Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Presynaptic Function in Health and Disease
Discussion Leaders: Ana Luisa Carvalho (University of Coimbra, Portugal)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:55 pm
Nils Brose (Max Planck Institute for Multidisciplinary Sciences - Goettingen - Germany, Germany)
"Dynamic Control and Plasticity of Presynaptic Function In Health and Disease"
8:55 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Presynaptic Regulation
Discussion Leader: Noa Lipstein (FMP-Berlin, Germany)
9:00 am - 9:20 am
Timothy Ryan (Weill Cornell Medicine, United States)
"Metabolic Vulnerabilities and Metabolic Solutions in Synapse Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dmitri Rusakov (UCL Queen Square Institute of Neurology, University College London, United Kingdom)
"Adaptable Synaptic Fidelity and Inter-Synaptic Crosstalk In The Intact Brain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Matthijs Verhage (Center for Neurogenomics and Cognitive Research (CNCR), The Netherlands)
"Defining the Synapse Using SYNGO"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Yishi Jin (University of California San Diego, United States)
"Regulation of Protein Translation in Neural Transmission"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Peter Chipman (UCSF, United States)
"Rapid Homeostatic Modulation of Synaptic Connectivity In The Adult Mouse Hippocampus"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Samuel Young (University of Iowa, United States)
"Presynaptic Rac1 Controls Synaptic Strength Though Regulation of Synaptic Vesicle Priming"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Angela Getz (Interdisciplinary Institute for Neuroscience (IINS), University of Bordeaux, France)
"Resolving Postsynaptic AMPA Receptor Dynamics and Presynaptic Glutamate Release During Short-Term Plasticity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Michael Anderson (1:00-3:00, United States)
"Direct Visualization of Triheteromeric NMDA Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Alison Barth (Carnegie Mellon University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Imaging Synaptic Structure
Discussion Leader: Thomas Blanpied (University of Maryland School of Medicine, United States)
6:00 pm - 6:20 pm
Kristen Harris (University of Texas at Austin, United States)
"Using Advanced Electron Microscopy to Reveal the Impact of Resource Distribution on Synapse Clustering"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Michael Higley (Yale University, United States)
"Multiscale Imaging of Inhibitory Synaptic Function During Visual Behavior"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Na Ji (University of California, Berkeley, United States)
"High-Speed Volumetric Imaging of Neural Activity with Synaptic Resolution"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Julie Kauer (Stanford University, United States)
"Outside Matters: Super-Resolution Imaging of Brain Extracellular Spaces and Dynamics"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
In Vivo Synaptic Transmission
Discussion Leader: Graeme Davis (University of California, San Francisco, United States)
9:00 am - 9:20 am
Johannes Letzkus (University of Freiburg, Germany)
"Processing of Top-Down Information in Neocortical Layer 1"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
James Poulet (Max Delbrück Center, Germany)
"The Cellular Coding of Temperature In The Mammalian Cortex"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Marlene Bartos (University of Freiburg, Germany)
"Interneuron Signalling in the Mouse Dentate Gyrus In Vivo"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Lu-Yang Wang (SickKids Research Institute / University of Toronto, Canada)
"Neural Basis of Anticipation and Premature Impulsive Action in the Frontal Cortex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Eunsol Park (Carnegie Mellon University, United States)
"Layer-specific Modification of Neocortical SST Output During Learning"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Balazs J. Rózsa (BrainVisionCenter, Hungary)
"Sharp-wave Ripple Doublets Induce Complex Dendritic Spikes In Hippocampal Parvalbumin Interneurons In Vivo"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ingie Hong (Johns Hopkins Medical Institute, United States)
"Calcium-Permeable AMPA Receptors Govern PV Neuron Orientation Selectivity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
James Daniel (Max Planck Institute for Multidisciplinary Sciences, Germany)
"Seeing Dopamine by the Light of AndromeDA: Imaging Neuronal Dopamine Secretion Using a Nanosensor 'Paint'"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Synaptic Computation and Network Design
Discussion Leader: Srikanth Ramaswamy (Newcastle University, United Kingdom)
6:00 pm - 6:20 pm
Ian Cone (Imperial College London, United Kingdom)
"Modelling Synaptic Plasticity and Computation in Neural Circuits"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Richard Naud (University of Ottawa, Canada)
"Burstprop: A Mechanistic Theory for the Orchestration of Learning in Cortex"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Andreas Tolias (Baylor College of Medicine, United States)
"The Fabric of the Neocortex: A Less Artificial Intelligence"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Wei Wei (University of Chicago, United States)
"Interaction Between Network Dynamics and Short-Term Synaptic Plasticity Inverts the Algorithm of a Disinhibitory Microcircuit"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synapses Function in Disease
Discussion Leader: Bruce Herring (University of Southern California, United States)
9:00 am - 9:20 am
Annette Dolphin (University College London (UCL), United Kingdom)
"Neuronal Calcium Channel Trafficking and Function: Relevance to Chronic Pain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Noa Lipstein (FMP-Berlin, Germany)
"Development of the Human Brain: From the Embryo to 3D Organoids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Laurent Groc (CNRS / University of Bordeaux, France)
"Non-Canonical Role of Glutamatergic NMDA Receptors in Health and Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Gaia Novarino (Institute of Science and Technology Austria (ISTA), Austria)
"ASD-Associated Chromatin Remodellers In Synaptic Transmission"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Paola Barbagallo (University of Copenhagen, Denmark)
"Mutations on Stxbp1 Gene Affect Aynaptic Transmission In Human iPSC-Derived Glutamatergic Neurons"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Paula Pousinha (CNRS UMR 7275 - IPMC, France)
"NMDA Receptor Synaptic Transmission is Modulated by The Amyloid Precursor Protein (APP) in an Age-dependent Manner"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Euan Parnell (Northwestern University, United States)
"Excitatory Dysfunction Drives Network and Calcium Handling Deficits in a 16p11.2 Duplication iPSC-Derived Neuronal Model of Schizophrenia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Luis Fonseca-Ornelas (Harvard Medical School and Brigham and Women's Hospital, United States)
"Synaptic Architecture as a Function of Alpha-synuclein in Health and Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Neural Excitability and Synaptic Regulation
Discussion Leader: Pablo Castillo (Albert Einstein College of Medicine, United States)
6:00 pm - 6:20 pm
Kevin Bender (University of California, San Francisco, United States)
"Sodium Channel Function on Both Sides of the Synapse"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Inna Slutsky (Tel Aviv University, Israel)
"Firing Rate Homeostasis in Hippocampal Circuits: From Basic Principles to Malfunctions"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Zoltan Nusser (Institute of Experimental Medicine, Hungary)
"Molecular Determinants of the Functional Properties of Hippocampal Glutamatergic Synapses"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Mala Shah (University College London, United Kingdom)
"Non-Canonical Intracellular Signaling Pathway Underlying Cholinergic M1 Receptor-Induced Axonal Action Potential Threshold Plasticity in Hippocampal Neurons"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Simon Chamberland (New York University, United States)
"Brief Synaptic Inhibition Persistently Interrupts Firing of Fast-Spiking Interneurons"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Dynamic Synaptic Control
Discussion Leader: Ralf Schneggenburger (Ecole Polytechnique Federale de Lausanne, Switzerland)
9:00 am - 9:20 am
Jeff Magee (Howard Hughes Medical Insitute, United States)
"Mechanisms of Experience-Dependent Hippocampal Representations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lucas Cheadle (Cold Spring Harbor Laboratory, United States)
"Synaptic Phagocytosis by Oligodendrocyte Progenitors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Gwyneth Card (Janelia Research Campus, Howard Hughes Medical Institute, United States)
"A Synaptic Weight Gradient Mechanism for Control of Directional Behaviors"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Thomas Nevian (University of Bern, Switzerland)
"Dopaminergic Modulation of Aversive Learning in the Anterior Cingulate Cortex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Nele Marie Burdina (University of Cologne, Germany)
"Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Richard Held (Stanford University/HHMI, United States)
"Visualizing The Molecular Ultrastructure of Synapses With Cryo-Electron Tomography"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Joshua Garcia (University of Colorado Anschutz Medical Campus, United States)
"Mechanisms Underlying the Stepwise Disassembly of Inhibitory Synapses during Pathogenic Excitotoxicity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
David Digregorio (Institut Pasteur, France)
"A Synaptic Mechanism For Encoding Time Within Neural Circuits"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Synapses and Social Behavior
Discussion Leaders: Helene Marie (Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), France)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:10 pm
Robert Malenka (Stanford University School of Medicine, United States)
"From Synapses to Sociability: A Scientific Journey"
7:10 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure