Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: From the Decline of Proteostasis with Aging to the Protein Machines Supporting Proteostasis
Discussion Leader: Harm Kampinga (University Medical Center Groningen, The Netherlands)
7:40 pm - 8:25 pm
Johannes Buchner (Technical University of Munich, Germany)
"Regulation of Chaperone Machineries"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Elke Deuerling (University of Konstanz, Germany)
"Sensing and Sorting of Nascent Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Aggregation and Phase Transitions During Health, Aging, and Disease
Discussion Leader: Jeffery Kelly (The Scripps Research Institute, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Simon Alberti (Technical University of Dresden, Germany)
"Biomolecular Condensates at the Nexus of Cellular Stress, Disease and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Mario Mauthe (University Medical Center Groningen (UMCG), The Netherlands)
"Chaperone-Mediated Fragmentation of Aggregates is Essential for Autophagic Turnover"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Manajit Hayer-Hartl (Max Planck Institute of Biochemistry, Germany)
"Role of Phase Separation in Biogenesis of a Bacterial Microcompartment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
James Shorter (University of Pennsylvania, United States)
"Countering Deleterious Phase Transitions in Neurodegenerative Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Martin Duennwald (University of Western Ontario, Canada)
"DnaJC7 Function Under Proteostatic Stress and in ALS"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Anita Manogaran (Marquette University, United States)
"Link Between Newly Formed Protein Aggregates and the Actin Cytoskeleton"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Mark Hipp (University Medical Center Groningen (UMCG), The Netherlands)
"The AAA+ Chaperone VCP Modifies Multiple Steps in the Spreading of Tau Aggregates"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Patricija van Oosten-Hawle (UNC Charlotte, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Signaling Systems Governing the Protein Homeostasis Network
Discussion Leader: Monica Driscoll (Rutgers University, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Heinrich Jasper (Genentech, Inc., United States)
"Stress Signaling in Aging Stem Cells"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Carmen Nussbaum-Krammer (Ludwig-Maximilians-University of Munich, Germany)
"A New C. Elegans Model for Intercellular Tau Spreading Discovers a Central Role for (Sphingo-)Lipid Metabolism in Maintaining Endo-Lysosomal Integrity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Chengkai Dai (National Cancer Institute, NIH, United States)
"A Powerful Enabler of Oncogenesis: Implications of HSF1 in Proteomic Instability and Non-Oncogene Addiction of Cancer"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Marcia Haigis (Harvard Medical School, United States)
"Cancer and Aging: Metabolites and Stress in the Tumor Niche"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Gene Regulatory Responses to Stress and Aging
Discussion Leader: Richard Morimoto (Northwestern University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
John Lis (Cornell University, United States)
"Transcriptional Activation and Repression Mechanisms Collaborate to Regulate the Genome in Response to Heat Stress"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
David Gross (Louisiana State University Health Sciences Center, United States)
"Transcriptional Condensates Restructure the Yeast Genome in Response to Stress"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Audrey Peng (University of Illinois Urbana-Champaign, United States)
"Investigating the Nuclear Role of TRiC"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Veena Prahlad (Roswell Park Comprehensive Cancer Center, United States)
"Neuronal Control of C. elegans p53 Activity by Cytokine Release Modulates Developmental Quiescence"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kevin Morano (McGovern Medical School, UTHealth Houston, United States)
"Redox Interactions with the Heat Shock Response and Spatial Quality Control"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Peter Douglas (University of Texas Southwestern Medical Center, United States)
"Adaptation through the Dopaminergic Stress Response Pathway"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Lea Sistonen (Åbo Akademi University, Finland)
"Novel Targets of HSFs in Cellular Stress Responses and Cell-Cell Adhesion"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Translation Events Influencing Protein Homeostasis
Discussion Leader: Judith Frydman (Stanford University, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
W. Lee Kraus (University of Texas Southwestern Medical Center, United States)
"Role of Ribosome Mono(ADP-ribosyl)ation in Cellular Stress Responses in Cancer"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Ramon Duran (VIB, Belgium)
"N-Glycosylation Expands the Repertoire of Protein Aggregation Gatekeepers"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Maria Vera (McGill University, Canada)
"Imaging Single mRNAs Uncovers Neuronal Mechanisms to Sustain Protein Homeostasis"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Anne Bertolotti (MRC LMB Cambridge, United Kingdom)
"The Ups and Downs of eIF2a Phosphorylation"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Daniel Jarosz (Stanford University, United States)
"Widespread Conformational Memory in the Human Proteome"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Chaperone Machines
Discussion Leader: F. Ulrich Hartl (Max Planck Institute of Biochemistry, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Justin Benesch (University of Oxford, United Kingdom)
"Small Heat-Shock Proteins in the Muscle Machinery"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Martin Haslbeck (Technische Universität München, Germany)
"Topological Separation of the N-terminal Regions in the Permanently Active Small Heat Shock Protein Hsp17"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Vladimir Denic (Harvard University, United States)
"A New System of Bespoke Chaperones Essential for eEF1A Biogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Didier Picard (University of Geneva, Switzerland)
"How Much Hsp90 is Enough for Mammalian Development and in Chronic Stress and Why"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Lukasz Joachimiak (UT Southwestern Medical Center, United States)
"DNAJB8 Oligomerization is Mediated by an Aromatic-Rich Motif that is Dispensable for Substrate Activity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Wei Xu (University of Wisconsin-Madison, United States)
"Diptoindonesin G is a Middle Domain HSP90 Modulator for Cancer Treatment"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Lila Gierasch (University of Massachusetts Amherst, United States)
"Hsp70 Chaperone Machines and their Promiscuous yet Specific Substrate Binding"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Stress Responses of the Endoplasmic Reticulum with Age
Discussion Leader: Jeffrey Brodsky (University of Pittsburgh, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Liza Pon (Columbia University, United States)
"Role for Lipid Droplets and Microautophagy in ER Protein Quality Control"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Rosalie Lawrence (UCSF, United States)
"A Central Helical Fulcrum in eIF2B Coordinates Allosteric Regulation of Stress Signaling"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Helmut Kramer (UT Southwestern, United States)
"The Allnighter Pseudokinase Regulates Stress Responses During Neuronal Adaptation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Gloria Brar (University of California, Berkeley, United States)
"Cellular Resetting of the Sod1 Pool by Programmed Aggregation and Degradation During Gametogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Quality Control
Discussion Leader: Harm Kampinga (University Medical Center Groningen, The Netherlands)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Wade Harper (Harvard Medical School, United States)
"Mechanisms of Organelle Quality Control by Autophagy"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Ekaterina Lobanova (University of Florida, United States)
"Targeting Proteasomes to Delay Vision Loss"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Kapil Ramachandran (Columbia University Medical Center, United States)
"Dysregulation of Neuroproteasomes by ApoE Isoforms Drives Endogenous Tau Aggregation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Diane Haakonsen (University of California at Berkeley, United States)
"Accurate Timing of Stress Response Inactivation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rachel Klevit (University of Washington, United States)
"Not all Disorder is Created Equal: Functional Disorder in Small Heat Shock Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Malene Hansen (Buck Institute for Aging Research, United States)
"Regulation of Autophagy in Aging and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Frank Echtenkamp (NIH-NCI, United States)
"Mitoribosome Sensitivity to Hsp70 Inhibition Uncovers Metabolic Liabilities of CRPC and Re-sensitizes to Androgen Deprivation Therapies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mitochondrial Function During Aging and Stress
Discussion Leader: Andrew Dillin (University of California, Berkeley, United States)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
Xinnan Wang (Stanford University School of Medicine, United States)
"Stress-Primed Mitochondrial Adaptations"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Dhyan Chandra (Roswell Park Comprehensive Cancer Center, United States)
"Mitochondrial Unfolded Protein Response in Cancer Growth and Progression"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jonathan Weissman (Whitehead institute/MIT/HHMI, United States)
"Parallel Pathways and Topological Triaging Enables Robust Biogenesis of Mitochondrial Outer Membrane Proteins"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Patricija van Oosten-Hawle (UNC Charlotte, United States)
"Safeguarding Organismal Proteostasis by Transcellular Chaperone Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure