Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Bottom-up Construction of Complex Chemical Systems
Discussion Leader: David Lynn (Emory University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Jo Handelsman (Wisconsin Institute for Discovery, USA)
"Understanding Diversity in Microbial Communities"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Sara Walker (Arizona State University, USA)
"New Physics from Systems Chemistry: Realizing the Goal to Understand the 'Laws of Life'"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alternative Genetic Systems
Discussion Leader: Martha Grover (Georgia Institute of Technology, USA)
9:00 am - 9:30 am
Philipp Holliger (MRC Laboratory of Molecular Biology, University of Cambridge, United Kingdom)
"RNA Polymerase Ribozymes and the Primordial RNA 'Genome'"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Dieter Braun (Ludwig Maximilian University of Munich, Germany)
"Molecular Evolution in Microscale Experiments"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jennifer Heemstra (Emory University, USA)
"Harnessing Nucleic Acid Molecular Recognition and Self-Assembly for Small-Molecule Biosensing"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
John Chaput (University of California, Irvine, USA)
"Synthetic Biology Using Xeno-Nucleic Acids"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Henderson Cleaves (Earth-Life Science Institute, Japan)
"The Prebiotic Small Molecule Inventory"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Jennifer Heemstra (Emory University, USA) and Martha Grover (Georgia Institute of Technology, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Compartmentalized and Catalytic Chemical Networks
Discussion Leader: Kepa Ruiz-Mirazo (University of the Basque Country, Spain)
7:30 pm - 8:00 pm
Christine Keating (Pennsylvania State University, USA)
"Complex Coacervation of RNA/Peptide Systems"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Neal Devaraj (University of Calfornia, San Diego, USA)
"De Novo Vesicle Formation and Reproduction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Ivan Korendovych (Syracuse University, USA)
"Self-Assembled Peptide Catalysts"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Autocatalysis, Self-Replication and Replication Networks
Discussion Leader: Ignacio Alfonso (Institute of Advanced Chemistry of Catalonia, CSIC, Spain)
9:00 am - 9:30 am
Kenso Soai (Tokyo University of Science, Japan)
"Autocatalysis and the Origin of Homochirality"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Douglas Philp (Northwestern University, USA)
"In Through the Out Door: Creating Instructable and Dynamic Reaction Networks Using Synthetic Replicators"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Nathaniel Wagner (Ben-Gurion University of the Negev, Israel)
"Using Replication Networks to Model Systems Complexification and Evolutionary Dynamics"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
Niles Lehman (Portland State University, USA)
"Scrambling to Make the RNA World"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Martha Grover (Georgia Institute of Technology, USA)
"Prediction and Emergence: The Power of Simulation for Complex Systems Analysis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Doron Lancet (Weizmann Institute of Science, Israel)
"Systems Protobiology: Could Compositional Lipid Catalytic Networks Be the First Replicators?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acid Systems Chemistry
Discussion Leader: Jennifer Heemstra (Emory University, USA)
7:30 pm - 8:00 pm
Rebecca Schulman (Johns Hopkins University, USA)
"How Can We Build a Biochemical 'Operating System'?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Andrew Ellington (University of Texas at Austin, USA)
"Novel Systems Based on the Programmability of Nucleic acid Conformers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Rong Ni (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Peptide/DNA Co-Assembled Virus Biomimetics"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Constantin Giurgiu (Harvard University, USA)
"The Regioselectivity of Chemical RNA Copying"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamic Functional Materials
Discussion Leader: Bing Xu (Brandeis University, USA)
9:00 am - 9:30 am
Ivan Aprahamian (Dartmouth College, USA)
"Structurally Simple Adaptive Functional Materials"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Raymond Astumian (University of Maine, USA)
"Adaptation Away from Equilibrium: Kinetics and Thermodynamics of Catalysis Driven Steady-States"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Ignacio Alfonso (Institute of Advanced Chemistry of Catalonia, CSIC, Spain)
"Dynamic Pseudopeptidic Disulfides: From Complexity to Applications"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Group Photo / Coffee Break
11:10 am - 11:40 am
Rein Ulijn (City University of New York, USA)
"Active and Reactive Peptide Ensembles"
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Christoph Flamm (University of Vienna, Austria)
"Computational Systems Chemistry"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Energy Dissipation in Dynamic Systems
Discussion Leader: Jay Goodwin (Emory University / MacArthur Foundation, USA)
5:30 pm - 6:00 pm
Rafal Klajn (Weizmann Institute of Science, Israel)
"Constructing Chemical Reaction Networks with Nanoparticulate Building Blocks"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:40 pm
Leonard Prins (University of Padova, Italy)
"Energy Dissipation in Chemical-Fuel Driven Self-Assembly"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Thomas Hermans (University of Strasbourg, France)
"Emergent Properties in Chemically Fueled Supramolecular Polymers"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Jerzy Maselko (University of Alaska Anchorage, USA)
"Controlling Growth of Architectures and Behaviors of Complex Chemical Organisms"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chemical Reactivity Far from Equilibrium
Discussion Leader: Agota Toth (University of Szeged, Hungary)
9:00 am - 9:30 am
Irving Epstein (Brandeis University, USA)
"Nonlinear, Dynamic Behavior in Time and Space"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Annette Taylor (University of Sheffield, United Kingdom)
"Catalytic Reaction Networks Coupled with Mass Transport"
10:10 am - 10:20 am
Discussion
10:20 am - 10:35 am
Pavan Bosukonda (University of Bristol, United Kingdom)
"Enzyme-Powered Motility in Buoyant Organoclay/DNA Protocells"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
Ognjen Miljanic (University of Houston, USA)
"Reversibility: From Messy Mixtures to Ordered Materials"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Bing Xu (Brandeis University, USA)
"The Emergent Molecular Properties of Peptides"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Yifei Zhang (Columbia University, USA)
"Complex Reaction Dynamics and Hydrodynamics from a Two-Enzyme Reaction Network"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Future of Systems Chemistry
Discussion Leader: Gonen Ashkenasy (Ben-Gurion University of the Negev, Israel)
7:30 pm - 7:45 pm
Olga Taran (Emory University, USA)
"Systems Chemistry of Plant-Bacteria Signaling in the Rhizosphere"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Peter Strazewski (University of Lyon, France)
"Population Growth and Encoding Principles in Self-Evolving Chemical Systems"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Jan van Esch (Technical Unversity of Delft, The Netherlands)
"Far-from-Equilibrium Phenomena in Molecular Systems"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Sijbren Otto (University of Groningen, The Netherlands)
"Towards De Novo Life: From Self-Replication to Energy Dissipation and a Proto-Metabolism"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure