Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave
Discussion Leader: Martin Gamerdinger (University of Konstanz, Germany)
3:45 pm - 4:20 pm
Harm Kampinga (University Medical Center Groningen, The Netherlands)
"Heat Shock Proteins: Chaperoning Proteins from the Cradle to the Grave"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms Regulating Protein Folding and Aggregation
Discussion Leader: Olga Sin (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:40 pm
Thomas Alderson (National Institutes of Health, USA)
"Redox Regulation of HSP27 Through Conditional Disorder"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Amy Ford (UTHealth Graduate School of Biomedical Sciences at Houston, USA)
"Deciphering Impacts of Thiol Stress on Cytosolic Proteostasis in Yeast"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Madhu-Sudhan Ravindran (University of Michigan, USA)
"A Non-Enveloped Virus Exploits Host Quality Control Machineries to Translocate Across the Endoplasmic Reticulum Membrane"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Sabine Schmidt (University of Konstanz, Germany)
"Fluorescence-Based Analysis of Ribosome Assembly In Vivo "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Jay Goodman (University of California, Berkeley, USA)
"Protein Homeostasis and Vacuolar Remodeling in Budding Yeast Gametogenesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Dan Gestaut (Stanford University, USA)
"Structural and Mechanistic Characterization of the TRiC Prefoldin Folding Pathway"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Joseph Schonhoft (The Scripps Research Institute, USA)
"Peptide Probes Detect Misfolded Transthyretin Oligomers in the Plasma of Early Stage Hereditary Amyloidosis Patients"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Stress Protein Networks in Aging and Disease
Discussion Leader: Giorgio Gaglia (Whitehead Institute for Biomedical Research, MIT, USA)
9:00 am - 9:10 am
Stefanos Aivazidis (University of Colorado Denver, USA)
"The Burden of Trisomy 21 Disrupts the Proteostasis Network in Down Syndrome"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Lindsey Baker (Cold Spring Harbor Laboratory, USA)
"Changes in Protein Homeostasis and Response to Proteotoxic Stress Are Associated with Pancreatic Tumorigenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Greg Sienski (Whitehead Institute for Biomedical Research, MIT, USA)
"Molecular Mechanism of Action of a Major Alzheimer's Disease Risk Factor"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Ke Xia (Rensselaer Polytechnic Institute, USA)
"Increased Levels of Hyper-Stable Chaperone and Protein Aggregates in Plasma of Older Adults"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Chao Wang (The Scripps Research Institute, USA)
"Using High-Throughput Screening (HTS) to Promote Alpha-1 Antitrypsin Deficiency (AATD) Correction Through Proteostasis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Doris Hellerschmied (Yale University, USA)
"Unfolding of a Golgi-Localized Protein Identifies Important Protein Quality Control Mechanisms in the Early Secretory Pathway"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Adam De Graff (Stony Brook University, USA)
"Maintaining Proteostasis Till the Last Breath"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Nirmala Parajuli (University of Arkansas for Medical Sciences, USA)
"Role of Ubiquitin Proteasome System During Cold Storage Plus Transplantation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Effective Scientific Networking and Communication
An open forum to discuss effective ways to network and develop collaborations at the GRC.
Discussion Leader: Alex Jaeger (Whitehead Institute for Biomedical Research, MIT, USA)
1:30 pm - 2:30 pm
Panel Discussion
Effective Scientific Networking and Communication
James Bardwell (University of Michigan / Howard Hughes Medical Institute, USA)
Elke Deuerling (University of Konstanz, Germany)
Ursula Jakob (University of Michigan, USA)
Harm Kampinga (University Medical Center Groningen, The Netherlands)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
