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Synaptic Transmission

Gordon Research Conference

Integrating the Regulation of Synaptic Transmission Across Cellular and Circuit Levels

August 12 - 17, 2018

Chair Kristen M. Harris

Vice Chair Alison Barth

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

We have emphasized integration across pre-, post-, and peri- synaptic signaling. Talks regarding post-synaptic receptors and downstream responses are juxtaposed with the regulation of presynaptic release throughout the meeting. The bidirectional influence of synaptic transmission and nuclear function and transcription is featured as is synapse structure and function at high resolution. Synapse development and plasticity are key components of synaptic transmission and are integrated across sessions. Understanding disease processes that affect or are mediated by synapses will also be added to several appropriate sessions, rather than being a separate session. This full integration is an innovative approach to encourage the engagement of all perspectives throughout the entire meeting. We have achieved a healthy balance of senior and junior scientists. Senior scientists have established reputations that draw attendees to a meeting and are able to initiate lively discussions. Junior scientists provide fresh ideas and often have a better understanding of modern innovations and technical details. To maximize the contribution of young investigators, we have expanded the "Short Talk" selections. Based on the submitted abstracts, ten students/postdocs/junior faculty members will be chosen for brief talks. We expect to identify "rising neuroscience stars" for these talks.

Funding Assistance

We have obtained NIH and private funding for this conference to support some of your costs to attend the meeting. As many other GRCs have done, we would like to allocate as much funding as possible for junior faculty, postdocs, students, and others who may have limited resources.

If you require funding assistance to attend this GRC, please send a brief paragraph (less than 150 words) explaining your request for financial support to amescherich@austin.utexas.edu.

We will do our best to allocate funding to support as many of these requests as possible.

Regards,
Kristen and Alison

Related Meeting

This GRC will be held in conjunction with the "Synaptic Transmission" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Late-Breaking Topics: Rapid Transmission of Synaptic Ideas This session is designed to bring all the participants together in a rapid set of poster introductions – 1 slide per person on Sunday evening. This rapid format is highly engaging and geared to alert all conferees to posters that will be presented by non-speakers at the meeting. The vice chair will receive 1 slide of the key point of a poster at least 4 days prior to the meeting so as to compose a continuous presentation allowing about 2 minutes per speaker. Discussion Leader: Alison Barth (Carnegie Mellon University, USA)
7:40 pm - 9:30 pm	Poster Previews
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Dynamic Regulation of Synaptic Transmission by Protein Turnover and Signaling to the Nucleus Discussion Leader: Graeme Davis (University of California, San Francisco, USA)
9:00 am - 9:20 am	Ege Kavalali (University of Texas Southwestern Medical Center, USA) "Single Synaptic Vesicle Exo-Endocytosis Coupling"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Silvio Rizzoli (University of Goettingen School of Medicine, Germany) "The Molecular Organization of Synaptic Protein Turnover"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Group Photo / Coffee Break
10:30 am - 10:50 am	Anne West (Duke University Medical Center, USA) "Synaptic Activity-Dependent Regulation of Transcription"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	Daniel Choquet (CNRS, France) "Dynamic Nanoscale Organization of AMPA Receptors and Synaptic Plasticity"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: Angela Wild (University of Colorado Denver, USA) "Synapse-to-Nucleus Communication Through NFAT Is Mediated by Rapid L-Type Ca²⁺ Channel-Dependent Electrochemical Signaling to the Soma"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Brenda Bloodgood (University of California, San Diego, USA) "Communication Between Synapses and the Genome"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	Power Hour The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. Organizer: Alison Barth (Carnegie Mellon University, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Resource Management and Synaptic Plasticity Discussion Leader: Christine Gall (University of California, Irvine, USA)
7:30 pm - 7:50 pm	Thomas Schwarz (Boston Children's Hospital, USA) "How Mitochondria Get to the Synapse and Support Function"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: Carolina Borges-Merjane (Institute of Science and Technology Austria, Austria) "Structural Correlates of Transmitter Release and Readily Releasable Vesicle Pool at Hippocampal Mossy Fiber Synapses"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Terry Sejnowski (Salk Institute for Biological Studies, USA) "Life at Low Molecule Number"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Xiaochen Sun (Massachusetts Institute of Technology, USA) "Bi-Directional Regulation of the Balance Between Memory Discrimination and Generalization by Functionally Distinct Neuronal Ensembles Within the Memory Engram"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Cristina Alberini (New York University, USA) "Synaptic Molecular Mechanisms of Critical Period in Memory Formation During Early Development"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Bidirectional Regulation of Presynaptic Release and Postsynaptic Response Discussion Leader: Mary Kennedy (California Institute of Technology, USA)
9:00 am - 9:20 am	Graeme Davis (University of California, San Francisco, USA) "Retrograde Homeostatic Trans-Synaptic Signaling"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Lori McMahon (University of Alabama at Birmingham, USA) "O-GlucNAcylation Depresses Excitatory and Inhibitory Transmission in Area CA1 and Dampens Hyperexcitabity via Targeting GluA2 AMPARs"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	Shernaz Bamji (University of British Columbia, Canada) "Post-Translational Palmitoylation and Its Regulation of Synapse Plasticity"
10:50 am - 11:00 am	Discussion
11:00 am - 11:10 am	Selected from Poster Abstracts: John Gray (University of California, Davis, USA) "Cell-Autonomous Regulation of Synaptic NMDA Receptors by Postsynaptic Serine Racemase"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	Susumu Tomita (Yale University, USA) "Molecular Machinery to Control Synaptic Transmission"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Angus Silver (University College London, United Kingdom) "Presynaptic Population Activity in the Cerebellar Cortex During Locomotion"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Synaptogenesis and Synaptic Plasticity Discussion Leader: Thomas Schwarz (Boston Children's Hospital, USA)
7:30 pm - 7:50 pm	Takao Hensch (Harvard University, USA) "Perineuronal Nets and Parvalbumin Network Plasticity"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: Kelly Carstens (National lnstitute of Environmental Health Sciences, NIH, USA) "Perineuronal Nets in a Mouse Model of Rett Syndrome: Regulation by Activity and Disease in the Hippocampus"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	A. Kimberley McAllister (University of California, Davis, USA) "Interleukin-1β Alters Cortical Connectivity Through Dynamic Changes in IL-1β Receptor Localization and MHCI Signaling"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Julie Nys (VIB-KU Leuven Center for Brain & Disease Research, Belgium) "Activity-Dependent Regulation of Neuroligin-3 Levels at Excitatory and Inhibitory Synapses by the Sorting Receptor SorCS1"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Christine Gall (University of California, Irvine, USA) "The Many Faces of LTP: Pathway Specific Variants of Memory-Related Plasticity"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Presynaptic Release, Postsynaptic Response, Calcium and Structural Plasticity Discussion Leader: Scott Soderling (Duke University, USA)
9:00 am - 9:20 am	Samuel Young (University of Iowa, USA) "Molecular Mechanisms Regulating Presynaptic Calcium Channel Subtype Levels and Organization to Drive Neuronal Circuit Function"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Andres Barria (University of Washington, USA) "Regulation of Glutamatergic Synapses by Wnt Signaling"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Mary Kennedy (California Institute of Technology, USA) "The Role of Liquid-Liquid Phase Transitions in Shaping the Postsynaptic Density Scaffold: Why We Should Care"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Kim Raab-Graham (Wake Forest School of Medicine, USA) "Posttranscriptional Regulation of Calcium Dynamics in Autism Spectrum Disorders"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: Antonio Martinez-Sanchez (Max Planck Institute of Biochemistry, Germany) "Template-Free Detection and Classification of Heterogeneous Membrane-Bound Complexes in Cryo-Electron Tomograms: Ionotropic Glutamated Receptors Analyzed In Situ"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Matthew Kennedy (University of Colorado School of Medicine, USA) "Defining the Organelles and Mechanisms of Unconventional Secretory Trafficking in Neuronal Dendrites"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Synaptic Circuit Structure and Function Discussion Leader: Mala Shah (University College London, United Kingdom)
7:30 pm - 7:50 pm	Scott Soderling (Duke University, USA) "Charting the Molecular Landscape of Diverse Synapses In Vivo"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: Katharine Smith (University of Colorado Denver, USA) "Super-Resolution Imaging of Inhibitory Synapses During Synaptic Plasticity"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Dan Johnston (University of Texas at Austin, USA) "Dendritic Channelopathies in Fragile X Syndrome"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Selected from Poster Abstracts: Jonathan Murphy (National Institutes of Health, USA) "Conservation of Ca²⁺ Regulation Among A-Type Potassium Channel Complexes"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Jaideep Bains (University of Calgary, Canada) "Social Transmission and Buffering of Synaptic Plasticity"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Specificity in Regulating Synaptic Transmission Discussion Leader: Shernaz Bamji (University of British Columbia, Canada)
9:00 am - 9:20 am	Mala Shah (University College London, United Kingdom) "Synapse Specific Regulation of Neurotransmitter Release by Voltage-Gated K+ Channels"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Nicola Allen (Salk Institute for Biological Studies, USA) "Astrocyte Regulation of Neuronal Glutamate Receptors"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Tallie Z. Baram (University of California, Irvine, USA) "Synaptic and Memory Effects of Acute Traumatic Stresses: Molecules and Mechanisms"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Graham Knott (Ecole Polytechnique Federale de Lausanne, Switzerland) "The Ultrastructure of Neuromodulatory Axons"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: Qian-Quan Sun (University of Wyoming, USA) "Circuit-Specific and Neuronal Subcellular-Wide Excitatory and Inhibitory Synaptic Balance in Cortical Pyramidal Cells"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	K. Ulrich (Ulli) Bayer (University of Colorado School of Medicine, USA) "CaMKII: Form and Function of a Central Synaptic Regulator"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Keynote Session: Biochemical Computation in Single Dendritic Spines Discussion Leader: Kristen Harris (University of Texas at Austin, USA)
5:30 pm - 5:45 pm	Introduction by Discussion Leader
5:45 pm - 6:45 pm	Ryohei Yasuda (Max Planck Florida Institute for Neuroscience, USA) "Biochemical Computation in Single Dendritic Spines"
6:45 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	General Discussion
7:20 pm - 7:30 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute of Neurological Disorders and Stroke of the National Institute of Health under Award Number 1R13NS106860. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Health.

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