Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: From Basic Mechanisms of Proteostasis to Bedside Applications
We will have two keynote speakers to open the meeting: Prof. Elizabeth A. Craig is a world leading expert on understanding the functions and mechanisms of chaperones in proteostasis, while Prof. Jeffery W. Kelly is a world leading expert trying to understand the underlying principles of protein misfolding diseases and developing new small-molecule therapeutic strategies to combat such diseases.
Discussion Leader: Brian Freeman (University of Illinois at Urbana-Champaign, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Elizabeth Craig (University of Wisconsin-Madison, USA)
"Evolution of Complex Hsp70 Molecular Chaperone Machinery"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Jeffery Kelly (Scripps Research, USA)
"Small Molecule Restoration of Protein Homeostasis in Degenerative Diseases"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptionally and Translationally Controlled Management of Protein Homeostasis
This session will cover new insights into the reprogramming of transcription and translation upon stress.
Discussion Leader: Judith Frydman (Stanford University, USA)
9:00 am - 9:20 am
Ritwick Sawarkar (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Transcriptional Control of Proteostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Susan Ackerman (University of California, San Diego / Howard Hughes Medical Institute, USA)
"Defects in mRNA Translation and Neurodegeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Daniel Jarosz (Stanford University, USA)
"Hidden in Plain Sight: An Adaptive Gene Expression Program Activated by a Pervasive Non-Amyloid Prion"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: John Hanna (Harvard Medical School, USA)
"Thiol-Based Direct Sensing of a Proteotoxic Threat by the Stress-Activated Protein Kinase Hog1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ellen Nollen (European Research Institute of the Biology of Ageing (ERIBA), The Netherlands)
"Biological Modifiers of Protein Aggregation and Toxicity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Lea Sistonen (Åbo Akademi University, Finland)
"Transcriptional Memory Accelerates Promoter-Proximal Pause-Release and Decelerates Termination over Mitotic Divisions"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Martin Gamerdinger (University of Konstanz, Germany)
"Ab Initio Guidance of Nascent Polypeptides Inside the Ribosomal Tunnel by NAC"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Ursula Jakob (University of Michigan, USA) and Brian Freeman (University of Illinois at Urbana-Champaign, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanisms of Protein Folding, Misfolding and Aggregation
This session is about understanding the role and mechanisms by which chaperones and other stress-inducible factors promote protein folding in cells and manage misfolded and damaged proteins.
Discussion Leader: Manajit Hayer-Hartl (Max Planck Institute of Biochemistry, Germany)
6:00 pm - 6:20 pm
Bernd Bukau (Heidelberg University / German Cancer Research Center, Germany)
"Chaperone Action in Protein Disaggregation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Matthias Mayer (University of Heidelberg, Germany)
"Allostery and Dynamics of Hsp70 Proteins"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Stefan Rudiger (Utrecht University, The Netherlands)
"Chaperoning Aggregation of the Alzheimer Protein Tau"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Kevin Morano (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Thiol Stress and Proteostasis in Yeast"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Phase Separation and Other Deposits of Proteins and RNA
This session will highlight newest developments on how phase separation and the deposition of proteins or RNA under stress impacts on proteostasis.
Discussion Leader: Rachel Klevit (University of Washington, USA)
9:00 am - 9:20 am
F. Ulrich Hartl (Max Planck Institute of Biochemistry, Germany)
"The Nucleolus Is a Phase-Separated Protein Quality Control Compartment with Novel Chaperone-Like Properties"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Monica Driscoll (Rutgers University, USA)
"Stress-Induced Trash Expulsion as a Novel Proteo- and Mito-Stress Resistance Pathway?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Carmen Nussbaum-Krammer (Heidelberg University, Germany)
"Reducing Insulin/IGF1 Signaling Protects Against Non-Cell Autonomous Vesicle Rupture Caused by Alpha-Synuclein Spreading"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Vladislav Belyy (University of California, San Francisco, USA)
"Human IRE1 Is Reversibly Trapped in the Cores of Stress-Induced Clusters"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Allan Drummond (The University of Chicago, USA)
"Chaperone-Mediated Dispersal of Endogenous Stress-Triggered Assemblies"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Matthias Truttmann (University of Michigan Medical School, USA)
"Chaperone AMPylation Modulates Aggregation and Toxicity of Neurodegenerative Disease-Associated Polypeptides"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Janine Kirstein (Leibniz Institute for Molecular Pharmacology, Germany)
"A Novel Model to Visualize and Quantify Amyloid-Beta Fibrilization In Vivo "
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Quality Control Mechanisms
This session will discuss advances in protein quality pathways at multiple levels and how these systems impact on human protein misfolding disease.
Discussion Leader: Luke Wiseman (The Scripps Research Institute, USA)
6:00 pm - 6:20 pm
Judith Frydman (Stanford University, USA)
"Chaperone Mechanisms and Pathways in Eukaryotic Proteostasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Kai Fenzl (Zentrum fuer Molekulare Biologie, Heidelberg University, Germany)
"Cotranslational Assembly of Homo-Oligomers Involves Interaction of Two Nascent Complex Subunits"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Selected from Poster Abstracts: Ranen Aviner (Stanford University, USA)
"Remodeling of Co-Translational Proteostasis Networks by RNA Viruses Offers Insight into New Antiviral Strategies"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Claudio Joazeiro (Heidelberg University, Germany)
"Ribosome-Associated Quality Control"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Selected from Poster Abstracts: Kelsey Hickey (University of California, San Francisco, USA)
"Translation Inhibition Coupled with the RQC to Maintain Proteostasis upon Ribosome Stalling"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Selected from Poster Abstracts: Phillip Frankino (University of California, Berkeley, USA)
"Astrocyte-Like Glial Cells of C. elegans Non-Cell Autonomously Regulate Induction of the Cytosolic Unfolded Protein Response"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stress Responses of Organelles
This session will discuss the importance of the protein homeostasis machinery in the ER and in mitochondria and how alterations in protein quality control in organelles contribute to aging and disease.
Discussion Leader: Anat Ben-Zvi (Ben-Gurion University of the Negev, Israel)
9:00 am - 9:20 am
Linda Hendershot (St. Jude Children's Research Hospital, USA)
"Specificity in the ER Hsp70 Family Substrate Recognition Sequences Underlies Aggregation Inhibition and Protein Quality Control"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jeffrey Brodsky (University of Pittsburgh, USA)
"The Various Fates of Misfolded Membrane Proteins in the Endoplasmic Reticulum"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Luke Wiseman (The Scripps Research Institute, USA)
"The Source of the Problem: Endoplasmic Reticulum Proteostasis and Systemic Amyloid Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Andrew Dillin (University of California, Berkeley / Howard Hughes Medical Institute, USA)
"Systemic Control of ER Proteostasis in Aging and Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Piotr Bragoszewski (University of Warsaw, Poland)
"Cytosolic Quality Control of Mitochondrial Protein Biogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Martin Kampmann (University of California, San Francisco, USA)
"A CRISPRi Screen Uncovers a Novel Factor Mediating the Mitochondrial Unfolded Protein Response in Mammalian Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Christian Münch (Goethe University Frankfurt, Germany)
"Mitophagy Induction by the Mitochondrial Unfolded Protein Response"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Protein Triage and Degradation
This session will cover the intersection between chaperone recognition of damaged proteins and the decision to refold a protein or to hand it over to a degradation system e.g. the proteasome.
Discussion Leader: Andrew Dillin (University of California, Berkeley / Howard Hughes Medical Institute, USA)
6:00 pm - 6:20 pm
Ivan Dikic (Goethe University Frankfurt, Germany)
"Unconventional Serine Ubiquitination and Cellular Stress Responses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Stephanie Gates (University of California, Berkeley, USA)
"Cryo-EM Structures of the Substrate-Engaged 26S Proteasome Reveal the Mechanisms for ATP-Hydrolysis Driven Translocation"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Thomas Langer (Max Planck Institute for Biology of Ageing, Germany)
"Proteolytic Rewiring of Mitochondria in Hypoxia"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Selected from Poster Abstracts: Parijat Majumder (Max Planck Institute of Biochemistry, Germany)
"Cryo-EM Structures of the Archaeoglobus fulgidus PAN-Proteasome Elucidate an Around-the-Ring ATPase Cycle"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Peter Chien (University of Massachusetts Amherst, USA)
"Regulated Proteolysis During Bacterial Stress Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Autophagy During Health, Aging and Disease
This session will highlight the importance of protein clearance by autophagy and how this impacts on the stress management during health, aging and disease.
Discussion Leader: Ursula Jakob (University of Michigan, USA)
9:00 am - 9:20 am
David Rubinsztein (University of Cambridge, United Kingdom)
"Autophagy and Neurodegeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Noor Gammoh (The University of Edinburgh, United Kingdom)
"Regulation of Early Endosome Homeostasis by Autophagy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Su Hyun Lee (Seoul National University, South Korea)
"Regulation of Autophagic Proteolysis by the N-Recognin SQSTM1/p62"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Steven Bergink (University Medical Center Groningen, The Netherlands)
"Genomic Stress Results in an Imbalance in Protein Homeostasis, Leading to Degenerative Phenotypes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Reut Shalgi (Technion - Israel Institute of Technology, Israel)
"Cellular Proteostasis Collapse in Mammalian Senescence"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Janhavi Kolhe (University of Illinois at Urbana-Champaign, USA)
"Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Harm Kampinga (University Medical Center Groningen, The Netherlands)
"Chaperonopathies: How Mutations in Chaperones Can Lead to Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Invention Strategies to Combat Disease and Aging
This session will cover proteostasis dysfunctions and will offer intervention strategies to combat protein misfolding diseases.
Discussion Leader: Jeffery Kelly (Scripps Research, USA)
6:00 pm - 6:20 pm
Ursula Jakob (University of Michigan, USA)
"Early Life Reactive Oxygen Species Target Histone Methylation to Individualize Stress Resistance and Lifespan"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Selected from Poster Abstracts: Gregory Blatch (The University of Notre Dame Australia, Australia)
"Dealing with Stress at the Host-Parasite Interface: Functional Interaction of a Plasmodial Exported Hsp40 with Hsp70"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Paul Workman (CRUK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom)
"Targeting Non-Oncogene Addiction with HSF1 Pathway Inhibitors: Chemical Biology and Drug Discovery"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Selected from Poster Abstracts: John Labbadia (University College London, United Kingdom)
"Protein Phosphatase 2A Couples Mitochondrial Stress with Increased HSF1 Activity to Protect Against Age-Related Proteostasis Collapse"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Richard Morimoto (Northwestern University, USA)
"Enhancing Organismal Proteostasis in Aging, Stress and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure