| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: A Sulfur-Centered World:
From Primordial Chemistry
to Human Biology |
| Discussion Leaders: Tobias Dick (German Cancer Research Center, Germany) and Vadim Gladyshev (Harvard Medical School, USA) |
| 7:40 pm - 8:20 pm | Ruma Banerjee (University of Michigan, USA)
"Signaling Through Sulfide: Chemical Biology of Sulfide
Homeostasis" |
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Michel Toledano (French Alternative Energies and Atomic Energy Commission (CEA), France)
"The Control of Eukaryotic Protein Secretion by a Novel Pathway Regulating Glutathione Traffic in and out of the ER" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Emerging
Chemical, Omics and Computational Tools for Redox Biologists |
| Discussion Leaders: Vsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia) and Leslie Poole (Wake Forest School of Medicine, USA) |
| 9:00 am - 9:20 am | Dean Jones (Emory University, USA)
"Exposure Memory and the Redox Theory of Aging" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Harry Ischiropoulos (University of Pennsylvania, USA)
"Potential Functional Roles for Redox Regulated Cysteine Residues" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Melissa Kemp (Georgia Institute of Technology, USA)
"Computational Strategies for Interrogating Thiol Regulated Systems" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Eranthie Weerapana (Boston College, USA)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Milos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
"Thioredoxin Controls Intracellular Levels of Protein Persulfidation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Troy Langford (Massachusetts Institute of Technology, USA)
"Using Kinetic Models and Engineered Proteins to Further Quantitative Understanding of Thiol-Based Redox Regulation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Melissa Kemp (Georgia Institute of Technology, USA) and Kate Carroll (The Scripps Research Institute, USA) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Essential
Function of H2S and Other S-Containing Biomolecules in Human Health and Biology |
| Discussion Leaders: Ming Xian (Washington State University, USA) and Rodney Levine (National Institutes of Health, USA) |
| 7:30 pm - 7:50 pm | Alban Longchamp (Harvard University, USA)
"Regulation of Endogenous H2S and Mechanisms of Action in Angiogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ed Schmidt (Montana State University, USA)
"The Robustness of Mammalian Redox Homeostasis: NADPH-Dependent and -Independent Disulfide Reductase Systems" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Michael Pluth (University of Oregon, USA)
"Synthetic H2S Donors with Defined Release Mechanisms and Tunable Release Rates" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Bruno Manta (Brigham and Women's Hospital / Harvard Medical School, USA)
"Reversible Methionine Oxidation by Mical/MsrB as a New Axis in Redox Regulation and Signaling" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Weijun Qian (Pacific Northwest National Laboratory, USA)
"Stoichiometric Quantification of S-Glutathionylation and Total Thiol Oxidation and Potential Crosstalk with Protein Phosphorylation" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Jen-Tsan Chi (Duke University, USA)
"Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Exploiting
Redox Effects in Modern Therapeutics |
| Discussion Leaders: Kate Carroll (The Scripps Research Institute, USA) and Arne Holmgren (Karolinska Institutet, Sweden) |
| 9:00 am - 9:20 am | David Boothman (University of Texas Southwestern Medical School, USA)
"Exploiting NQO1 Bioactivatable Drugs for Tumor-Selective DNA Repair Inhibition" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Brion Murray (Pfizer Oncology Research Unit, USA)
"Protein S-Glutathionylation: An Emerging Post-translational Modification that Impacts Cell Biology and the Disease State" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Daret St. Clair (University of Kentucky, USA)
"A Redox Distinction Approach to Cancer Therapy" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Martin Bergo (Karolinska Institute, Sweden)
"On the Role of Antioxidants in Tumor Initiation and Progression" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Yvonne Janssen-Heininger (University of Vermont, USA)
"Targeting S-Glutathionylation Chemistry to Combat Tissue Fibrosis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Jade Mims (Wake Forest School of Medicine, USA)
"Integration of Redox-Regulated Signaling and Metabolism in Head and Neck Cancer" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Redox
Regulation of Cellular Communication |
| Discussion Leaders: Thomas Michel (Brigham and Women's Hospital / Harvard Medical School, USA) and Sue Goo Rhee (Yonsei University College of Medicine, South Korea) |
| 7:30 pm - 7:50 pm | Agnieszka Chacinska (International Institute of Molecular and Cell Biology in Warsaw, Poland)
"Cellular Consequences of Mitochondrial Stress" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Michael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland)
"Mitochondria, Metabolism and Aging" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Patricia Zambryski (University of California, Berkeley, USA)
"Plant Cell-to-Cell Communication via Plasmodesmata: Regulation by Organelle Redox State" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Stefano Bestetti (Fondazione Centro San Raffaele, Italy)
"Regulation of H2O2 Transport in Tumor Growth and Progression" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Prakash Palde (The Scripps Research Institute, USA)
"Thioredoxin Selectively Recognizes Oxidized Target Proteins via an Entropy-Driven Common Mechanism" |
| 9:25 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Case
Studies in Redox Control of Cellular Processes |
| Discussion Leaders: Elena Hidalgo (Pompeu Fabra University, Spain) and Tobias Dansen (University Medical Center Utrecht, The Netherlands) |
| 9:00 am - 9:20 am | Jose Antonio Barcena (University of Cordoba, Spain)
"Redox Control of Protein Thiols by Redoxins Under Nitric Oxide Signaling" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Myra Conway (University of the West of England, United Kingdom)
"Dysregulated Redox Metabolons and Their Implications in Alzheimer's Disease" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Ana Denicola (University of the Republic, Uruguay)
"Interplay Between Nitration and Overoxidation in Peroxiredoxins. Impact on H2O2 Detoxification and Signaling" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Malcolm Jackson (University of Liverpool, United Kingdom)
"Redox Signaling of Adaptive Responses to Contractile Activity in Skeletal Muscle" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Carola Neumann (Magee-Womens Research Institute, USA)
"PRDX1 in Redox Regulation of Cancer Signaling" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Sarah Stöcker (German Cancer Research Center (DKFZ), Germany)
"Thiol Peroxidase Based Redox Relays" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signaling
Mediated by Reactive Oxygen, Nitrogen and Sulfur Species |
| Discussion Leaders: Christine Winterbourn (University of Otago, Christchurch, New Zealand) and Trent Tipple (University of Alabama at Birmingham, USA) |
| 7:30 pm - 7:50 pm | Elizabeth Veal (Newcastle University, United Kingdom)
"Role of Peroxiredoxins in Redox Signaling, Stress Responses and Ageing" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Cysteinyl-tRNA Synthetase Controls Protein Polysulfidation and Mitochondrial Functions" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Massimo Santoro (VIB Vesalius Research Center, KU Leuven, Belgium)
"Redox Signaling and Metabolism in Angiogenesis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Gary Loake (University of Edinburgh, United Kingdom)
"A Central Role for S-Nitrosylation in Plant Immunity" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Redox Research
at the Interface of Environment, Aging and Cancer |
| Discussion Leaders: Ursula Jakob (University of Michigan, USA) and W. Todd Lowther (Wake Forest School of Medicine, USA) |
| 9:00 am - 9:20 am | Anna Rubartelli (IRCCS AOU San Martino IST, Italy)
"Targeting Cellular Stress Responses to Prevent Tumor Onset and Progression: Redox-Related
Mechanisms and Preclinical Studies" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Mary Helen Barcellos-Hoff (University of California, San Francisco, USA)
"Redox Regulation of TGFβ and Its Implications in Cancer Biology" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | John Mieyal (Case Western Reserve University, USA)
"The Yin and Yang of Glutaredoxin Homeostasis in Brain Cells: Implications for Parkinson's Disease" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | David Gius (Feinberg School of Medicine, Northwestern University, USA)
"SIRT3 Is a Mitochondrial Fidelity Protein Directing
the Metabolic Stress Response" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Beatriz Alvarez (University of the Republic, Uruguay)
"Reaction of Thiols with Conjugated Nitrolinoleic Acid" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Jesalyn Bolduc (Wake Forest School of Medicine, USA)
"Unlocking the Mystery of Variable Hyperoxidation Sensitivity in Peroxiredoxins: Two Novel, Key Motifs" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:30 pm | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Thiols
and Antioxidant Defense in Bacteria, Plants and Beyond |
| Discussion Leaders: Luise Krauth-Siegel (Heidelberg University, Germany) and Andreas Meyer (University of Bonn, Germany) |
| 7:30 pm - 7:50 pm | Joris Messens (VIB, Vrije Universiteit Brussel, Belgium)
"Promiscuity in Thiol Redox Control" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Frederic Barras (CNRS, France)
"How to Keep Fe-S Clusters Delivery Efficient Under Iron Limitation (and Other Difficulties)?" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Gloria Muday (Wake Forest University, USA)
"The Role of Flavonols as Antioxidants Protecting Pollen from High Temperature-Induced ROS" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Limei Zhang (University of Nebraska-Lincoln, USA)
"The WhiB Proteins in Stress Response in Mycobacterium tuberculosis" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Edward Chouchani (Dana-Farber Cancer Institute, USA)
"Mitochondrial ROS Regulate Thermogenic Energy Expenditure and Sulfenylation of UCP1" |
| 9:25 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
