Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Presynaptic Function in Health and Disease
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:55 pm
"Dynamic Control and Plasticity of Presynaptic Function In Health and Disease"
8:55 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Metabolic Vulnerabilities and Metabolic Solutions in Synapse Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Adaptable Synaptic Fidelity and Inter-Synaptic Crosstalk In The Intact Brain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Defining the Synapse Using SYNGO"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Regulation of Protein Translation in Neural Transmission"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Rapid Homeostatic Modulation of Synaptic Connectivity In The Adult Mouse Hippocampus"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Presynaptic Rac1 Controls Synaptic Strength Though Regulation of Synaptic Vesicle Priming"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Resolving Postsynaptic AMPA Receptor Dynamics and Presynaptic Glutamate Release During Short-Term Plasticity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Direct Visualization of Triheteromeric NMDA Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Imaging Synaptic Structure
6:00 pm - 6:20 pm
"Using Advanced Electron Microscopy to Reveal the Impact of Resource Distribution on Synapse Clustering"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Multiscale Imaging of Inhibitory Synaptic Function During Visual Behavior"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"High-Speed Volumetric Imaging of Neural Activity with Synaptic Resolution"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Outside Matters: Super-Resolution Imaging of Brain Extracellular Spaces and Dynamics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
In Vivo Synaptic Transmission
9:00 am - 9:20 am
"Processing of Top-Down Information in Neocortical Layer 1"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Cellular Coding of Temperature In The Mammalian Cortex"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Interneuron Signalling in the Mouse Dentate Gyrus In Vivo"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Neural Basis of Anticipation and Premature Impulsive Action in the Frontal Cortex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Layer-specific Modification of Neocortical SST Output During Learning"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Sharp-wave Ripple Doublets Induce Complex Dendritic Spikes In Hippocampal Parvalbumin Interneurons In Vivo"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Calcium-Permeable AMPA Receptors Govern PV Neuron Orientation Selectivity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Seeing Dopamine by the Light of AndromeDA: Imaging Neuronal Dopamine Secretion Using a Nanosensor 'Paint'"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Synaptic Computation and Network Design
6:00 pm - 6:20 pm
"Modelling Synaptic Plasticity and Computation in Neural Circuits"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Burstprop: A Mechanistic Theory for the Orchestration of Learning in Cortex"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Fabric of the Neocortex: A Less Artificial Intelligence"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Interaction Between Network Dynamics and Short-Term Synaptic Plasticity Inverts the Algorithm of a Disinhibitory Microcircuit"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synapses Function in Disease
9:00 am - 9:20 am
"Neuronal Calcium Channel Trafficking and Function: Relevance to Chronic Pain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Development of the Human Brain: From the Embryo to 3D Organoids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Non-Canonical Role of Glutamatergic NMDA Receptors in Health and Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
"ASD-Associated Chromatin Remodellers In Synaptic Transmission"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mutations on Stxbp1 Gene Affect Aynaptic Transmission In Human iPSC-Derived Glutamatergic Neurons"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"NMDA Receptor Synaptic Transmission is Modulated by The Amyloid Precursor Protein (APP) in an Age-dependent Manner"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Excitatory Dysfunction Drives Network and Calcium Handling Deficits in a 16p11.2 Duplication iPSC-Derived Neuronal Model of Schizophrenia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Synaptic Architecture as a Function of Alpha-synuclein in Health and Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neural Excitability and Synaptic Regulation
6:00 pm - 6:20 pm
"Sodium Channel Function on Both Sides of the Synapse"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Firing Rate Homeostasis in Hippocampal Circuits: From Basic Principles to Malfunctions"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Molecular Determinants of the Functional Properties of Hippocampal Glutamatergic Synapses"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Non-Canonical Intracellular Signaling Pathway Underlying Cholinergic M1 Receptor-Induced Axonal Action Potential Threshold Plasticity in Hippocampal Neurons"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Brief Synaptic Inhibition Persistently Interrupts Firing of Fast-Spiking Interneurons"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Mechanisms of Experience-Dependent Hippocampal Representations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Synaptic Phagocytosis by Oligodendrocyte Progenitors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"A Synaptic Weight Gradient Mechanism for Control of Directional Behaviors"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Dopaminergic Modulation of Aversive Learning in the Anterior Cingulate Cortex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Visualizing The Molecular Ultrastructure of Synapses With Cryo-Electron Tomography"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanisms Underlying the Stepwise Disassembly of Inhibitory Synapses during Pathogenic Excitotoxicity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Synaptic Mechanism For Encoding Time Within Neural Circuits"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Synapses and Social Behavior
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:10 pm
"From Synapses to Sociability: A Scientific Journey"
7:10 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure