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Stress Proteins in Growth, Development and Disease (GRS)

Gordon Research Seminar

Molecular Mechanisms and Physiological Consequences of (Un)Balanced Protein Homeostasis

June 22 - 23, 2019
Chairs Olga Sin and Julia Dendle Grandjean
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Stress Proteins in Growth, Development and Disease is meant for early career scientists—PhD students and post-docs—where they can share their work and views about cutting edge scientific research in the field of protein homeostasis (proteostasis). This year's GRS will cover the cellular and molecular mechanisms underlying protein homeostasis to how these are altered in complex human diseases.

The major goal of the GRS is to provide a friendly and collaborative atmosphere, where early career scientists with similar level of experience can network and exchange constructive feedback on others' work.

Related Meeting

This GRS will be held in conjunction with the "Stress Proteins in Growth, Development and Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Small Heat Shock Proteins
Rachel Klevit will serve as the inaugural keynote speaker for this GRS, and is a world expert in structural biology of small heat shock chaperones and protein ubiquitination.
Discussion Leader: Catherine Triandafillou (University of Chicago, USA)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:50 pm
Rachel Klevit (University of Washington, USA)
"(Order + Disorder + Fuzzy) = Small Heat Shock Proteins"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mechanisms Regulating Protein Folding and Aggregation
Discussion Leader: Robert Newberry (University of California, San Francisco, USA)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:45 pm
Wouter Huiting (University Medical Center Groningen, The Netherlands)
"Genomic Stress Is a Central Catalyst of Protein Aggregation"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:00 pm
Maura Garofalo (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
"Identification of Structural Determinants of Light Chain Amyloidosis"
6:00 pm - 6:05 pm
Discussion
6:05 pm - 6:15 pm
Yanxin Liu (University of California, San Francisco, USA)
"Cryo-EM Reveals the Interplay Between Mitochondrial Hsp90 and Client Protein"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:30 pm
Stephanie Moon (Howard Hughes Medical Institute / University of Colorado Boulder, USA)
"A Stress-Activated Ribosome-Associated Quality Control Complex Promotes mRNA Targeting to Stress Granules Through Ribosome Release"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:45 pm
Kotaro Tsuboyama (The University of Tokyo, Japan)
"A Widespread Family of Hydrophilic Hero Proteins Protect Against Protein Instability and Aggregation"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Unekwu Yakubu (McGovern Medical School, The University of Texas Health Science Center at Houston, USA)
"Systematic Mutations in Drosophila melanogaster Hsp110 Reveal a Novel Chaperoning Mechanism"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Ilia Korobko (Weizmann Institute of Science, Israel)
"Transient Kinetic Analysis of ATP Hydrolysis by the CCT/TRiC Chaperonin"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Stress Proteins Networks in Aging and Disease
Discussion Leader: Haneul Yoo (The University of Chicago, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Karina Gense (University of Konstanz, Germany)
"Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
Janhavi Kolhe (University of Illinois at Urbana-Champaign, USA)
"Expanding the Hsp90 Interactome"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Richard Giadone (Boston University School of Medicine, USA)
"Hepatic Proteostasis in the Pathogenesis of ATTR Amyloidosis"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Nima Naseri (Weill Cornell Medicine, USA)
"Aggregation of Mutant Cysteine String Protein-A via Ectopic Fe-S Cluster-Binding Is Mitigated by Iron Chelators"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Su Ran Mun (Seoul National University, South Korea)
"N-Terminal Arginylation Generates a Bimodal Degron for Proteasomal or Autophagic Proteolysis via the N-Degron Pathway"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Jorge Castillo-Quan (Joslin Diabetes Center, Harvard Medical School, USA)
"Lipid-Mediated Non-Degradative ERAD Processing of SKN-1A/Nrf1 Couples Redox, Lipid Catabolism and Proteostasis to Longevity"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
Sonia Brockway (Northwestern University, USA)
"Systematic Chemical-Genetic Profiling Reveals the Architecture of the Proteostasis Network in Breast Cancer"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Shaping Your Scientific Career
Discussion Leader: Jessica Kho (University of New South Wales, Australia)
1:30 pm - 2:30 pm
Panel Discussion
Making the Right Moves: Shaping Your Scientific Career
  • Jeffrey Brodsky (University of Pittsburgh, USA)
  • Elizabeth Craig (University of Wisconsin-Madison, USA)
  • Daniel Jarosz (Stanford University, USA)
  • Ellen Nollen (European Research Institute of the Biology of Ageing (ERIBA), The Netherlands)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health - National Institute on Aging
Calico Life Sciences
New England BioLabs, Inc.
Proteostasis Therapeutics, Inc.

Research reported in this publication was supported by the National Institute on Aging of the National Institute of Health under Award Number R13AG06484. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health.

Conference Links

Conference History Stress Proteins in Growth, Development and Disease
Additional Fee Info

Stress Proteins in Growth, Development and Disease
July 6 - 11, 2025


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