Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Genome Design, Synthesis, and Editing
Genome scale synthetic biology.
Discussion Leaders: Jumai Abioye (University of Glasgow, United Kingdom) and Barbara Jusiak (Massachusetts Institute of Technology, USA)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Neta Agmon (NYU Langone Medical Center, USA)
"Human to Yeast Pathway Transplantation: Cross-Species Dissection of the Adenine De Novo Pathway Regulatory Node"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Yorke Zhang (The Scripps Research Institute, USA)
"A Semi-Synthetic Organism with an Expanded Genetic Code"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Pathways
Biosynthetic pathways and synthetic signaling pathways logic for controlling cellular behavior.
Discussion Leaders: David Garcia (Oak Ridge National Laboratory, USA) and Ciaran Kelly (Imperial College London, United Kingdom)
7:30 pm - 7:45 pm
Ben Thuronyi (Harvard University, USA)
"Directed Evolution of Nucleobase Editors"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Kimberly Insigne (University of California, Los Angeles, USA)
"Using Synthetic Biology to Crack the Splicing Code"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Brynne Stanton (Ginkgo Bioworks, USA)
"Engineering Enzymes, Pathways, and Microbes Through the Use of an Automated Organism Engineering Foundry"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Ariel Langevin (Boston University, USA)
"Benefit of Stress Response Genes Is Dependent on Dynamics of Environment"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Benjamin Scott (University of Toronto, Canada)
"High-Throughput Studies of Human GPCRs Using Yeast"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Shiva Razavi (Johns Hopkins University School of Medicine, USA)
"Bottom-Up Engineering of Chemotaxis in Artificial Cells"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Synthetic Biological Devices
Design, synthesis, and/or evolution of proteins and nucleic acids exhibiting new functions.
Discussion Leaders: Cesar de la Fuente-Nunez (Massachusetts Institute of Technology, USA) and Tanya Tschirhart (Naval Research Laboratory, USA)
9:00 am - 9:15 am
Indra Bervoets (Vrije Universiteit Brussel, Belgium)
"A Sigma Factor Toolbox Enables Orthogonal Gene Expression for Modular Control of Complex Pathways in Escherichia coli "
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Scott Boyken (University of Washington, USA)
"De Novo Design of Protein Logic via Hydrogen Bond Network-Mediated Specificity: New Tools to Engineer Cellular Signaling"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
James Italia (Boston College, USA)
"Universal Platforms for Genetic Code Expansion in E. coli and Mammalian Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jongmin Kim (Wyss Institute, Harvard University, USA)
"Complex Cellular Logic Computation Using Ribocomputing Devices"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tim Kükenshöner (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Selective Targeting of Src Family Tyrosine Kinases with Monobodies"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Vanessa Restrepo Schild (University of Oxford, United Kingdom)
"Reconstructing Vision from the Bottom Up"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Innovation Challenge
Mentors
from industry and academia will lead breakout groups in brainstorming ideas for
the next biotech start-up or for new niches in academic research.
Discussion Leaders: Emily Leproust (Twist Bioscience, USA), Brynne Stanton (Ginkgo Bioworks, USA) and Michael Mee (Flagship Pioneering, USA)
1:30 pm - 2:30 pm
Breakout Group Discussions: Innovation Challenge
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes