum Unfolded Protein Response"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Teresa Buck (University of Pittsburgh, USA)
"Regulation of ENaC (Epithelial Sodium Channel) by the ER Lumenal Chaperone, GRP170"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ashley Frakes (University of California, Berkeley, USA)
"Glial Regulation of ER Stress Resistance and Longevity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jan Reiling (BioMed X Innovation Center, Germany)
"TRAPPC13 Modulates Autophagy and the Response to Golgi Stress"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteinopathies: Aging and Defense Strategies
Discussion Leader: Jeffrey Brodsky (University of Pittsburgh, USA)
7:30 pm - 7:50 pm
Ursula Jakob (University of Michigan, USA)
"Role of Polyphosphate in Amyloidogenic Processes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Richard Morimoto (Northwestern University, USA)
"Resetting Organismal Proteostasis Through Epigenetic and Mitochondrial Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Martin Duennwald (University of Western Ontario, Canada)
"Hsp90 and Its Co-Chaperones Regulate ALS-Related Proteinopathies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Alex Jaeger (Whitehead Institute for Biomedical Research, MIT, USA)
"Limiting the Buffer Function of HSP90 Markedly Enhances Tumor Immunogenicity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Carmen Nussbaum-Krammer (University of Heidelberg, Germany)
"C. elegans Model for Prion-Like Spreading of a-Syn Reveals New Genetic Modifiers of Cell to Cell Transmission"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Protein Triage and Degradation
Discussion Leader: Lea Sistonen (Abo Akademi University, Finland)
9:00 am - 9:20 am
Andreas Matouschek (The University of Texas at Austin, USA)
"How the Proteasome Selects Proteins for Degradation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Thomas Nystrom (University of Gothenburg, Sweden)
"Regulation of Protease vs. Co-Chaperone Activity of a Metacaspase - Turning an Executioner into a Protector"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kylie Walters (National Cancer Institute, NIH, USA)
"Substrate Recognition by the Proteasome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Veena Prahlad (University of Iowa, USA)
"Sensory Experience and Learning Modulate the Expression of Molecular Chaperones in C. elegans "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Rachel Cliffe (University of Cambridge, United Kingdom)
"Filamentous Aggregates Are Disassembled by the Proteasome in a Ubiquitin-Independent Manner"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Liming Li (Northwestern University, USA)
"Heritable Switches in Conformation and Transcriptional Regulation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Hugo Tapia (University of California, Berkeley, USA)
"Hsp12 and Trehalose: Necessary and Sufficient Desiccation Stress Effectors"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Control of Stress Protein Expression
Discussion Leader: Jason Gestwicki (University of California, San Francisco, USA)
5:30 pm - 5:50 pm
Brian Freeman (University of Illinois at Urbana-Champaign, USA)
"Molecular Chaperones Regulate the Chromatin Landscape - Is It Time to Move?"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
David Gross (LSU Health Sciences Center New Orleans, USA)
"Hsf1 Restructures the Yeast Genome in Response to Heat Shock"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Dennis Thiele (Duke University School of Medicine, USA)
"The Atypical Regulation of Heat Shock Factors in Disease"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Selected from Poster Abstracts: Sara Peffer (The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA)
"Defining the Regulatory Interaction of Ssa1/Hsp70 with Hsf1"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Selected from Poster Abstracts: David Pincus (Whitehead Institute for Biomedical Research, MIT, USA)
"Essential Function and Dynamic Regulation of Yeast Heat Shock Factor"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure