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Synaptic Transmission

Gordon Research Conference

Synapse Organization and Function Across Scales

July 14 - 19, 2024

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

ATTENTION: The GRC bus picks up and drops off at the Florence Airport (FLR) only. GRC no longer has bus service to / from the Pisa Airport.

The Synaptic Transmission GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 Synaptic Transmission Gordon Research Conference will bring together international leaders and rising stars in the fields of synapse development and structure/function, learning-related activity dependent and homeostatic synaptic plasticity, and the synaptic origins of disease. This conference will create a diverse and dynamic forum to communicate, contemplate and advance our understanding of the most pressing and fascinating current topics in synapse biology. Among these topics: How is synapse diversity established and sustained? How does synapse nanoscale organization relate to synapse type-specific function? How do we reconcile learning-related and homeostatic plasticity mechanisms? What is the synaptic pathophysiology associated with neurological and psychiatric disease, and how might these pathophysiologies be corrected?

Related Meeting

This GRC will be held in conjunction with the "Synaptic Transmission" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Activity, Transcription, Translation and Synapse Modification Discussion Leader:
7:40 pm - 8:00 pm	"How Do Astrocytes Sculpt Synaptic Circuits in Health and Disease?"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"How Information is Persistently Stored in a Hippocampus-Dependent Long-Term Memory"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	"Protein Supply and Demand at Synapses"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell Biology of Synapse Function and Plasticity Discussion Leader:
9:00 am - 9:20 am	"Spatial and Temporal Control of Synaptic Transmission"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"MicroRNA-Mediated Control of Synaptic Transmission and Neuronal Network Activity in Chronic Stress"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"An Extracellular Complex between Punctin/MADD-4 and Collagen XVIII/CLE-1 Controls Synapse Identity in C. Elegans"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"New Tools for Visualizing and Manipulating Endogenous AMPA-Type Glutamate Receptors"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Mapping the Nanoscale Topography of Synaptic Proteins using Cryo-Electron Tomography"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Investigation of Native AMPA Receptor Complexes within Brain Tissue by Cryo-Electron Tomography"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"In-Vivo Plasticity of Synaptic Nano-Architecture as Revealed by STED Microscopy"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"MLAModification of Synaptic Nanoscale Organization Alter the LTD-Pruning Sequence in Neurodevelopmental Diseases"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Synapse Evolution and Function Across Systems Discussion Leader:
6:00 pm - 6:20 pm	"Post-Tetanic Stabilization of Synaptic Transmission"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"LAMolecular Basis of Fast Neurotransmitter-Independent Synaptic Signaling in the Mammalian CNS"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:45 pm	"The Deep Evolutionary Origins of Synapses and Neurons"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Synapse and Networks Discussion Leader:
9:00 am - 9:20 am	"Synaptic Heterogeneity Across Individual Neurons"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"The Nanoscale Organization of Inhibitory Synapses in Plasticity and Disease"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"A Longitudinal Analysis of the Connectivity of Parallel Fibers to Purkinje Cells in Postnatal Life via Serial Section Electron Microscopy"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Early Cellular Memories Reveal the Sequence and Mechanisms of Circuit Maturation During Early Development"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Role of Cytoskeletal ß-Spectrins in Dendritic Spines Development and Function"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Synaptic Strength in Prefrontal Cortex Regulates Homeostatic Sleep Need"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Postsynaptic Machinery for Local Control of mRNA Translation and Memory Storage"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"A Neuroglial Circuit for Maternal Behavior"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Synapses in Health and Disease Discussion Leader:
6:00 pm - 6:20 pm	"Shaping Connectivity Motifs and Network Computations through Plasticity"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Ketamine Alleviates NMDA Receptor Hypofunction through Synaptic Trapping"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Elucidating the Role of Presynaptic a2d1-3 Proteins in the Regulation of Synaptic Function"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:45 pm	"Regulation of AMPA Receptors during Synaptic Plasticity in Health and Disease"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Synaptic Basis of Network Function Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Fine-Scale Rewiring of the Cortical Circuit During Learning"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"LACortical Input to Substantia Nigra Pars Lateralis Dopaminergic Neurons Modulates Auditory Fear Learning"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Mapping Spatial Organization of Functional Inputs in Valence-Related Amygdalo-Hippocampal Circuits"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:05 am	"Negative Regulation of Excitatory Synaptic Efficacy by microRNA-138 in the Cerebellar Cortex"
11:05 am - 11:10 am	Discussion
11:10 am - 11:20 am	"Revised Roles of Cyclic Nucleotides in the Long-Term Synaptic Plasticity Underlying Olfactory Associative Learning in Drosophila"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Nanoscale Calcium Signals Driven by NMDAR and mGlu5R are Spatially Segregated in the Postsynaptic Compartment"
11:35 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"CaMKII and the Making of Memories"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Molecular Mechanisms of Synapse Plasticity Discussion Leader:
6:00 pm - 6:20 pm	"Glia-Neuron Interaction in Presynaptic Homeostatic Plasticity"
6:20 pm - 6:25 pm	Discussion
6:25 pm - 6:35 pm	"Regulation of NMDA Receptors Trafficking by Wnt Signaling"
6:35 pm - 6:40 pm	Discussion
6:40 pm - 6:50 pm	"Cellular Substrate of Synaptic Eligibility Traces in Cortex"
6:50 pm - 6:55 pm	Discussion
6:55 pm - 7:15 pm	"Early and Persistent Changes in Connectivity after Optogenetic STDP"
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:40 pm	"Role of the N-Terminal Domain in Ampa Receptor Localisation at the Synapse in Ltp and Stp"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"The Role of cAMP Degrading Phosphodiesterase PDE4A5 in Modulating AMPA Receptors at Postsynaptic Sites"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Synapses Architecture and Regulation Across Scales Discussion Leader:
9:00 am - 9:20 am	"Liquid-Liquid Phase Separation and Synaptic Plasticity"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Protein-Lipid Interactions Drive Presynaptic Assembly Upstream of Cell Adhesion Molecules"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Different States of Synaptic Vesicle Priming Explain Target Cell Type–Dependent Differences in Neurotransmitter Release"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Synaptic Receptor-Ribosome Coupling in Dendritic Spines"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Phase Separation of Postsynaptic Proteins at the Nanoscale Is Regulated by Development and Structural Plasticity"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Connecting Structure and Function: Characterization of Munc13-1/UNC-13"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"A Serotonergic Axon-Cilium Synapse"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Novel iGluR Signaling in the Brain"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Emerging Cellular and Molecular Mechanisms Discussion Leader:
6:00 pm - 6:20 pm	"Synaptome Architecture in the Mouse and Human Brain"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Synapse- and Activity-Specific Regulation of Ampar Mobility Controls Synaptic Integration by Tuning Frequency-Dependent Plasticity"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"BDNF Induces its Own Release to Mediate Presynaptic Plasticity"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Coupling Synaptic Excitation to Transcription via Dendrite-to-Soma Ca2+ Spike Propagation and Kinase/Phosphatase Signaling to the Nucleus"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by R13NS137523 from National Institute Of Neurological Disorders And Stroke of the National Institutes of Health The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Synaptic Transmission (GRS)

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