Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Telling Right From Wrong: Principles of Misfolded Protein Recognition and Spatial Quality Control
Discussion Leader: Koning Shen (UC Berkeley, United States)
3:15 pm - 3:45 pm
Judith Frydman (Stanford University, United States)
"Telling Right From Wrong: Principles of Misfolded Protein Recognition and Spatial Quality Control"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mechanisms Regulating Protein Folding and Aggregation
Discussion Leader: Adam Knier (Marquette University, United States)
5:30 pm - 5:50 pm
Introduction by Discussion Leader
5:50 pm - 6:05 pm
Liina Sirvio (IMPERIAL COLLEGE London, United Kingdom)
"Aggregates are Targeted for Degradation by Phase-Separated Proteasome Droplets"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Emma Lacroix (Simon Fraser University, Canada)
"Evolutionary Conservation of Systemic and Reversible Amyloid Aggregation"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Sofia Bali (UT Southwestern Medical Center, United States)
"Local Intramolecular Interactions Mediate the Intrinsic Regulation of Tau Amyloid Assembly."
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Austin Klein (Northwestern University, United States)
"Delineating the Cellular Proteostasis Network using a Comprehensive Chemical-Genetic Approach"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Richard Giadone (Harvard University, United States)
"Heterochronic Parabiosis Alters the Proteostasis Environment of the Aging Mouse Brain"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Stress Protein Networks in Development, Disease, and Aging
Discussion Leader: Jessica Rosarda (The Scripps Research Institute, United States)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:35 am
Giovanni Mastromarco (University of Toronto, Canada)
"Role of Protein Homeostasis Machinery in Stress Granule Disassembly and Limiting ALS-Associated Protein Aggregation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Wiktoria Sadowska (Kavli Institute for Nanoscience Discovery, University of Oxford, United Kingdom)
"Reuniting Evolutionarily Separated Small Heat-Shock Protein Using Native Mass Spectrometry"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Isabella Damiani (Stanford University, United States)
"Electronic Cigarette Exposure Induces Unfolded Protein Response and Protein Aggregation in Vascular Smooth Muscle Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jon Hibshman (University of North Carolina, United States)
"Identification of New and Potent Desiccation Protectants from Tardigrades"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Margot Van Nerom (Vrije Universiteit Brussel, Belgium)
"C9orf72-Linked Arginine-Rich Dipeptide Repeats Aggravate Pathological Phase Separation of G3BP1"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Shaping your Scientific Career: A Mentorship Q&A with Faculty
Discussion Leader: Hannah Buchholz (Marquette University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Shaping your Scientific Career
Andrew Dillin (University of California, Berkeley, United States)
Manajit Hayer-Hartl (Max Planck Institute of Biochemistry, Germany)
Vladimir Denic (Harvard University, United States)
Patricija van Oosten-Hawle (UNC Charlotte, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
